World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
83
Citations
29176
World Ranking
968
National Ranking
445

Research.com Recognitions

  • 2012 - Fellow of Alfred P. Sloan Foundation

Overview

Jesse D. Bloom is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily focuses on fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant concentration on subfields including Infectious Diseases, Molecular Biology, Epidemiology, Immunology, and Animal Science and Zoology.

The scientist's work covers a broad range of main topics, featuring extensively in SARS-CoV-2 and COVID-19 research, animal virus infections studies, vaccines and immunoinformatics approaches, monoclonal and polyclonal antibodies research, influenza virus research studies, viral gastroenteritis research and epidemiology, and HIV research and treatment.

Jesse D. Bloom has contributed to numerous publications, with a total of 88 papers appearing in bioRxiv (Cold Spring Harbor Laboratory), 10 in Nature, and seven each in Cell and Viruses. Other notable venues include Virus Evolution for eight publications.

Recent papers delve into key aspects of SARS-CoV-2, including:

  • Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding (2020), published in Cell
  • Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies (2021), published in Cell Host & Microbe
  • Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition (2020), published in Cell Host & Microbe
  • Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays (2020), published in Viruses
  • Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 (2021), published in Science

Frequent co-authors contributing to these works include Tyler N. Starr, Allison J. Greaney, David Veesler, Bernadeta Dadonaite, and Katharine H. D. Crawford, reflecting collaborative efforts in virology and immunology research.

Jesse D. Bloom was named a Fellow of the Alfred P. Sloan Foundation in 2012.

Best Publications

  • Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding.

    Tyler N. Starr;Allison J. Greaney;Allison J. Greaney;Sarah K. Hilton;Sarah K. Hilton;Daniel Ellis

  • Protein stability promotes evolvability.

    Jesse D. Bloom;Sy T. Labthavikul;Christopher R. Otey;Frances H. Arnold

  • Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.

    Allison J. Greaney;Allison J. Greaney;Andrea N. Loes;Andrea N. Loes;Katharine H.D. Crawford;Katharine H.D. Crawford;Tyler N. Starr;Tyler N. Starr

  • Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.

    Allison J. Greaney;Allison J. Greaney;Tyler N. Starr;Pavlo Gilchuk;Seth J. Zost

  • Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays.

    Katharine H D Crawford;Katharine H D Crawford;Rachel Eguia;Adam S Dingens;Andrea N Loes

  • Why highly expressed proteins evolve slowly

    D. Allan Drummond;Jesse D. Bloom;Christoph Adami;Christoph Adami;Claus O. Wilke;Claus O. Wilke

  • Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.

    Tyler N. Starr;Allison J. Greaney;Allison J. Greaney;Amin Addetia;Amin Addetia;William W. Hannon;William W. Hannon

  • Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

    Jesse D. Bloom;Lizhi Ian Gong;David Baltimore

  • Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate.

    Amin Addetia;Katharine H.D. Crawford;Katharine H.D. Crawford;Adam Dingens;Haiying Zhu

  • In the light of directed evolution: pathways of adaptive protein evolution.

    Jesse D. Bloom;Frances H. Arnold

  • SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.

    Tyler N. Starr;Nadine Czudnochowski;Zhuoming Liu;Fabrizia Zatta

  • Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016.

    Tyler N. Starr;Allison J. Greaney;Allison J. Greaney;Adam S. Dingens;Jesse D. Bloom;Jesse D. Bloom;Jesse D. Bloom

  • Evolving strategies for enzyme engineering.

    Jesse D Bloom;Michelle M Meyer;Peter Meinhold;Christopher R Otey

  • Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

    Unknown

  • Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.

    Allison J. Greaney;Tyler N. Starr;Tyler N. Starr;Christopher O. Barnes;Yiska Weisblum

  • Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong;Marc A Suchard;Jesse D Bloom

  • Thermodynamic prediction of protein neutrality

    Jesse D. Bloom;Jonathan J. Silberg;Claus O. Wilke;D. Allan Drummond

  • Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

    Emma B. Hodcroft;Emma B. Hodcroft;Emma B. Hodcroft;Moira Zuber;Sarah Nadeau;Sarah Nadeau;Timothy G. Vaughan;Timothy G. Vaughan

  • Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies

    Allison J. Greaney;Allison J. Greaney;Andrea N. Loes;Andrea N. Loes;Katharine H.D. Crawford;Katharine H.D. Crawford;Tyler N. Starr;Tyler N. Starr

  • Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.

    Jinhui Dong;Seth J Zost;Allison J Greaney;Allison J Greaney;Tyler N Starr

  • Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020

    Emma B. Hodcroft;Emma B. Hodcroft;Moira Zuber;Sarah Nadeau;Sarah Nadeau;Iñaki Comas

  • Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding.

    Tyler N Starr;Allison J Greaney;Allison J Greaney;Sarah K Hilton;Sarah K Hilton;Katharine H D Crawford;Katharine H D Crawford

  • Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate

    Amin Addetia;Katharine Hd Crawford;Adam Dingens;Haiying Zhu

Frequent Co-Authors

Frances H. Arnold
Frances H. Arnold California Institute of Technology
Alexander L. Greninger
Alexander L. Greninger University of Washington
Janet A. Englund
Janet A. Englund Seattle Children's Hospital
Trevor Bedford
Trevor Bedford Fred Hutchinson Cancer Research Center
Helen Y. Chu
Helen Y. Chu University of Washington
David Veesler
David Veesler University of Washington
Claus O. Wilke
Claus O. Wilke The University of Texas at Austin
Scott E. Hensley
Scott E. Hensley University of Pennsylvania
Alexandra C. Walls
Alexandra C. Walls University of Washington
Patrick C. Wilson
Patrick C. Wilson Cornell University

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