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Chemistry

D-Index
98
Citations
29867
World Ranking
1416
National Ranking
547

Research.com Recognitions

  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Daniel Herschlag is affiliated with Stanford University in the United States and has made significant contributions in the field of biochemistry, genetics, and molecular biology. Their work primarily focuses on molecular biology, with additional contributions in materials chemistry, biomedical engineering, radiation, and endocrinology, diabetes, and metabolism.

The main research topics covered by Daniel Herschlag include:

  • Protein Structure and Dynamics
  • RNA and protein synthesis mechanisms
  • Enzyme Structure and Function
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Biochemical and Molecular Research
  • Microbial Metabolic Engineering and Bioproduction

Key recent papers authored or co-authored by Daniel Herschlag include:

  • How to measure and evaluate binding affinities, 2020, eLife
  • Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics, 2021, Science
  • Parallel molecular mechanisms for enzyme temperature adaptation, 2021, Science
  • Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles, 2020, Proceedings of the National Academy of Sciences
  • Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction, 2020, Nature Communications

Daniel Herschlag frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Biopolymers
  • Science
  • eLife

Frequent co-authors of Daniel Herschlag are:

  • Filip Yabukarski
  • Tzanko Doukov
  • Siyuan Du
  • Daniel A. Mokhtari
  • Polly M. Fordyce

Among the recognitions Daniel Herschlag has received, one notable award is the Fellowship of the American Association for the Advancement of Science (AAAS), awarded in 2005.

Best Publications

  • A single-molecule study of RNA catalysis and folding.

    Xiaowei Zhuang;Laura E. Bartley;Hazen P. Babcock;Rick Russell

  • Catalytic promiscuity and the evolution of new enzymatic activities

    Patrick J O'Brien;Daniel Herschlag

  • RNA chaperones and the RNA folding problem.

    Daniel Herschlag

  • Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins

    Michael T. Woodside;William M. Behnke-Parks;Kevan Larizadeh;Kevin Travers

  • The roles of structural dynamics in the cellular functions of RNAs.

    Laura R Ganser;Megan L Kelly;Daniel Herschlag;Hashim M Al-Hashimi

  • Understanding Nucleic Acid–Ion Interactions

    Jan Lipfert;Sebastian Doniach;Rhiju Das;Daniel Herschlag

  • Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid

    Michael T. Woodside;Peter C. Anthony;William M. Behnke-Parks;Kevan Larizadeh

  • Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

    Jonathan K. Lassila;Jesse G. Zalatan;Daniel Herschlag

  • Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site.

    Daniel Herschlag;Thomas R. Cech

  • SAFA: Semi-automated footprinting analysis software for high-throughput quantification of nucleic acid footprinting experiments

    Rhiju Das;Alain Laederach;Samuel M. Pearlman;Daniel Herschlag

  • Coarse-grained modeling of large RNA molecules with knowledge-based potentials and structural filters

    Magdalena A. Jonikas;Randall J. Radmer;Alain Laederach;Rhiju Das

  • A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction

    Klemens J. Hertel;Daniel Herschlag;Olke C. Uhlenbeck

  • Mechanistic aspects of enzymatic catalysis: lessons from comparison of RNA and protein enzymes.

    Geeta J. Narlikar;Daniel Herschlag

  • Challenges in Enzyme Mechanism and Energetics

    Daniel A. Kraut;Kate S. Carroll;Daniel Herschlag

  • Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.

    Daniel Herschlag;Joseph A. Piccirilli;Thomas R. Cech

  • An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis

    D Herschlag;M Khosla;Z Tsuchihashi;R L Karpel

  • Hydrogen Bonds: Simple after All?

    Daniel Herschlag;Margaux M. Pinney

  • The energetics of hydrogen bonds in model systems : Implications for enzymatic catalysis

    Shu-ou Shan;Stewart Loh;Daniel Herschlag

  • Exploring the folding landscape of a structured RNA.

    Rick Russell;Xiaowei Zhuang;Hazen P. Babcock;Ian S. Millett

  • Quantitative and Comprehensive Decomposition of the Ion Atmosphere around Nucleic Acids

    Yu Bai;Max Greenfeld;Kevin J. Travers;Vincent B. Chu

  • The DEAD Box Protein eIF4A. 1. A Minimal Kinetic and Thermodynamic Framework Reveals Coupled Binding of RNA and Nucleotide

    Jon R. Lorsch;Daniel Herschlag

  • Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.

    Daniel Herschlag

Frequent Co-Authors

Rhiju Das
Rhiju Das Stanford University
Sebastian Doniach
Sebastian Doniach Stanford University
Joseph A. Piccirilli
Joseph A. Piccirilli University of Chicago
Thomas R. Cech
Thomas R. Cech University of Colorado Boulder
William P. Jencks
William P. Jencks Brandeis University
Geeta J. Narlikar
Geeta J. Narlikar University of California, San Francisco
Patrick O. Brown
Patrick O. Brown Stanford University
Steven Chu
Steven Chu Stanford University
William J. Greenleaf
William J. Greenleaf Stanford University
Hashim M. Al-Hashimi
Hashim M. Al-Hashimi Duke University

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