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Genetics

D-Index
65
Citations
18836
World Ranking
2677
National Ranking
38

Overview

Juan Valcárcel is affiliated with the Institució Catalana de Recerca i Estudis Avançats in Spain. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a strong emphasis on Molecular Biology. Additional subfields include Genetics, Pathology and Forensic Medicine, Cell Biology, and Cancer Research.

The scientist's work covers several main topics related to RNA, including:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA regulation and disease
  • RNA Interference and Gene Delivery
  • Neurogenetic and Muscular Disorders Research
  • Pancreatic function and diabetes

Juan Valcárcel has published extensively, with recent notable papers:

  • RNA-binding proteins in human genetic disease (2020), published in Nature Reviews Genetics
  • Roles and mechanisms of alternative splicing in cancer - implications for care (2020), published in Nature Reviews Clinical Oncology
  • Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects (2022), published in Nature Reviews Genetics
  • Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome (2024), published in Science
  • Mutations primarily alter the inclusion of alternatively spliced exons (2020), published in eLife

Frequent coauthors in their research include Sophie Bonnal, Estefanía Mancini, Fátima Gebauer, Thomas Schwarzl, and Matthias W. Hentze.

The main venues where Juan Valcárcel's work has appeared most frequently are:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Molecular Cell

Best Publications

  • Alternative pre-mRNA splicing: the logic of combinatorial control.

    Christopher W.J Smith;Juan Valcárcel

  • Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins

    Ravinder Singh;Juan Valcarcel;Michael R. Green

  • Alternative splicing and genome complexity.

    David Brett;Heike Pospisil;Juan Valcárcel;Jens Reich

  • Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

    Fran Supek;Fran Supek;Belén Miñana;Juan Valcárcel;Juan Valcárcel;Toni Gabaldón;Toni Gabaldón

  • Nucleosome positioning as a determinant of exon recognition.

    Hagen Tilgner;Christoforos Nikolaou;Sonja Althammer;Michael Sammeth

  • Roles and mechanisms of alternative splicing in cancer - implications for care.

    Sophie C. Bonnal;Irene López-Oreja;Irene López-Oreja;Juan Valcárcel;Juan Valcárcel

  • RNA-binding proteins in human genetic disease.

    Fátima Gebauer;Thomas Schwarzl;Juan Valcárcel;Juan Valcárcel;Matthias W. Hentze

  • The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.

    Juan Valcárcel;Ravinder Singh;Phillip D. Zamore;Michael R. Green

  • The spliceosome as a target of novel antitumour drugs

    Sophie Bonnal;Luisa Vigevani;Juan Valcárcel;Juan Valcárcel

  • Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

    José María Izquierdo;Nuria Majós;Sophie Bonnal;Concepción Martínez

  • Optimization of oligonucleotide-based DNA microarrays.

    Angela Relógio;Christian Schwager;Alexandra Richter;Wilhelm Ansorge

  • Interaction of U2AF65 RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

    Juan Valcárcel;Rajesh K. Gaur;Ravinder Singh;Michael R. Green

  • Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG.

    Livia Merendino;Sabine Guth;Daniel Bilbao;Concepción Martínez

  • The SR protein family: pleiotropic functions in pre-mRNA splicing

    Juan Valcárcel;Michael R. Green

  • RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

    Elias G. Bechara;Endre Sebestyén;Isabella Bernardis;Eduardo Eyras

  • U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction

    Jan Fleckner;Meng Zhang;Juan Valcarcel;Michael R. Green

  • The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.

    Patrik Förch;Oscar Puig;Nancy Kedersha;Concepción Martínez

  • Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

    Anna Corrionero;Belén Miñana;Juan Valcárcel

  • Building specificity with nonspecific RNA-binding proteins.

    Ravinder Singh;Juan Valcárcel

  • The Spliceosome: The Ultimate RNA Chaperone and Sculptor.

    Panagiotis Papasaikas;Juan Valcárcel

Frequent Co-Authors

Ben Lehner
Ben Lehner Wellcome Sanger Institute
Eduardo Eyras
Eduardo Eyras Pompeu Fabra University
Juan Ortín
Juan Ortín Spanish National Research Council
Roderic Guigó
Roderic Guigó Pompeu Fabra University
Michael Sattler
Michael Sattler Technical University of Munich
Matthias W. Hentze
Matthias W. Hentze European Molecular Biology Laboratory
Adrian R. Krainer
Adrian R. Krainer Cold Spring Harbor Laboratory
Luiz O. F. Penalva
Luiz O. F. Penalva The University of Texas Health Science Center at San Antonio
Maria Carmo-Fonseca
Maria Carmo-Fonseca University of Lisbon
Toni Gabaldón
Toni Gabaldón Institució Catalana de Recerca i Estudis Avançats

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