World's Best Scientists 2026 revealed!
Christophe Benoist

Christophe Benoist

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Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
161
Citations
95779
World Ranking
78
National Ranking
52

Medicine

D-Index
162
Citations
96529
World Ranking
718
National Ranking
407

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2005 - Member of the National Academy of Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Christophe Benoist is affiliated with Harvard University in the United States. Their research primarily spans the fields of immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. Within these broad disciplines, their work focuses specifically on immunology, molecular biology, infectious diseases, oncology, and astronomy and astrophysics.

The scientist's work covers a range of topics in immunology and related areas. Key themes include immune cell function and interaction, T-cell and B-cell immunology, single-cell and spatial transcriptomics, IL-33, ST2, and ILC pathways, SARS-CoV-2 and COVID-19 research, gut microbiota and health, and CAR-T cell therapy research.

Christophe Benoist has an extensive publication record in various high-profile scientific venues. Frequently publishing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature Immunology
  • Immunity
  • Science Immunology

Their recent influential papers include:

  • "The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments," 2021, Nature Communications
  • "Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells," 2022, Cell
  • "Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes," 2021, Nature Immunology
  • "An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint," 2020, Cell
  • "Profound Treg perturbations correlate with COVID-19 severity," 2021, Proceedings of the National Academy of Sciences

Frequent collaborators include Diane Mathis, Kaitavjeet Chowdhary, Deepshika Ramanan, Juliette Léon, and Ricardo N. Ramírez. Collaborations with these researchers have contributed to many publications and advances in immunological research.

Christophe Benoist has been recognized by election to prestigious scientific organizations. They are a member of the National Academy of Sciences since 2005 and a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

    Mark S. Anderson;Emily S. Venanzi;Ludger Klein;Zhibin Chen

  • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

    Markus Feuerer;Laura Herrero;Laura Herrero;Daniela Cipolletta;Afia Naaz

  • The Immunological Genome Project: networks of gene expression in immune cells

    Tracy S P Heng;Michio W Painter;Kutlu Elpek;Veronika Lukacs-Kornek

  • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells

    Hsin Jung Wu;Ivaylo I. Ivanov;Jaime Darce;Jaime Darce;Kimie Hattori;Kimie Hattori

  • In vivo sequence requirements of the SV40 early promoter region

    Christophe Benoist;Christophe Benoist;Pierre Chambon

  • The Human Cell Atlas

    Aviv Regev;Aviv Regev;Aviv Regev;Sarah A Teichmann;Sarah A Teichmann;Sarah A Teichmann;Eric S Lander;Eric S Lander;Eric S Lander;Ido Amit

  • FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

    Yongqing Wu;Madhuri Borde;Vigo Heissmeyer;Markus Feuerer

  • Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

    R Breathnach;C Benoist;K O'Hare;F Gannon

  • Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

    Hachung Chung;Hachung Chung;Sünje Johanna Pamp;Sünje Johanna Pamp;Jonathan A. Hill;Neeraj K. Surana;Neeraj K. Surana;Neeraj K. Surana

  • β-Cell death during progression to diabetes

    Diane Mathis;Luis Vence;Christophe Benoist

  • A Special Population of Regulatory T Cells Potentiates Muscle Repair

    Dalia Burzyn;Wilson Kuswanto;Dmitriy Kolodin;Jennifer L. Shadrach;Jennifer L. Shadrach

  • PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue T reg cells

    Daniela Cipolletta;Markus Feuerer;Markus Feuerer;Amy Li;Nozomu Kamei;Nozomu Kamei

  • The ovalbumin gene - sequence of putative control regions

    C. Benoist;K. O'Hare;R. Breathnach;Pierre Chambon

  • Organ-Specific Disease Provoked by Systemic Autoimmunity

    Valérie Kouskoff;Anne-Sophie Korganow;Véronique Duchatelle;Claude Degott

  • Mice lacking MHC class II molecules

    Dominic Cosgrove;David Gray;Andrée Dierich;Jim Kaufman

  • The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

    Sokol Haxhinasto;Diane Mathis;Diane Mathis;Christophe Benoist;Christophe Benoist

  • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

    Nicole Joller;Ester Lozano;Patrick R. Burkett;Bonny Patel

  • From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins

    Anne-Sophie Korganow;Hong Ji;Sara Mangialaio;Véronique Duchatelle

  • A multiplicity of CCAAT box-binding proteins

    Arnulf Dorn;Jacques Bollekens;Adrian Staub;Christophe Benoist

  • Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

    David M. Lee;Daniel S. Friend;Michael F. Gurish;Christophe Benoist

Frequent Co-Authors

Diane Mathis
Diane Mathis Harvard University
Aviv Regev
Aviv Regev Genentech
Philip L. De Jager
Philip L. De Jager Columbia University
Ralph Weissleder
Ralph Weissleder Harvard University
Nir Hacohen
Nir Hacohen Harvard University
Towfique Raj
Towfique Raj Icahn School of Medicine at Mount Sinai
Amy J. Wagers
Amy J. Wagers Harvard University
L. N. da Costa
L. N. da Costa Harvard University
Daphne Koller
Daphne Koller insitro Inc.
Antonio Gonzalez
Antonio Gonzalez University of Santiago de Compostela

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