World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
18226
World Ranking
9033
National Ranking
240

Overview

Robert Kleemann is affiliated with the Netherlands Organisation for Applied Scientific Research in the Netherlands. Their research primarily focuses on the field of Medicine, with particular emphasis on several subfields including Physiology, Epidemiology, Endocrinology, Diabetes and Metabolism, Cardiology and Cardiovascular Medicine, and Surgery.

The scientist's work covers a range of topics centered on metabolic and cardiovascular health, with significant academic contributions to areas such as:

  • Liver Disease Diagnosis and Treatment
  • Diet and metabolism studies
  • Adipose Tissue and Metabolism
  • Diet, Metabolism, and Disease
  • Nutrition and Health in Aging
  • Adipokines, Inflammation, and Metabolic Diseases
  • Lipid metabolism and disorders

They have published extensively in several scientific journals. The most frequent publication venues include:

  • Journal of Hepatology
  • The FASEB Journal
  • International Journal of Molecular Sciences
  • Zenodo (CERN European Organization for Nuclear Research)
  • GeroScience

The following recent papers showcase their research output along with the year and the journal of publication:

  • Neuroimmune cardiovascular interfaces control atherosclerosis (2022, Nature)
  • Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles (2022, Hepatology)
  • Sex differences in skeletal muscle-aging trajectory: same processes, but with a different ranking (2023, GeroScience)
  • Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr−/−.Leiden mice (2020, The FASEB Journal)
  • The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis (2022, PLoS ONE)

The scientist collaborates frequently with several co-authors, notable among them are:

  • Martine C. Morrison
  • Amanda J. Kiliaan
  • Lars Verschuren
  • Martien P. M. Caspers
  • Eveline Gart

Best Publications

  • Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD.

    Eveline Gart;Everton Souto Lima;Frank Schuren;Christa G. F. De Ruiter

  • MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

    Jürgen Bernhagen;Regina Krohn;Hongqi Lue;Julia L Gregory

  • Cytokines and atherosclerosis: a comprehensive review of studies in mice

    Robert Kleemann;Susanne Zadelaar;Teake Kooistra

  • Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1

    Robert Kleemann;Angelika Hausser;Georg Geiger;Ralf Mischke

  • Mouse Models for Atherosclerosis and Pharmaceutical Modifiers

    Susanne Zadelaar;Robert Kleemann;Lars Verschuren;Jitske de Vries-Van der Weij

  • Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

    Wen Liang;Aswin L. Menke;Ann Driessen;Ger H. Koek

  • Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease.

    Hongqi Lue;Robert Kleemann;Thierry Calandra;Thierry Roger

  • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.

    Robert Kleemann;Lars Verschuren;Martine Morrison;Susanne Zadelaar

  • Expression of Macrophage Migration Inhibitory Factor in Different Stages of Human Atherosclerosis

    Anke Burger-Kentischer;Heike Goebel;Rüdiger Seiler;Gustav Fraedrich

  • Disulfide analysis reveals a role for macrophage migration inhibitory factor (MIF) as thiol-protein oxidoreductase

    Robert Kleemann;Aphrodite Kapurniotu;Rainer W Frank;André Gessner

  • Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells.

    Jan H.N. Lindeman;Hazem Abdul-Hussien;J. Hajo van Bockel;Ron Wolterbeek

  • High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

    Roel A. van der Heijden;Fareeba Sheedfar;Martine C. Morrison;Pascal P. H. Hommelberg

  • Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

    Robert Kleemann;Lars Verschuren;Marjan J van Erk;Yuri Nikolsky

  • Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation

    Robert Kleemann;Philippe P. Gervois;Philippe P. Gervois;Lars Verschuren;Lars Verschuren;Bart Staels;Bart Staels

  • Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate

    Philippe Gervois;Robert Kleemann;Antoine Pilon;Frédéric Percevault

  • The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate Treatment

    Stéphane Mandard;Fokko Zandbergen;Nguan Soon Tan;Pascal Escher

  • Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro

    Robert Kleemann;Lars Verschuren;Bert-Jan de Rooij;Jan Lindeman

  • Collagen Degradation in the Abdominal Aneurysm : A Conspiracy of Matrix Metalloproteinase and Cysteine Collagenases

    Hazem Abdul-Hussien;Ratna G.V. Soekhoe;Ekkehard Weber;Jan H. von der Thüsen

  • Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin

    Robert Kleemann;Hans M.G. Princen;Jef J. Emeis;J. Wouter Jukema

  • Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro.

    K Bellmann;A Wenz;J Radons;V Burkart

Frequent Co-Authors

Ben van Ommen
Ben van Ommen Netherlands Organisation for Applied Scientific Research
Jürgen Bernhagen
Jürgen Bernhagen Ludwig-Maximilians-Universität München
Peter Heeringa
Peter Heeringa University Medical Center Groningen
Hubert Kolb
Hubert Kolb Heinrich Heine University Düsseldorf
Hans M.G. Princen
Hans M.G. Princen Netherlands Organisation for Applied Scientific Research
Jaap Keijer
Jaap Keijer Wageningen University & Research
Louis M. Havekes
Louis M. Havekes Leiden University Medical Center
Christian A. Drevon
Christian A. Drevon University of Oslo
Michael Müller
Michael Müller University of East Anglia
Craig E. Wheelock
Craig E. Wheelock Karolinska Institute

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