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Reinhard Lührmann

Reinhard Lührmann

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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Molecular Biology

D-Index
124
Citations
53430
World Ranking
229
National Ranking
18

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2002 - Member of Academia Europaea
  • 2001 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Reinhard Lührmann is affiliated with the Max Planck Society in Germany. Their work is primarily situated within the fields of biochemistry, genetics, and molecular biology, with a focus on molecular biology as a specific subfield.

The researcher's recent paper is titled Unbiased screen of human transcriptome reveals an unexpected role of 3'UTRs in translation initiation, published in 2021 in bioRxiv (Cold Spring Harbor Laboratory). This study has attracted citations discussing aspects of RNA and translation mechanisms.

The main topics covered in the research include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms

Reinhard Lührmann has frequently collaborated with the following co-authors:

  • Yun Yang
  • Xiaojuan Fan
  • Yanwen Ye
  • Chuyun Chen
  • Sebastian Ludwig

The primary publication venue for recent work is:

  • bioRxiv (Cold Spring Harbor Laboratory)

Over the course of their career, Reinhard Lührmann has received several recognitions which include:

  • Member of Academia Europaea (2002)
  • German National Academy of Sciences Leopoldina (2001), specifically within Biochemistry and Biophysics
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • The Spliceosome: Design Principles of a Dynamic RNP Machine

    Markus C. Wahl;Cindy L. Will;Reinhard Lührmann

  • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

    Javier Martinez;Agnieszka Patkaniowska;Henning Urlaub;Reinhard Lührmann

  • Spliceosome structure and function.

    Cindy L. Will;Reinhard Lührmann

  • The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.

    Utz Fischer;Jochen Huber;Wilbert C Boelens;Lain W Mattajt

  • Spliceosomal UsnRNP biogenesis, structure and function.

    Cindy L Will;Reinhard Lührmann

  • Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

    Jhumku D. Kohtz;Sharon F. Jamison;Cindy L. Will;Ping Zuo;Ping Zuo

  • Identification of Novel Argonaute-Associated Proteins

    Gunter Meister;Markus Landthaler;Lasse Peters;Po Yu Chen

  • Macromolecular-scale resolution in biological fluorescence microscopy.

    G Donnert;J Keller;R Medda;M A Andrei

  • Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A) + RNA and nuclear pores

    Alexandra Segref;Kishore Sharma;Valérie Doye;Andrea Hellwig

  • GraFix: sample preparation for single-particle electron cryomicroscopy

    Berthold Kastner;Niels Fischer;Monika Mariola Golas;Bjoern Sander

  • The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci

    Dierk Ingelfinger;Donna J Arndt-Jovin;Reinhard Lührmann;Tilmann Achsel

  • Isolation of an active step I spliceosome and composition of its RNP core.

    Sergey Bessonov;Maria Anokhina;Cindy L. Will;Henning Urlaub

  • Structure of spliceosomal snRNPs and their role in pre-mRNA splicing.

    Reinhard Lührmann;Berthold Kastner;Montserrat Bach

  • Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

    Christian Kambach;Stefan Walke;Robert Young;Johanna M. Avis

  • A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

    Maria Alexandra Andrei;Dierk Ingelfinger;Rainer Heintzmann;Tilmann Achsel

  • Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome

    Evgeny M. Makarov;Olga V. Makarova;Henning Urlaub;Marc Gentzel

  • Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.

    Hero Brahms;Lydie Meheus;Veronique De Brabandere;Utz Fischer

  • A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.

    Tilmann Achsel;Hero Brahms;Berthold Kastner;Angela Bachi

  • The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

    Angela Krämer;Walter Keller;Bernd Appel;Reinhard Lührmann

  • Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome

    Anna Hegele;Atanas Kamburov;Arndt Grossmann;Chrysovalantis Sourlis

Frequent Co-Authors

Cindy L. Will
Cindy L. Will Max Planck Society
Henning Urlaub
Henning Urlaub University of Göttingen
Holger Stark
Holger Stark Max Planck Society
Matthias Wilm
Matthias Wilm University College Dublin
Markus C. Wahl
Markus C. Wahl Freie Universität Berlin
Ralf Ficner
Ralf Ficner University of Göttingen
Thomas Tuschl
Thomas Tuschl Rockefeller University
Utz Fischer
Utz Fischer University of Würzburg
Alexander Gottschalk
Alexander Gottschalk Michigan State University

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