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Microbiology
Spain
2026
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Medicine
Spain
2023

D-Index & Metrics

Microbiology

D-Index
107
Citations
39436
World Ranking
282
National Ranking
6

Medicine

D-Index
107
Citations
39454
World Ranking
6294
National Ranking
91

Research.com Recognitions

  • 2026 - Research.com Microbiology in Spain Leader Award
  • 2025 - Research.com Microbiology in Spain Leader Award
  • 2023 - Research.com Medicine in Spain Leader Award
  • 2022 - Research.com Microbiology in Spain Leader Award
  • 2020 - Member of the National Academy of Sciences
  • 1998 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Esteban Domingo is affiliated with the Centro de Biología Molecular Severo Ochoa in Spain. Their research focuses primarily on Medicine and Biochemistry, Genetics and Molecular Biology, with substantial contributions to subfields including Infectious Diseases, Molecular Biology, Genetics, Ecology, and Hepatology.

The scientist's main topics of study include:

  • Evolution and Genetic Dynamics
  • Hepatitis C virus research
  • Plant Virus Research Studies
  • Bacteriophages and microbial interactions
  • SARS-CoV-2 and COVID-19 Research
  • Hepatitis B Virus Studies
  • HIV/AIDS drug development and treatment

Frequent co-authors of Esteban Domingo include:

  • Celia Perales
  • Carlos García-Crespo
  • María Eugenia Soria
  • Ana Isabel de Ávila
  • Brenda Martínez-González

Publications have appeared repeatedly in venues such as:

  • Journal of Virology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • Proceedings of the National Academy of Sciences
  • Frontiers in Microbiology

Selected recent papers include:

  • "Mutation Rates, Mutation Frequencies, and Proofreading-Repair Activities in RNA Virus Genetics" (2021, Viruses)
  • "Historical Perspective on the Discovery of the Quasispecies Concept" (2021, Annual Review of Virology)
  • "A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbations" (2020, Infection Genetics and Evolution)
  • "SARS-CoV-2 Mutant Spectra at Different Depth Levels Reveal an Overwhelming Abundance of Low Frequency Mutations" (2022, Pathogens)
  • "In vitro Selection of High Affinity DNA and RNA Aptamers that Detect Hepatitis C Virus Core Protein of Genotypes 1 to 4 and Inhibit Virus Production in Cell Culture" (2022, Journal of Molecular Biology)

Esteban Domingo has contributed to the publication of the book "Viral Fitness and Evolution" (2023) released by Springer Science+Business Media.

The scientist has been recognized with memberships in notable scientific organizations:

  • National Academy of Sciences (2020)
  • Academia Europaea (1998)
  • European Molecular Biology Organization (EMBO)

Best Publications

  • RNA virus mutations and fitness for survival

    E. Domingo;J. J. Holland

  • Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

    M. A. García;J. Gil;I. Ventoso;S. Guerra

  • Viral Quasispecies Evolution

    Esteban Domingo;Julie Sheldon;Celia Perales

  • Biological and biomedical implications of the co-evolution of pathogens and their hosts

    Mark E. J. Woolhouse;Joanne P. Webster;Esteban Domingo;Brian Charlesworth

  • Origin and evolution of viruses

    John Holland;Esteban Domingo

  • Nucleotide sequence heterogeneity of an RNA phage population

    Esteban Domingo;Donna Sabo;Tadatsugu Taniguchi;Charles Weissmann

  • The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance — a review

    Esteban Domingo;Encarnación Martínez-Salas;Francisco Sobrino;Juan Carlos de la Torre

  • Basic concepts in RNA virus evolution.

    Esteban Domingo;Cristina Escarmís;Noemi Sevilla;Andres Moya

  • Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase.

    David A. Steinhauer;Esteban Domingo;John J. Holland

  • Evolution of foot-and-mouth disease virus.

    Esteban Domingo;Cristina Escarmı́s;Eric Baranowski;Carmen M Ruiz-Jarabo

  • Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet

    Elizabeth Duarte;David Clarke;Andres Moya;Esteban Domingo

  • Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture.

    Francisco Sobrino;Mercedes Dávila;Juan Ortín;Esteban Domingo

  • Viral quasispecies

    Unknown

  • Evolution of cell recognition by viruses.

    Eric Baranowski;Carmen M. Ruiz-Jarabo;Esteban Domingo

  • Viruses as quasispecies: biological implications.

    E. Domingo;V. Martín;C. Perales;A. Grande-Pérez

  • Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity

    Saleta Sierra;Mercedes Dávila;Pedro R. Lowenstein;Esteban Domingo

  • The structure and antigenicity of a type C foot-and-mouth disease virus

    S Lea;J Hernéndez;W Blakemore;E Brocchi

  • The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate.

    Eduard Batschelet;Esteban Domingo;Charles Weissmann

  • Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis.

    John J. Holland;Esteban Domingo;Juan Carlos de la Torre;David A. Steinhauer

  • Exponential increases of RNA virus fitness during large population transmissions

    Isabel S. Novella;Elizabeth A. Duarte;Santiago F. Elena;Andres Moya

  • Foot-and-mouth disease virus.

    Esteban Domingo;Eric Baranowski;Cristina Escarmı́s;Francisco Sobrino

Frequent Co-Authors

Cristina Escarmís
Cristina Escarmís Spanish National Research Council
Mauricio G. Mateu
Mauricio G. Mateu Spanish National Research Council
Josep Quer
Josep Quer Instituto de Salud Carlos III
Francisco Sobrino
Francisco Sobrino Spanish National Research Council
John J. Holland
John J. Holland University of California, San Diego
Juan Ignacio Esteban
Juan Ignacio Esteban Vall d'Hebron Hospital Universitari
David Andreu
David Andreu Pompeu Fabra University
Andrés Moya
Andrés Moya University of Valencia
Miguel Angel Martínez
Miguel Angel Martínez Autonomous University of Barcelona
Ernest Giralt
Ernest Giralt University of Barcelona

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