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Biology and Biochemistry

D-Index
73
Citations
17801
World Ranking
5975
National Ranking
428

Overview

Philipp A. Lang is affiliated with Heinrich Heine University Düsseldorf in Germany and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research addresses various subfields including Immunology, Infectious Diseases, Molecular Biology, Epidemiology, and Oncology.

The scientist's work covers several principal topics, notably:

  • Immune Cell Function and Interaction
  • Interferon and Immune Responses
  • Immunotherapy and Immune Responses
  • SARS-CoV-2 and COVID-19 Research
  • Immune Response and Inflammation
  • T-cell and B-cell Immunology
  • Cytokine Signaling Pathways and Interactions

Philipp A. Lang has collaborated frequently with several co-authors, including:

  • Karl S. Lang
  • Haifeng C. Xu
  • Aleksandra A. Pandyra
  • Paweł Stachura
  • Dieter Häussinger

Their publishing record includes multiple articles in recognized journals such as Cell Reports, bioRxiv (Cold Spring Harbor Laboratory), Pathogens, Cell Reports Medicine, and Nature Communications. They have multiple publications in Cell Reports and bioRxiv, and at least two each in Cell Reports Medicine and Nature Communications.

Selected recent papers include:

  • "Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells," 2020, Cell Reports Medicine
  • "Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications," 2020, Journal of Experimental & Clinical Cancer Research
  • "Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease," 2020, Nature Communications
  • "Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection," 2020, Cell Reports
  • "Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells," 2022, Nature Communications

This body of work reflects an ongoing focus on immune cell mechanisms and viral infections, with a particular emphasis on understanding immune responses and developing therapeutic approaches related to infections and cancer.

Best Publications

  • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

    Tobias Junt;E. Ashley Moseman;Matteo Iannacone;Steffen Massberg

  • The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

    Tuoqi Wu;Yun Ji;E. Ashley Moseman;Haifeng C. Xu

  • Mechanisms of suicidal erythrocyte death.

    Karl S Lang;Philipp A Lang;Christian Bauer;Christophe Duranton

  • Glutathione Primes T Cell Metabolism for Inflammation

    Tak W. Mak;Tak W. Mak;Melanie Grusdat;Gordon S. Duncan;Catherine Dostert

  • Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.

    Philipp A Lang;Marcus Schenck;Jan P Nicolay;Jan Ulrich Becker

  • Role of Ca2+-activated K+ channels in human erythrocyte apoptosis

    Philipp A. Lang;Stefanie Kaiser;Swetlana Myssina;Thomas Wieder

  • IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

    Marc Pellegrini;Thomas Calzascia;Jesse G. Toe;Simon P. Preston

  • iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

    David R. McIlwain;Philipp A. Lang;Philipp A. Lang;Thorsten Maretzky;Koichi Hamada

  • Ion channels in cell proliferation and apoptotic cell death.

    F Lang;M Föller;K S Lang;P A Lang

  • Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

    Philipp A. Lang;Karl S. Lang;Haifeng C. Xu;Melanie Grusdat

  • Suicidal erythrocyte death in sepsis

    Daniela S. Kempe;Ahmad Akel;Philipp A. Lang;Tobias Hermle

  • Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes

    K S Lang;S Myssina;V Brand;C Sandu

  • Ceramide in suicidal death of erythrocytes.

    Florian Lang;Erich Gulbins;Philipp A Lang;Donatella Zappulla

  • Mechanisms and Significance of Eryptosis

    Florian Lang;Karl S. Lang;Philipp A. Lang;Stephan M. Huber

  • Protein kinase C mediates erythrocyte "programmed cell death" following glucose depletion.

    Barbara A. Klarl;Philipp A. Lang;Daniela S. Kempe;Olivier M. Niemoeller

  • NK cells regulating T cell responses: mechanisms and outcome.

    Josh Crouse;Haifeng C. Xu;Philipp A. Lang;Annette Oxenius

  • Aggravation of viral hepatitis by platelet-derived serotonin

    Philipp A. Lang;Claudio Contaldo;Panco Georgiev;Ashraf Mohammad El-Badry

  • Enhanced programmed cell death of iron-deficient erythrocytes.

    Daniela S. Kempe;Philipp A. Lang;Christophe Duranton;Ahmad Akel

  • Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome.

    Philipp A. Lang;Ortraud Beringer;Jan P. Nicolay;Oliver Amon

  • Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus.

    Nadine Honke;Namir Shaabani;Giuseppe Cadeddu;Ursula R Sorg

Frequent Co-Authors

Karl S. Lang
Karl S. Lang University of Duisburg-Essen
Florian Lang
Florian Lang University of Tübingen
Dieter Häussinger
Dieter Häussinger Heinrich Heine University Düsseldorf
Thomas Wieder
Thomas Wieder University of Tübingen
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Stephan M. Huber
Stephan M. Huber University of Tübingen
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Erich Gulbins
Erich Gulbins University of Duisburg-Essen
Max Löhning
Max Löhning Charité - University Medicine Berlin
Jürgen Scheller
Jürgen Scheller Heinrich Heine University Düsseldorf

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