His scientific interests lie mostly in Virology, Molecular biology, Virus, Polymerase and Cell biology. His research in Virology intersects with topics in RNA and Apoptosis. His Molecular biology research is multidisciplinary, incorporating perspectives in Cell culture, Messenger RNA, Gene and Protein G.
His work on Orthomyxoviridae and Influenza A virus subtype H5N1 as part of general Virus research is often related to H5N1 genetic structure and Reassortant Viruses, thus linking different fields of science. His studies in Polymerase integrate themes in fields like Ribonucleoprotein, Protein subunit, Nucleoprotein and Transcription. His Viral replication research incorporates elements of Influenza A virus and Viral protein.
Virology, Molecular biology, Virus, RNA and Polymerase are his primary areas of study. His work on Influenza A virus and Viral replication as part of general Virology study is frequently linked to Pandemic, therefore connecting diverse disciplines of science. His Molecular biology research is multidisciplinary, incorporating elements of RNA-dependent RNA polymerase, Orthomyxoviridae and Protein subunit, Gene, Messenger RNA.
His Virus study combines topics in areas such as Cell culture, Recombinant DNA, Interferon, Mutant and Microbiology. His work carried out in the field of Polymerase brings together such families of science as Ribonucleoprotein, Nuclear transport, RNA polymerase and Binding site. Juan Ortín interconnects Nucleoprotein, MRNA transport, Cell biology, Immunoelectron microscopy and Transcription in the investigation of issues within Ribonucleoprotein.
Juan Ortín focuses on Virology, Virus, Influenza A virus, Viral replication and RNA. His biological study spans a wide range of topics, including Regulator, Genetics and Intron. Virus is often connected to Interferon in his work.
His Influenza A virus study incorporates themes from Viral evolution, Innate immune system and Microbiology. The study incorporates disciplines such as Unfolded protein response, Transcription and Cell biology in addition to RNA. He has researched Ribonucleoprotein in several fields, including VP40 and Polymerase.
Juan Ortín mostly deals with Virology, Viral replication, RNA, Virus and Influenza A virus. As part of his studies on Virology, he often connects relevant areas like Genetics. His research investigates the connection between Viral replication and topics such as Gene that intersect with problems in Innate immune system.
His research investigates the connection with RNA and areas like Transcription which intersect with concerns in Intron. His Ribonucleoprotein research incorporates themes from VP40, Cell biology, AU-rich element, RNA-binding protein and Gene silencing. His RNA silencing study combines topics from a wide range of disciplines, such as Signal recognition particle RNA, Molecular biology, Translational regulation and Mutant protein.
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The multifunctional NS1 protein of influenza A viruses.
Benjamin Geoffrey Hale;Richard Edward Randall;J Ortin;David Jackson.
Journal of General Virology (2008)
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance — a review
Esteban Domingo;Encarnación Martínez-Salas;Francisco Sobrino;Juan Carlos de la Torre.
The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2.
Delphine Guilligay;Franck Tarendeau;Patricia Resa-Infante;Rocío Coloma.
Nature Structural & Molecular Biology (2008)
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.
P Fortes;A Beloso;J Ortín.
The EMBO Journal (1994)
Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model
Taronna R. Maines;Li-Mei Chen;Yumiko Matsuoka;Hualan Chen.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture.
Francisco Sobrino;Mercedes Dávila;Juan Ortín;Esteban Domingo.
The mammalian Staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: Implications for its involvement in mRNA transport
Michael A. Kiebler;Indradeo Hemraj;Paul Verkade;Martin Köhrmann.
The Journal of Neuroscience (1999)
The Structure of Native Influenza Virion Ribonucleoproteins
Rocío Arranz;Rocío Coloma;Rocío Coloma;Francisco Javier Chichón;José Javier Conesa.
Eukaryotic Translation Initiation Factor 4GI Is a Cellular Target for NS1 Protein, a Translational Activator of Influenza Virus
Tomás Aragón;Susana de la Luna;Isabel Novoa;Luis Carrasco.
Molecular and Cellular Biology (2000)
The structure of a biologically active influenza virus ribonucleoprotein complex
Rocío Coloma;José M. Valpuesta;Rocío Arranz;José L. Carrascosa.
PLOS Pathogens (2009)
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