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Microbiology

D-Index
69
Citations
29278
World Ranking
1991
National Ranking
842

Overview

Janet D. Siliciano is affiliated with Johns Hopkins University School of Medicine in the United States. Their research focuses primarily on the fields of Immunology and Microbiology, as well as Medicine. Key subfields include Virology, Immunology, Infectious Diseases, Epidemiology, and Radiology, Nuclear Medicine and Imaging.

The scientist's work centers extensively on HIV research and treatment, including immune cell function and interaction, HIV/AIDS research and interventions, and HIV/AIDS drug development and treatment. Additional topics covered in their research include cytomegalovirus and herpesvirus research, monoclonal and polyclonal antibodies research, and T-cell and B-cell immunology.

Recent publications by Janet D. Siliciano highlight their contributions to understanding HIV reservoirs, proviral DNA decay, and immune dynamics in infected individuals. Notable papers include:

  • Distinct viral reservoirs in individuals with spontaneous control of HIV-1, 2020, Nature
  • Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy, 2020, JCI Insight
  • Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo, 2020, Journal of Clinical Investigation
  • Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy, 2020, The Journal of Infectious Diseases
  • Recommendations for measuring HIV reservoir size in cure-directed clinical trials, 2020, Nature Medicine

Janet D. Siliciano has collaborated frequently with a number of researchers, including Robert F. Siliciano, Francesco R. Simonetti, Steven G. Deeks, Emily J. Fray, and Jun Lai.

Their work has been published extensively across various scientific venues. The most frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, The Journal of Infectious Diseases, and Science Translational Medicine.

Best Publications

  • Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

    Diana Finzi;Joel N Blankson;Janet M Siliciano;Joseph Bernard Margolick

  • Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

    Christine E. Canman;Dae Sik Lim;Karlene A. Cimprich;Yoichi Taya

  • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

    Janet D Siliciano;Joleen Kajdas;Diana Finzi;Thomas C Quinn;Thomas C Quinn

  • Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

    Ya Chi Ho;Liang Shan;Nina N. Hosmane;Jeffrey Wang

  • DNA DAMAGE INDUCES PHOSPHORYLATION OF THE AMINO TERMINUS OF P53

    Janet D. Siliciano;Christine E. Canman;Yoichi Taya;Kazuyasu Sakaguchi

  • Defective proviruses rapidly accumulate during acute HIV-1 infection.

    Katherine M. Bruner;Alexandra J. Murray;Ross A. Pollack;Mary G. Soliman

  • A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

    Katherine M. Bruner;Katherine M. Bruner;Zheng Wang;Francesco R. Simonetti;Alexandra M. Bender

  • Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

    Susanne Eriksson;Erin H. Graf;Viktor Dahl;Matthew C. Strain

  • Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

    Kai Deng;Mihaela Pertea;Anthony Rongvaux;Leyao Wang

  • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

    C Korin Bullen;Gregory M Laird;Christine M Durand;Janet D Siliciano

  • A vinculin-containing cortical lattice in skeletal muscle : transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma

    Jose V. Pardo;Janet D'Angelo Siliciano;Susan W. Craig

  • HIV-1 Integration Landscape during Latent and Active Infection

    Lillian B. Cohn;Israel T. Silva;Israel T. Silva;Thiago Y. Oliveira;Rafael A. Rosales

  • International AIDS Society global scientific strategy: towards an HIV cure 2016

    Steven G Deeks;Sharon R Lewin;Anna Laura Ross;Jintanat Ananworanich

  • Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

    Gregory M. Laird;C. Korin Bullen;Daniel I.S. Rosenbloom;Alyssa R. Martin

  • Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes.

    Yefei Han;Kara Lassen;Daphne Monie;Ahmad R. Sedaghat

  • Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4+ T Cells

    Justin R. Bailey;Ahmad R. Sedaghat;Tara Kieffer;Timothy Brennan

  • Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

    Nina N. Hosmane;Kyungyoon J. Kwon;Katherine M. Bruner;Adam A. Capoferri

  • itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2

    Janet D. Siliciano;Theresa A. Morrow;Stephen V. Desiderio

  • Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient

    Steven A. Yukl;Eli Boritz;Michael Busch;Christopher Bentsen

  • Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals.

    Janet D. Siliciano;Robert F. Siliciano

Frequent Co-Authors

Robert F. Siliciano
Robert F. Siliciano Johns Hopkins University School of Medicine
Thomas C. Quinn
Thomas C. Quinn Johns Hopkins University
Steven G. Deeks
Steven G. Deeks University of California, San Francisco
Joseph B. Margolick
Joseph B. Margolick Johns Hopkins University
Joel N. Blankson
Joel N. Blankson Johns Hopkins University School of Medicine
Douglas D. Richman
Douglas D. Richman University of California, San Diego
Rebecca Hoh
Rebecca Hoh University of California, San Francisco
Hung-Chih Yang
Hung-Chih Yang National Taiwan University
Ronald J. Bosch
Ronald J. Bosch Harvard University
Claus O. Wilke
Claus O. Wilke The University of Texas at Austin

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