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Chemistry

D-Index
64
Citations
12679
World Ranking
8153
National Ranking
2353

Overview

John P. Richard is affiliated with the University at Buffalo, State University of New York in the United States. Their research primarily spans the field of biochemistry, genetics, and molecular biology, with a focus on the molecular mechanisms underlying enzyme function and catalysis.

Their work investigates several specific subfields, including:

  • Molecular Biology
  • Materials Chemistry
  • Cell Biology
  • Physiology
  • Organic Chemistry

The main research topics associated with John P. Richard include:

  • Biochemical and Molecular Research
  • Enzyme Structure and Function
  • Pancreatic function and diabetes
  • Protein Structure and Dynamics
  • Enzyme Catalysis and Immobilization
  • Chemical Reaction Mechanisms
  • Erythrocyte Function and Pathophysiology

John P. Richard has contributed extensively to multiple publication venues, with a predominant number of articles in:

  • Biochemistry
  • Journal of the American Chemical Society
  • Journal of Biological Chemistry
  • ACS Catalysis
  • Accounts of Chemical Research

Recent publications by John P. Richard include the following:

  • Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution, 2022, Biochemistry
  • Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase, 2020, ACS Catalysis
  • Origin of Free Energy Barriers of Decarboxylation and the Reverse Process of CO2 Capture in Dimethylformamide and in Water, 2020, Journal of the American Chemical Society
  • Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions, 2021, Journal of the American Chemical Society
  • The Organization of Active Site Side Chains of Glycerol-3-phosphate Dehydrogenase Promotes Efficient Enzyme Catalysis and Rescue of Variant Enzymes, 2020, Biochemistry

John P. Richard frequently collaborates with several co-authors, including:

  • Judith R. Cristobal
  • Rania Hegazy
  • Patrick Fernandez
  • Tiago A. S. Brandão
  • Richard W. Nagorski

Best Publications

  • Formation and Stability of N-Heterocyclic Carbenes in Water: The Carbon Acid pKa of Imidazolium Cations in Aqueous Solution

    Tina L Amyes;Steven T Diver;John P Richard;Felix M Rivas

  • Mechanism for the formation of methylglyoxal from triosephosphates

    J. P. Richard

  • Acid-base catalysis of the elimination and isomerization reactions of triose phosphates

    J.P. Richard

  • Kinetic parameters for the elimination reaction catalyzed by triosephosphate isomerase and an estimation of the reaction's physiological significance

    John P. Richard

  • Physical and Kinetic Analysis of the Cooperative Role of Metal Ions in Catalysis of Phosphodiester Cleavage by a Dinuclear Zn(II) Complex

    Olga Iranzo;Andrey Y. Kovalevsky;Janet R. Morrow;John P. Richard

  • REACTIONS OF SUBSTITUTED 1-PHENYLETHYL CARBOCATIONS WITH ALCOHOLS AND OTHER NUCLEOPHILIC REAGENTS

    J. P. Richard;W. P. Jencks

  • A role for flexible loops in enzyme catalysis.

    M Merced Malabanan;Tina L Amyes;John P Richard

  • Formation and stability of ring-substituted 1-phenylethyl carbocations

    John P. Richard;Marc E. Rothenberg;William P. Jencks

  • Determination of the pKa of Ethyl Acetate: Brønsted Correlation for Deprotonation of a Simple Oxygen Ester in Aqueous Solution

    Tina L. Amyes and;John P. Richard

  • The Generation and Reactions of Quinone Methides

    Maria M. Toteva;John P. Richard

  • Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn(II) catalysts.

    Olga Iranzo;Terry Elmer;John P. Richard;Janet R. Morrow

  • Formation and stability of carbocations and carbanions in water and intrinsic barriers to their reactions.

    John P. Richard;Tina L. Amyes;Maria M. Toteva

  • A SIMPLE RELATIONSHIP BETWEEN CARBOCATION LIFETIME AND REACTIVITY-SELECTIVITY RELATIONSHIPS FOR THE SOLVOLYSIS OF RING-SUBSTITUTED 1-PHENYLETHYL DERIVATIVES

    J. P. Richard;W. P. Jencks

  • Experimental and Computational Determination of the Effect of the Cyano Group on Carbon Acidity in Water

    John P. Richard;Glenn Williams;Jiali Gao

  • Generation and stability of a simple thiol ester enolate in aqueous solution

    Tina L. Amyes;John P. Richard

  • Concerted bimolecular substitution reactions of 1-phenylethyl derivatives

    John P. Richard;William P. Jencks

  • Formation and Stability of Enolates of Acetamide and Acetate Anion: An Eigen Plot for Proton Transfer at α-Carbonyl Carbon

    John P. Richard;Glenn Williams;and AnnMarie C. O'Donoghue;Tina L. Amyes

  • Protein Flexibility and Stiffness Enable Efficient Enzymatic Catalysis

    John P Richard

  • Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts.

    Tina L. Amyes;John P. Richard;James J. Tait

  • Mechanistic Imperatives for Aldose-Ketose Isomerization in Water: Specific, General Base- and Metal Ion-Catalyzed Isomerization of Glyceraldehyde with Proton and Hydride Transfer

    R. W. Nagorski;John P. Richard

  • Formation and Stability of Organic Zwitterions in Aqueous Solution: Enolates of the Amino Acid Glycine and Its Derivatives

    Ana Rios;and Tina L. Amyes;John P. Richard;John P. Richard

Frequent Co-Authors

Tina L. Amyes
Tina L. Amyes University at Buffalo, State University of New York
John A. Gerlt
John A. Gerlt University of Illinois at Urbana-Champaign
Janet R. Morrow
Janet R. Morrow University at Buffalo, State University of New York
William P. Jencks
William P. Jencks Brandeis University
Perry A. Frey
Perry A. Frey University of Wisconsin–Madison
Jiali Gao
Jiali Gao University of Minnesota
Richard L. Schowen
Richard L. Schowen University of Kansas
Steen Steenken
Steen Steenken Max Planck Society
Steven C. Almo
Steven C. Almo Albert Einstein College of Medicine
Merton F. Utter
Merton F. Utter Case Western Reserve University

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