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D-Index & Metrics

Immunology

D-Index
59
Citations
15686
World Ranking
3398
National Ranking
1575

Overview

Facundo D. Batista is affiliated with Harvard Medical School in the United States. Their research primarily focuses on immunology and microbiology, with a strong emphasis on the study of immune cell function and interaction, T-cell and B-cell immunology, and HIV research and treatment. Their work also encompasses immunotherapy and immune responses, monoclonal and polyclonal antibodies research, vaccines and immunoinformatics approaches, as well as CRISPR and genetic engineering techniques.

The scientist has authored multiple papers published in prominent scientific venues. Some of the recent publications include:

  • Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses, 2022, Immunity
  • Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice, 2022, Immunity
  • mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies, 2024, Science
  • Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors, 2020, The EMBO Journal
  • Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies, 2021, Immunity

Frequent co-authors contributing alongside Facundo D. Batista include Usha Nair, William R. Schief, John E. Warner, Sven Kratochvil, and Kathrin H. Kirsch. These collaborators reflect a network engaged in advancing various immunology and molecular biology topics.

The scientist's research is regularly published in key venues such as bioRxiv (Cold Spring Harbor Laboratory), Immunity, The EMBO Journal, Nature Immunology, and Science Immunology.

Facundo D. Batista's work spans several subfields including immunology, molecular biology, virology, radiology, nuclear medicine and imaging, and public health, environmental and occupational health. Their contributions involve fundamental aspects of immune cell mechanisms as well as applied genetic engineering methods like CRISPR to enhance preclinical models.

Best Publications

  • The who, how and where of antigen presentation to B cells.

    Facundo D Batista;Naomi E Harwood

  • B cells acquire antigen from target cells after synapse formation.

    Facundo D. Batista;Dagmar Iber;Michael S. Neuberger

  • B Cells Acquire Particulate Antigen in a Macrophage-Rich Area at the Boundary between the Follicle and the Subcapsular Sinus of the Lymph Node

    Yolanda R. Carrasco;Facundo D. Batista

  • Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate

    Facundo D Batista;Michael S Neuberger

  • B cell ligand discrimination through a spreading and contraction response.

    S. J. Fleire;J. P. Goldman;J. P. Goldman;Y. R. Carrasco;M. Weber

  • Early Events in B Cell Activation

    Naomi E Harwood;Facundo D Batista

  • F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

    Susan Ahrens;Santiago Zelenay;David Sancho;Pavel Hanč

  • CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.

    David Depoil;Sebastian Fleire;Bebhinn L Treanor;Michele Weber

  • LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation.

    Yolanda R Carrasco;Sebastian J Fleire;Thomas Cameron;Michael L Dustin

  • The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

    Bebhinn Treanor;David Depoil;Aitor Gonzalez-Granja;Patricia Barral

  • The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.

    Pieta K. Mattila;Christoph Feest;David Depoil;Bebhinn Treanor

  • Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.

    Theresa L. O'Keefe;Gareth T. Williams;Facundo D. Batista;Michael S. Neuberger

  • Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

    Pheh-Ping Chang;Patricia Barral;Jessica Fitch;Alvin Pratama

  • Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

    Katrina L Randall;Katrina L Randall;Teresa Lambe;Andy L Johnson;Andy L Johnson;Bebhinn Treanor

  • A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

    Jon M. Steichen;Ying-Cing Lin;Colin Havenar-Daughton;Colin Havenar-Daughton;Simone Pecetta

  • The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

    C McCarthy;D Shepherd;S Fleire;V S Stronge

  • B cells extract and present immobilized antigen: implications for affinity discrimination.

    Facundo D. Batista;Michael S. Neuberger

  • CD169+ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

    Patricia Barral;Paolo Polzella;Andreas Bruckbauer;Nico van Rooijen

  • A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes

    Andrew Smith;Yolanda R. Carrasco;Paula Stanley;Nelly Kieffer

  • B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo

    P Barral;J Eckl-Dorna;NE Harwood;C De Santo

  • Clonal B‐cell expansions in peripheral blood of HCV‐infected patients

    F. Franzin;D. G. Efremov;G. Pozzato;P. Tulissi

Frequent Co-Authors

Vincenzo Cerundolo
Vincenzo Cerundolo University of Oxford
Michael S. Neuberger
Michael S. Neuberger MRC Laboratory of Molecular Biology
Henning Urlaub
Henning Urlaub University of Göttingen
Jürgen Wienands
Jürgen Wienands University of Göttingen
Shane Crotty
Shane Crotty La Jolla Institute For Allergy & Immunology
Tony Pawson
Tony Pawson University of Toronto
Michael Way
Michael Way The Francis Crick Institute
Guillaume Charras
Guillaume Charras London Centre for Nanotechnology
Julian E. Sale
Julian E. Sale MRC Laboratory of Molecular Biology

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