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Biology and Biochemistry

D-Index
72
Citations
20869
World Ranking
6229
National Ranking
2929

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Kevin M. Weeks is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a significant concentration in Molecular Biology.

The main topics addressed in their work include:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Cancer-related molecular mechanisms research
  • DNA and Nucleic Acid Chemistry
  • Molecular Biology Techniques and Applications
  • Bacteriophages and microbial interactions

Frequent coauthors collaborating with Weeks are:

  • Chase A. Weidmann
  • Patrick S. Irving
  • Alain Laederach
  • Anthony M. Mustoe
  • Mark A. Boerneke

Weeks has contributed extensively to several publication venues, including:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Journal of Molecular and Cellular Cardiology
  • Nucleic Acids Research

The following are selected recent papers co-authored by Kevin M. Weeks:

  • Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid (2020, Molecular Cell)
  • Direct detection of RNA modifications and structure using single-molecule nanopore sequencing (2022, Cell Genomics)
  • Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP (2022, Molecular Cell)
  • Analysis of RNA-protein networks with RNP-MaP defines functional hubs on RNA (2020, Nature Biotechnology)
  • Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures (2022, Nucleic Acids Research)

In recognition of their contributions to science, Kevin M. Weeks was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Architecture and secondary structure of an entire HIV-1 RNA genome

    Joseph M. Watts;Kristen K. Dang;Robert J. Gorelick;Christopher W. Leonard

  • RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE).

    Edward J. Merino;Kevin A. Wilkinson;Jennifer L. Coughlan;Kevin M. Weeks

  • Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution.

    Kevin A Wilkinson;Edward J Merino;Kevin M Weeks

  • Accurate SHAPE-directed RNA structure determination

    Katherine E. Deigan;Tian W. Li;David H. Mathews;Kevin M. Weeks

  • RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP)

    Nathan A Siegfried;Steven Busan;Greggory M Rice;Julie A E Nelson

  • Fragments of the HIV-1 Tat protein specifically bind TAR RNA

    Kevin M. Weeks;Christophe Ampe;Steve C. Schultz;Thomas A. Steitz

  • Principles for targeting RNA with drug-like small molecules

    Katherine Deigan Warner;Christine E Hajdin;Kevin M Weeks

  • mRNA structure determines specificity of a polyQ-driven phase separation

    Erin M. Langdon;Yupeng Qiu;Amirhossein Ghanbari Niaki;Grace A. McLaughlin

  • High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states.

    Kevin A Wilkinson;Robert J Gorelick;Suzy M Vasa;Nicolas Guex

  • RNA recognition by Tat-derived peptides: Interaction in the major groove?

    Kevin M. Weeks;Donald M. Crothers

  • A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry.

    Stefanie A. Mortimer;Kevin M. Weeks

  • Selective 2′-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis

    Matthew J Smola;Greggory M Rice;Steven Busan;Nathan A Siegfried

  • Advances in RNA structure analysis by chemical probing.

    Kevin M Weeks

  • Accurate SHAPE-directed RNA secondary structure modeling, including pseudoknots

    Christine E. Hajdin;Stanislav Bellaousov;Wayne Huggins;Christopher W. Leonard

  • Genomic Rna Elements Drive Phase Separation of the Sars-Cov-2 Nucleocapsid

    Christiane Iserman;Christine A. Roden;Mark A. Boerneke;Rachel S.G. Sealfon

  • SHAPE-directed RNA secondary structure prediction.

    Justin T. Low;Kevin M. Weeks

  • Catalysts from synthetic genetic polymers

    Alexander I. Taylor;Vitor B. Pinheiro;Vitor B. Pinheiro;Matthew J. Smola;Alexey S. Morgunov

  • RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction

    José Almeida Cruz;Marc Frédérick Blanchet;Michal Boniecki;Janusz M. Bujnicki;Janusz M. Bujnicki

  • Major groove accessibility of RNA

    Kevin M. Weeks;Donald M. Crothers

  • ShapeFinder: a software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis.

    Suzy M. Vasa;Nicolas Guex;Kevin A. Wilkinson;Kevin M. Weeks

Frequent Co-Authors

Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Feng Ding
Feng Ding Clemson University
Robert J. Gorelick
Robert J. Gorelick National Institutes of Health
Amy S. Gladfelter
Amy S. Gladfelter Duke University
Donald M. Crothers
Donald M. Crothers Yale University
David H. Mathews
David H. Mathews University of Rochester Medical Center
Eric Westhof
Eric Westhof University of Strasbourg
Timothy P. Sheahan
Timothy P. Sheahan University of North Carolina at Chapel Hill
Olga G. Troyanskaya
Olga G. Troyanskaya Princeton University

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