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D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
11079
World Ranking
18265
National Ranking
7464

Overview

Elias Lolis is affiliated with Yale University in the United States. Their research spans several intersecting fields, primarily Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology.

The main topics in Lolis's work include:

  • Macrophage Migration Inhibitory Factor
  • Nuclear Receptors and Signaling
  • SARS-CoV-2 and COVID-19 Research
  • Protein Tyrosine Phosphatases
  • Bioactive Compounds and Antitumor Agents
  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses

Their research covers a range of subfields such as Immunology, Molecular Biology, Infectious Diseases, Cellular and Molecular Neuroscience, and Toxicology.

Lolis has contributed multiple publications in various scientific journals. Frequent publication venues include:

  • Journal of Biological Chemistry
  • Biochemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Signaling
  • Computational and Structural Biotechnology Journal

Selected recent papers authored or co-authored by Lolis feature titles such as:

  • Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel, 2020, Cell chemical biology
  • An allosteric site on MKP5 reveals a strategy for small-molecule inhibition, 2020, Science Signaling
  • A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase, 2021, Journal of Biological Chemistry
  • Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir, 2021, Biochemistry
  • Structural Insights into Binding of Remdesivir Triphosphate within the Replication-Transcription Complex of SARS-CoV-2, 2022, Biochemistry

Frequent collaborators in Lolis's scientific work include:

  • George P. Lisi
  • Víctor S. Batista
  • R. Manjula
  • Georgios Pantouris
  • Federica Maschietto

In addition to peer-reviewed articles, Elias Lolis has contributed to book publications such as "Progress and challenges with therapeutic targeting of chemokine receptors" published by Frontiers Media in 2023.

Best Publications

  • K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

    Murim Choi;Ute I. Scholl;Peng Yue;Peyman Björklund;Peyman Björklund

  • Structure, function, and inhibition of chemokines.

    Elias J. Fernandez;Elias Lolis

  • CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.

    Xuerong Shi;Lin Leng;Tian Wang;Wenkui Wang

  • Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.

    Hong-Wei Sun;Jurgen Bernhagen;Richard Bucala;Elias Lolis

  • The Tautomerase Active Site of Macrophage Migration Inhibitory Factor Is a Potential Target for Discovery of Novel Anti-inflammatory Agents

    Jodi B. Lubetsky;Angeles Dios;Jialian Han;Bayan Aljabari

  • Development of chronic colitis is dependent on the cytokine MIF

    Y. P. de Jong;A. C. Abadia-Molina;A. R. Satoskar;K. Clarke

  • Structure of yeast triosephosphate isomerase at 1.9-A resolution.

    Elias Lolis;Tom Alber;Robert C. Davenport;David Rose

  • Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis.

    Elias Lolis;Gregory A. Petsko

  • Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor

    Melissa Swope;Hong Wei Sun;Paul R. Blake;Elias Lolis

  • The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

    Melanie Merk;Swen Zierow;Lin Leng;Rituparna Das

  • Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

    Yoonsang Cho;Gregg V. Crichlow;Jon J. Vermeire;Lin Leng

  • Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1α, a potent ligand for the HIV-1 “fusin” coreceptor

    Chris Dealwis;Elias J. Fernandez;Darren A. Thompson;Reyna J. Simon

  • Structural and Functional Basis of CXCL12 (Stromal Cell-derived Factor-1α) Binding to Heparin

    James W. Murphy;Yoonsang Cho;Aristidis Sachpatzidis;Chengpeng Fan

  • A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

    Millicent Winner;Jason Meier;Swen Zierow;Beatriz E. Rendon

  • Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.

    Jodi B. Lubetsky;Melissa Swope;Chris Dealwis;Paul Blake

  • CHIRAL DISCRIMINATION IN THE COVALENT BINDING OF BIS(PHENANTHROLINE)DICHLORORUTHENIUM(II) TO B-DNA

    J. K. Barton;E. Lolis

  • Macrophage migration inhibitory factor promotes intestinal tumorigenesis.

    Jonathan M. Wilson;P. Louise Coletta;Richard J. Cuthbert;Nigel Scott

  • Electrophilic catalysis in triosephosphate isomerase : the role of histidine-95

    Elizabeth A. Komives;Louise C. Chang;Elias Lolis;Robert F. Tilton

  • Inhibition of MIF Bioactivity by Rational Design of Pharmacological Inhibitors of MIF Tautomerase Activity

    Angeles Dios;Robert A Mitchell;Bayan Aljabari;Jodi Lubetsky

  • Protein crystallization facilitated by molecularly imprinted polymers.

    Emmanuel Saridakis;Sahir Khurshid;Lata Govada;Quan Phan

Frequent Co-Authors

Richard Bucala
Richard Bucala Yale University
Lin Leng
Lin Leng Yale University
Gregory A. Petsko
Gregory A. Petsko Cornell University
Jürgen Bernhagen
Jürgen Bernhagen Ludwig-Maximilians-Universität München
Karen S. Anderson
Karen S. Anderson Yale University
Victor S. Batista
Victor S. Batista Yale University
Hong-Wei Sun
Hong-Wei Sun National Institutes of Health
Huabao Xiong
Huabao Xiong Icahn School of Medicine at Mount Sinai
Barbara E. Ehrlich
Barbara E. Ehrlich Yale University
Christian Weber
Christian Weber Ludwig-Maximilians-Universität München

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