Lin Leng spends much of her time researching Macrophage migration inhibitory factor, Cytokine, Immunology, Signal transduction and Cancer research. Her Macrophage migration inhibitory factor study combines topics in areas such as Proinflammatory cytokine, CD74, Endocrinology and Cell biology. Her studies deal with areas such as Apoptosis, Erythropoiesis, Haematopoiesis and Pathogenesis as well as Cytokine.
Lin Leng interconnects Receptor and Bronchoalveolar lavage in the investigation of issues within Immunology. Her research integrates issues of Cell surface receptor, Ischemia and Kinase, Protein kinase A in her study of Signal transduction. Her biological study spans a wide range of topics, including Gene expression, CXC chemokine receptors, Chemokine receptor, Receptor complex and Transforming growth factor beta.
The scientist’s investigation covers issues in Macrophage migration inhibitory factor, Immunology, Cytokine, Internal medicine and Endocrinology. Her Macrophage migration inhibitory factor research is multidisciplinary, incorporating elements of Cancer research, Inflammation, Proinflammatory cytokine, CD74 and Cell biology. In her study, Receptor complex and Kinase is strongly linked to Signal transduction, which falls under the umbrella field of Cancer research.
Her research in Immunology intersects with topics in Macrophage, Allele and Genotype. Her work carried out in the field of Cytokine brings together such families of science as Tumor necrosis factor alpha, Biological activity, CXC chemokine receptors and Monocyte. Her research in Endocrinology tackles topics such as AMPK which are related to areas like Ischemia.
Macrophage migration inhibitory factor, Immunology, Cancer research, Cytokine and Internal medicine are her primary areas of study. Her Macrophage migration inhibitory factor research incorporates themes from Pathogenesis, Inflammation, Proinflammatory cytokine, CD74 and Downregulation and upregulation. Her CD74 study integrates concerns from other disciplines, such as Receptor, CXCR4 and Cell biology.
Her study on Antibody is often connected to Granulomatosis with polyangiitis as part of broader study in Immunology. Lin Leng combines subjects such as SNP, Oxidative stress, Pericyte, Myosin light-chain kinase and Necroptosis with her study of Cytokine. The Internal medicine study combines topics in areas such as Endocrinology and Genotype.
Lin Leng focuses on Macrophage migration inhibitory factor, Immunology, CD74, Cytokine and Cancer research. Her Macrophage migration inhibitory factor study improves the overall literature in Internal medicine. Her Immunology research is multidisciplinary, incorporating perspectives in Signal transduction, Activating transcription factor and Receptor complex.
As part of the same scientific family, Lin Leng usually focuses on CD74, concentrating on Disease and intersecting with Genotype, Multiple sclerosis and Clinically isolated syndrome. The concepts of her Cytokine study are interwoven with issues in Oxidative stress, Hypoxia, CXCR4, Pathogenesis and CXC chemokine receptors. Her Cancer research research includes themes of Tumor microenvironment, T cell, Myeloid-derived Suppressor Cell, Cytotoxic T cell and Immunotherapy.
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MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen;Regina Krohn;Hongqi Lue;Julia L Gregory.
Nature Medicine (2007)
MIF signal transduction initiated by binding to CD74.
Lin Leng;Christine N. Metz;Yan Fang;Jing Xu.
Journal of Experimental Medicine (2003)
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.
Xuerong Shi;Lin Leng;Tian Wang;Wenkui Wang.
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
Edward J. Miller;Ji Li;Lin Leng;Courtney McDonald.
Macrophage migration inhibitory factor.
Lin Leng;Richard Bucala.
Critical Care Medicine (2005)
Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
H Lue;M Thiele;J Franz;E Dahl.
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.
Toshiya Atsumi;Jason Chesney;Christine Metz;Lin Leng.
Cancer Research (2002)
Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells.
Katherine L. Meyer-Siegler;Katherine L. Meyer-Siegler;Kenneth A. Iczkowski;Kenneth A. Iczkowski;Lin Leng;Richard Bucala.
Journal of Immunology (2006)
Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.
Hongqi Lue;Aphrodite Kapurniotu;Günter Fingerle-Rowson;Thierry Roger.
Cellular Signalling (2006)
Macrophage Migration Inhibitory Factor Induces B Cell Survival by Activation of a CD74-CD44 Receptor Complex
Yael Gore;Diana Starlets;Nitsan Maharshak;Shirly Becker-Herman.
Journal of Biological Chemistry (2008)
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