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Genetics

D-Index
54
Citations
21757
World Ranking
3616
National Ranking
1567

Overview

Towfique Raj is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research predominantly focuses on the intersections of biochemistry, genetics, and molecular biology, with significant contributions in medicine. Their work encompasses several subfields including molecular biology, neurology, genetics, physiology, and psychiatry and mental health.

The scientist's main topics of research include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Amyotrophic Lateral Sclerosis Research
  • Bioinformatics and Genomic Networks
  • RNA Research and Splicing
  • RNA regulation and disease

Towfique Raj has authored numerous papers, with recent notable publications including:

  • "TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A," 2022, published in Nature
  • "Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies," 2022, published in Nature Genetics
  • "Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia," 2020, published in Journal of Clinical Investigation
  • "Genetics of the human microglia regulome refines Alzheimer's disease risk loci," 2022, published in Nature Genetics
  • "Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes," 2022, published in Nature Neuroscience

The scientist frequently collaborates with several co-authors, including Jack Humphrey, John F. Crary, Kátia de Paiva Lopes, Ricardo A. Vialle, and Alison Goate.

Their research output is commonly found in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Alzheimer's & Dementia, Acta Neuropathologica, and Nature Communications.

Best Publications

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Niamh Mullins;Andreas J. Forstner;Andreas J. Forstner;Andreas J. Forstner;Kevin S. O'Connell;Kevin S. O'Connell;Brandon Coombes

  • Gene expression elucidates functional impact of polygenic risk for schizophrenia

    Menachem Fromer;Panos Roussos;Solveig K. Sieberts;Jessica S. Johnson

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

    Philip Lawrence De Jager;Gyan Srivastava;Katie Lunnon;Jeremy Burgess

  • Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics

    Barbara Elaine Stranger;Eli A. Stahl;Towfique Raj

  • The transcriptional landscape of age in human peripheral blood

    Marjolein J. Peters;Roby Joehanes;Luke C. Pilling;Claudia Schurmann;Claudia Schurmann

  • CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

    Elizabeth M Bradshaw;Lori B Chibnik;Brendan T Keenan;Brendan T Keenan;Linda Ottoboni

  • Patterns of \(Cis\) Regulatory Variation in Diverse Human Populations

    Barbara Elaine Stranger;Stephen B. Montgomery;Stephen B. Montgomery;Antigone S. Dimas;Leopold Parts

  • Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.

    Towfique Raj;Katie Rothamel;Sara Mostafavi;Chun Ye

  • Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans

    Christiane Reitz;Gyungah Jun;Adam Naj;Ruchita Rajbhandary

  • Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

    Mark N. Lee;Mark N. Lee;Chun Ye;Alexandra Chloé Villani;Alexandra Chloé Villani;Towfique Raj;Towfique Raj;Towfique Raj

  • Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

    Towfique Raj;Yang I. Li;Garrett Wong;Jack Humphrey

  • A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

    Kuan Lin Huang;Edoardo Marcora;Anna A. Pimenova;Antonio F. Di Narzo

  • Parsing the Interferon Transcriptional Network and Its Disease Associations

    Sara Mostafavi;Sara Mostafavi;Hideyuki Yoshida;Devapregasan Moodley;Hugo LeBoité

  • Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

    Nikolaos A. Patsopoulos;Nikolaos A. Patsopoulos;Lisa F. Barcellos;Lisa F. Barcellos;Rogier Q. Hintzen;Catherine Schaefer

  • A combined linkage-physical map of the human genome.

    X. Kong;K. Murphy;T. Raj;C. He

  • Intersection of population variation and autoimmunity genetics in human T cell activation

    Chun Jimmie Ye;Ting Feng;Ho Keun Kwon;Towfique Raj;Towfique Raj

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

    Gyan Srivastava;Katie Lunnon;Jeremy Burgess;Lei Yu

  • Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

    T. Raj;K. Rothamel;S. Mostafavi;C. Ye

  • Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

    M. N. Lee;C. Ye;A.-C. Villani;T. Raj

Frequent Co-Authors

Philip L. De Jager
Philip L. De Jager Columbia University
Barbara Elaine Stranger
Barbara Elaine Stranger Northwestern University
Lori B. Chibnik
Lori B. Chibnik Harvard University
David A. Bennett
David A. Bennett Rush University Medical Center
Denis A. Evans
Denis A. Evans Rush University Medical Center
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Nir Hacohen
Nir Hacohen Harvard University
Joshua M. Shulman
Joshua M. Shulman Baylor College of Medicine
Christophe Benoist
Christophe Benoist Harvard University
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital

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