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Microbiology

D-Index
53
Citations
18860
World Ranking
4036
National Ranking
1568

Overview

Timothy P. Sheahan is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on medicine, with significant contributions in infectious diseases, epidemiology, molecular biology, immunology, and animal science and zoology.

The main topics of their work include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Respiratory viral infections research
  • Animal Virus Infections Studies
  • SARS-CoV-2 detection and testing
  • Viral gastroenteritis research and epidemiology
  • Vaccine Coverage and Hesitancy

Their recent notable publications are:

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV, 2020, Nature Communications
  • An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice, 2020, Science Translational Medicine
  • A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures, 2020, Nature
  • A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice, 2020, Cell
  • Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2, 2020, Cell

Frequent co-authors include:

  • Ralph S. Baric
  • Sarah R. Leist
  • Ariane J. Brown
  • Alexandra Schäfer
  • Amy Sims

Sheahan's publications are mainly found in the following venues:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • EClinicalMedicine
  • Science Translational Medicine
  • SSRN Electronic Journal

Their scholarly output demonstrates a focus on emerging infectious diseases, with extensive investigation into antivirals and animal models relevant to coronaviruses. The integration of molecular biology, immunology, and epidemiological study underpins their contributions to understanding and responding to viral pathogens.

Best Publications

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

    Timothy P. Sheahan;Amy C. Sims;Sarah R. Leist;Alexandra Schäfer

  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

    Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery

  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

    Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham

  • An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

    Timothy P. Sheahan;Amy C. Sims;Shuntai Zhou;Rachel L. Graham

  • A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.

    Kenneth H. Dinnon;Sarah R. Leist;Alexandra Schäfer;Caitlin E. Edwards

  • A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.

    Sarah R. Leist;Kenneth H. Dinnon;Alexandra Schäfer;Longping V. Tse

  • Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

    Lisa E. Gralinski;Timothy Patrick Sheahan;Thomas E. Morrison;Vineet D. Menachery;Vineet D. Menachery

  • A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus

    Unknown

  • Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

    Ariane J. Brown;John J. Won;Rachel L. Graham;Kenneth H. Dinnon

  • Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.

    Alexandra C. Walls;Brooke Fiala;Alexandra Schäfer;Samuel Wrenn

  • Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.

    Andrea J. Pruijssers;Andrea J. Pruijssers;Amelia S. George;Amelia S. George;Alexandra Schäfer;Sarah R. Leist

  • A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice

    Anjeanette Roberts;Damon Deming;Christopher D. Paddock;Aaron Cheng

  • SARS-like WIV1-CoV poised for human emergence

    Vineet D. Menachery;Boyd L. Yount;Amy C Sims;Kari Debbink

  • Genomic Rna Elements Drive Phase Separation of the Sars-Cov-2 Nucleocapsid

    Christiane Iserman;Christine A. Roden;Mark A. Boerneke;Rachel S.G. Sealfon

  • Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

    Zhongyu Zhu;Samitabh Chakraborti;Yuxian He;Anjeanette Roberts

  • Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo.

    Alexandra Schäfer;Frauke Muecksch;Julio C.C. Lorenzi;Sarah R. Leist

  • Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

    Unknown

  • Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

    Michelle M. Becker;Rachel Lauren Graham;Eric F. Donaldson;Barry Rockx

  • Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.

    Maria L. Agostini;Andrea J. Pruijssers;James D. Chappell;Jennifer Gribble

  • Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

    Damon Deming;Timothy Sheahan;Mark Heise;Boyd Yount

  • β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells.

    Shuntai Zhou;Collin S Hill;Sanjay Sarkar;Longping V Tse

  • Modeling hepatitis C virus infection using human induced pluripotent stem cells

    Robert E. Schwartz;Kartik Trehan;Linda Andrus;Timothy P. Sheahan

  • Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

    Christiane Iserman;Christine Anne Roden;Mark A. Boerneke;Rachel Sealfon

Frequent Co-Authors

Ralph S. Baric
Ralph S. Baric University of North Carolina at Chapel Hill
Amy C. Sims
Amy C. Sims University of North Carolina at Chapel Hill
Alexandra Schäfer
Alexandra Schäfer Duke University
Mark R. Denison
Mark R. Denison Vanderbilt University Medical Center
Boyd Yount
Boyd Yount University of North Carolina at Chapel Hill
Annelies Wilder-Smith
Annelies Wilder-Smith University of Bern
Tomas Cihlar
Tomas Cihlar Gilead Sciences (United States)
Charles M. Rice
Charles M. Rice Rockefeller University
David R. Martinez
David R. Martinez Yale University
Eric F. Donaldson
Eric F. Donaldson Center for Drug Evaluation and Research

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