World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
77
Citations
19238
World Ranking
1840
National Ranking
902

Overview

Lin Leng is affiliated with Yale University in the United States and has an extensive research portfolio primarily focused on immunology and microbiology as well as medicine. Their work covers multiple subfields including immunology, cellular and molecular neuroscience, surgery, pharmacology, and oncology. The scholar has contributed to a broad range of topics, with particular emphasis on macrophage migration inhibitory factor, nuclear receptors and signaling, apelin-related biomedical research, galectins and cancer biology, systemic lupus erythematosus research, cytokine signaling pathways and interactions, and gastroesophageal reflux and treatments.

Among their recent publications are:

  • Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression (2020, Frontiers in Immunology)
  • 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex (2021, Aging Cell)
  • Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting (2020, Nature Communications)
  • Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease (2021, Science Translational Medicine)
  • CD74 as a regulator of transcription in normal B cells (2022, Cell Reports)

Frequent coauthors in Lin Leng's collaborative network include:

  • Richard Bucala (with two separate counts of collaborations, 27 and 10 publications respectively)
  • Marta Piecychna (7 publications)
  • Shaojing Ye (7 publications)
  • Pedro L. Vera (7 publications)

Lin Leng's research has been disseminated through multiple publication venues, showing regular contributions in:

  • The FASEB Journal (3 publications)
  • JCI Insight (3 publications)
  • The Journal of Urology (3 publications)
  • Clinical Rheumatology (2 publications)
  • Frontiers in Public Health (2 publications)

The scientist's work addresses mechanisms of immune modulation and inflammation, with a particular focus on macrophage migration inhibitory factor and related signaling pathways. This is reflected in the diversity of their papers, ranging from cellular receptor function in disease models to lifespan studies in animal models.

Best Publications

  • MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

    Jürgen Bernhagen;Regina Krohn;Hongqi Lue;Julia L Gregory

  • CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.

    Xuerong Shi;Lin Leng;Tian Wang;Wenkui Wang

  • Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

    Edward J. Miller;Ji Li;Lin Leng;Courtney McDonald

  • Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity

    H Lue;M Thiele;J Franz;E Dahl

  • Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells.

    Katherine L. Meyer-Siegler;Kenneth A. Iczkowski;Kenneth A. Iczkowski;Lin Leng;Richard Bucala

  • Macrophage Migration Inhibitory Factor Induces B Cell Survival by Activation of a CD74-CD44 Receptor Complex

    Yael Gore;Diana Starlets;Nitsan Maharshak;Shirly Becker-Herman

  • Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.

    Hongqi Lue;Aphrodite Kapurniotu;Günter Fingerle-Rowson;Thierry Roger

  • Role for macrophage migration inhibitory factor in asthma

    Y. Mizue;S. Ghani;L. Leng;C. McDonald

  • The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

    Melanie Merk;Swen Zierow;Lin Leng;Rituparna Das

  • IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival

    Inbal Binsky;Michal Haran;Diana Starlets;Yael Gore

  • Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes

    K. C. B. Tan;S. W. M. Shiu;W. S. Chow;L. Leng

  • Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

    Yoonsang Cho;Gregg V. Crichlow;Jon J. Vermeire;Lin Leng

  • Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion

    Alvaro Arjona;Harald G. Foellmer;Terrence Town;Lin Leng

  • Macrophage Migration Inhibitory Factor Contributes to the Immune Escape of Ovarian Cancer by Down-Regulating NKG2D

    Mathias Krockenberger;Yvonne Dombrowski;Claudia Weidler;Monika Ossadnik

  • Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

    Dake Qi;Xiaoyue Hu;Xiaohong Wu;Melanie Merk

  • Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74.

    Hongqi Lue;Manfred Dewor;Lin Leng;Richard Bucala

  • MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease

    Lars Verschuren;Teake Kooistra;Jürgen Bernhagen;Peter J. Voshol

  • A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

    Millicent Winner;Jason Meier;Swen Zierow;Beatriz E. Rendon

  • Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation

    Daniel Rittirsch;Michael A. Flierl;Danielle E. Day;Brian A. Nadeau

  • Macrophage migration inhibitory factor promotes intestinal tumorigenesis.

    Jonathan M. Wilson;P. Louise Coletta;Richard J. Cuthbert;Nigel Scott

  • Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)

    Anke Burger-Kentischer;Heike Göbel;Robert Kleemann;Alma Zernecke

Frequent Co-Authors

Richard Bucala
Richard Bucala Yale University
Jürgen Bernhagen
Jürgen Bernhagen Ludwig-Maximilians-Universität München
Elias Lolis
Elias Lolis Yale University
William L. Jorgensen
William L. Jorgensen Yale University
Ruth R. Montgomery
Ruth R. Montgomery Yale University
Christine N. Metz
Christine N. Metz Feinstein Institute for Medical Research
Patty J. Lee
Patty J. Lee Duke University
Huabao Xiong
Huabao Xiong Icahn School of Medicine at Mount Sinai
Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Elena L. Grigorenko
Elena L. Grigorenko University of Houston

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a career in Immunology often intersects with various healthcare professions, making it valuable to explore related online degrees. For those interested in practical nursing roles, finding the easiest LPN programs to get into can be a great starting point. These programs offer accessible pathways to enter the healthcare field quickly.

For advancing clinical roles, knowing which nurse practitioner program is easiest can help streamline the process of becoming a licensed practitioner. This is particularly useful for Immunology graduates seeking specialized patient care roles.

Specialized nurse practitioner programs like psychiatric mental health offer robust career opportunities. Researching PMHNP programs online with best clinical placement ensures hands-on experience and smooth transition into the workforce, a critical factor for professional success.

Budget-conscious students may want to review options for the cheapest psychiatric nurse practitioner programs, balancing cost with quality education. Combining such programs with Immunology knowledge can open doors in mental health and immunological research or clinical care.

Best Scientists Citing Lin Leng

Trending Scientists

Recently Published Articles