World's Best Scientists 2026 revealed!

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Immunology

D-Index
110
Citations
53363
World Ranking
492
National Ranking
14

Medicine

D-Index
110
Citations
53472
World Ranking
5478
National Ranking
149

Research.com Recognitions

  • 2013 - Member of the National Academy of Sciences
  • 2009 - Fellow of the Royal Society, United Kingdom
  • 2001 - Gottschalk Medal, Australian Academy of Science
  • 1998 - AAI-BD Biosciences Investigator Award, American Association of Immunologists

Overview

Christopher C. Goodnow is affiliated with the Garvan Institute of Medical Research in Australia. Their research spans primarily the fields of immunology and microbiology, as well as medicine. Within these broad fields, key subfields of study include immunology, genetics, infectious diseases, molecular biology, and oncology.

Their work focuses on several main research topics, including:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunodeficiency and Autoimmune Disorders
  • Chronic Lymphocytic Leukemia Research
  • Monoclonal and Polyclonal Antibodies Research
  • SARS-CoV-2 and COVID-19 Research
  • CAR-T Cell Therapy Research

Frequently, Christopher C. Goodnow publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Proceedings of the National Academy of Sciences
  • Immunity
  • Immunology and Cell Biology

Their recent scientific papers include:

  • "NINJ1 mediates plasma membrane rupture during lytic cell death," published in 2021 in Nature
  • "Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody," published in 2020 in Cell
  • "Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate," published in 2021 in Nucleic Acids Research
  • "Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells," published in 2022 in Science Immunology
  • "STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation," published in 2022 in Immunity

Collaborations are an important aspect of their research. Frequent coauthors include Katherine Jackson, Timothy J. Peters, Etienne Masle-Farquhar, Robert Brink, and Joanne H. Reed.

Christopher C. Goodnow has been recognized with several awards, including:

  • Member of the National Academy of Sciences (2013)
  • Fellow of the Royal Society, United Kingdom (2009)
  • Gottschalk Medal, Australian Academy of Science (2001)
  • AAI-BD Biosciences Investigator Award, American Association of Immunologists (1998)

Best Publications

  • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  • Differential activation of transcription factors induced by Ca2+ response amplitude and duration

    Ricardo E. Dolmetsch;Richard S. Lewis;Christopher C. Goodnow;James I. Healy

  • Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

    Christopher C Goodnow;Jeffrey Crosbie;Stephen Adelstein;Thomas B Lavoie

  • C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

    Paul W. Dempsey;Michael E. D. Allison;Srinivas Akkaraju;Christopher C. Goodnow

  • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

    Carola G. Vinuesa;Matthew C. Cook;Constanza Angelucci;Vicki Athanasopoulos

  • Aire regulates negative selection of organ-specific T cells

    Adrian Liston;Sylvie Lesage;Judith Wilson;Leena Peltonen

  • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens.

    Suzanne B. Hartley;Jeffrey Crosbie;Robert Brink;Aaron B. Kantor

  • Cellular and genetic mechanisms of self tolerance and autoimmunity

    Christopher C. Goodnow;Jonathon Sprent;Barbara Fazekas de St Groth;Carola G. Vinuesa

  • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

    Chad K Heazlewood;Matthew C Cook;Rajaraman Eri;Gareth R Price

  • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

    Nicholas Simpson;Paul A. Gatenby;Anastasia Wilson;Shreya Malik

  • NINJ1 mediates plasma membrane rupture during lytic cell death

    Nobuhiko Kayagaki;Opher S. Kornfeld;Bettina L. Lee;Irma B. Stowe

  • Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

    Jason G. Cyster;Suzanne B. Hartley;Christopher C. Goodnow

  • Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

    Suzanne B. Hartley;Michael P. Cooke;David A. Fulcher;Alan W. Harris

  • Two levels of protection for the B cell genome during somatic hypermutation

    Man Liu;Jamie L. Duke;Daniel J. Richter;Daniel J. Richter;Carola G. Vinuesa

  • Induction of self-tolerance in mature peripheral B lymphocytes

    Christopher C. Goodnow;Jeffrey Crosbie;Helle Jorgensen;Robert A. Brink

  • DNA repair is limiting for haematopoietic stem cells during ageing

    Anastasia Nijnik;Lisa Woodbine;Caterina Marchetti;Caterina Marchetti;Sara Dawson

  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4 + T cells

    Jeffrey C. Rathmell;Michael P. Cooke;William Y. Ho;Jeff Grein

  • Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

    Jason G. Cyster;Christopher C. Goodnow

  • Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

    Christopher C. Goodnow

  • Multistep Pathogenesis of Autoimmune Disease

    Christopher C. Goodnow

  • Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells

    Daniel Herbert Donald Gray;Natalie Louise Seach;Tomoo Ueno;Morag Kertanya Milton

  • Transgenic mice and analysis of B-cell tolerance.

    C C Goodnow

  • erratum: Differential activation of transcription factors induced by Ca2+ response amplitude and duration

    Unknown

Frequent Co-Authors

Robert Brink
Robert Brink University of New South Wales
Carola G. Vinuesa
Carola G. Vinuesa Australian National University
Richard J. Cornall
Richard J. Cornall University of Oxford
Matthew C. Cook
Matthew C. Cook Australian National University
Jason G. Cyster
Jason G. Cyster University of California, San Francisco
Adrian Liston
Adrian Liston University of Cambridge
Stuart G. Tangye
Stuart G. Tangye Garvan Institute of Medical Research
Antony Basten
Antony Basten Garvan Institute of Medical Research
Teresa Lambe
Teresa Lambe University of Oxford
Moira K O'Bryan
Moira K O'Bryan University of Melbourne

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