2026 Claus O. Wilke: Genetics Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Genetics	64	2732	2586	1199	1123	231	36296

Research.com Recognitions

2019 - Fellow of American Physical Society (APS) Citation For discovering that biophysical constraints are a primary driver of protein sequence evolution

Overview

Claus O. Wilke is affiliated with The University of Texas at Austin in the United States. Their research output spans primarily in the field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Molecular Biology as a subfield. Other notable subfields in their work include Ecology, Genetics, Computational Theory and Mathematics, and Infectious Diseases.

The scientist's research topics cover a range of subjects within biology and computational methods, including:

RNA and protein synthesis mechanisms
Genomics and phylogenetic studies
Machine learning in bioinformatics
Bacteriophages and microbial interactions
Protein structure and dynamics
Chemical synthesis and analysis
Bacterial genetics and biotechnology

Wilke has contributed numerous papers to various publication venues, including significant contributions to bioRxiv (Cold Spring Harbor Laboratory) with 25 publications, Zenodo (CERN European Organization for Nuclear Research) with 5, Proceedings of the National Academy of Sciences with 4, The Journal of Open Source Software with 4, and Scientific Reports with 3.

Recent papers authored or coauthored by Wilke feature topics relevant to protein function prediction, gene humanization, and CRISPR systems:

"BACPHLIP: predicting bacteriophage lifestyle from conserved protein domains" (2021), published in PeerJ
"colorspace: A Toolbox for Manipulating and Assessing Colors and Palettes" (2020), published in Journal of Statistical Software
"Metagenomic discovery of CRISPR-associated transposons" (2021), published in Proceedings of the National Academy of Sciences
"Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs" (2020), published in PLoS Biology
"Using machine learning to predict the effects and consequences of mutations in proteins" (2023), published in Current Opinion in Structural Biology

Wilke regularly collaborates with a core group of frequent coauthors, including Adam J. Hockenberry, Bryan W. Davies, Alexis M. Hill, Andrew D. Ellington, and Aaron L. Feller, reflecting ongoing partnerships across their research projects.

In 2019, Claus O. Wilke was recognized as a Fellow of the American Physical Society (APS) with a citation acknowledging the discovery that biophysical constraints are a primary driver of protein sequence evolution.

Best Publications

Welcome to the Tidyverse

Hadley Wickham;Mara Averick;Jennifer Bryan;Winston Chang

19508
Citations
Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

D. Allan Drummond;Claus O. Wilke

1163
Citations
Why highly expressed proteins evolve slowly

D. Allan Drummond;Jesse D. Bloom;Christoph Adami;Christoph Adami;Claus O. Wilke;Claus O. Wilke

958
Citations
Evolution of digital organisms at high mutation rates leads to survival of the flattest

Claus O. Wilke;Jia Lan Wang;Charles Ofria;Richard E. Lenski

796
Citations
The evolutionary consequences of erroneous protein synthesis

D. Allan Drummond;Claus O. Wilke

564
Citations
A Single Determinant Dominates the Rate of Yeast Protein Evolution

D. Allan Drummond;Alpan Raval;Alpan Raval;Claus O. Wilke

484
Citations
Systematic humanization of yeast genes reveals conserved functions and genetic modularity

Aashiq H. Kachroo;Jon M. Laurent;Christopher M. Yellman;Austin G. Meyer

477
Citations
Maximum allowed solvent accessibilites of residues in proteins.

Matthew Z. Tien;Austin G. Meyer;Austin G. Meyer;Dariya K. Sydykova;Stephanie J. Spielman

428
Citations
Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4+ T Cells

Justin R. Bailey;Ahmad R. Sedaghat;Tara Kieffer;Timothy Brennan

416
Citations
Thermodynamic prediction of protein neutrality

Jesse D. Bloom;Jonathan J. Silberg;Claus O. Wilke;D. Allan Drummond

412
Citations
A Universal Trend of Reduced mRNA Stability near the Translation-Initiation Site in Prokaryotes and Eukaryotes

Wanjun Gu;Tong Zhou;Claus O. Wilke

368
Citations
Theory of Lethal Mutagenesis for Viruses

J. J. Bull;R. Sanjuán;C. O. Wilke

339
Citations
Quasispecies theory in the context of population genetics

Claus O Wilke;Claus O Wilke

321
Citations
Causes of evolutionary rate variation among protein sites

Julian Echave;Stephanie J. Spielman;Claus O. Wilke

276
Citations
Translationally Optimal Codons Associate with Structurally Sensitive Sites in Proteins

Tong Zhou;Mason Weems;Claus O. Wilke

223
Citations
The traveling wave approach to asexual evolution: Muller’s ratchet and speed of adaptation

Igor M. Rouzine;Éric Brunet;Claus O. Wilke

198
Citations
Structural Determinants of the Rate of Protein Evolution in Yeast

Jesse D. Bloom;D. Allan Drummond;Frances H. Arnold;Claus O. Wilke

190
Citations
BACPHLIP: predicting bacteriophage lifestyle from conserved protein domains.

Adam J Hockenberry;Claus O Wilke

182
Citations
Thermodynamics of Neutral Protein Evolution

Jesse D. Bloom;Alpan Raval;Claus O. Wilke

174
Citations
The speed of adaptation in large asexual populations.

Claus O. Wilke

167
Citations

Frequent Co-Authors

Thomas Martinetz University of Lübeck

Robert F. Siliciano Johns Hopkins University School of Medicine

Edward M. Marcotte The University of Texas at Austin

Jeffrey E. Barrick The University of Texas at Austin

Frances H. Arnold California Institute of Technology

Jesse D. Bloom Fred Hutchinson Cancer Research Center

Charles Ofria Michigan State University

James J. Bull University of Idaho

Richard E. Lenski Michigan State University

Janet D. Siliciano Johns Hopkins University School of Medicine

External Links

Wikipedia of Claus O. Wilke Personal website of Claus O. Wilke

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