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Molecular Biology

D-Index
65
Citations
17602
World Ranking
1661
National Ranking
117

Overview

Utz Fischer is affiliated with the University of Würzburg in Germany and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research spans several interconnected subfields including molecular biology, genetics, atomic and molecular physics and optics, virology, and cancer research. The scientist has a notable focus on RNA research and splicing, RNA modifications and cancer, neurogenetic and muscular disorders, strong light-matter interactions, poxvirus research and outbreaks, RNA and protein synthesis mechanisms, and bacteriophages and microbial interactions.

Their publication record includes several recent papers, featuring work published between 2020 and 2022 in respected journals. These include:

  • The SARS-CoV-2 RNA-protein interactome in infected human cells (2020, Nature Microbiology)
  • Room temperature organic exciton-polariton condensate in a lattice (2020, Nature Communications)
  • The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness (2020, Molecular Cell)
  • LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice (2020, Molecular Cell)
  • Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA (2022, Nature)

Utz Fischer has frequently published in several scientific venues, including:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Molecular Cell
  • Cell Reports

Collaboration has been a significant aspect of Fischer's work. Frequent co-authors include Clemens Grimm, Jürgen Ohmer, Cornelius Schneider, Christian Schneider, and Archana Bairavasundaram Prusty. The number of joint publications with these colleagues varies, indicating ongoing cooperative research activities.

The main research topics central to their work are:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Neurogenetic and Muscular Disorders Research
  • Strong Light-Matter Interactions
  • Poxvirus research and outbreaks
  • RNA and protein synthesis mechanisms
  • Bacteriophages and microbial interactions

In total, Utz Fischer's scholarly contributions amount to over seventy publications in the primary domain of biochemistry, genetics, and molecular biology, with an emphasis on RNA-related processes and disease mechanisms.

Best Publications

  • The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.

    Utz Fischer;Jochen Huber;Wilbert C Boelens;Lain W Mattajt

  • The SMN–SIP1 Complex Has an Essential Role in Spliceosomal snRNP Biogenesis

    Utz Fischer;Qing Liu;Gideon Dreyfuss

  • The Spinal Muscular Atrophy Disease Gene Product, SMN, and Its Associated Protein SIP1 Are in a Complex with Spliceosomal snRNP Proteins

    Qing Liu;Utz Fischer;Fan Wang;Gideon Dreyfuss

  • Evidence that fragile X mental retardation protein is a negative regulator of translation

    Bernhard Laggerbauer;Dirk Ostareck;Eva-Maria Keidel;Antje Ostareck-Lederer

  • HIV‐1 infection of non‐dividing cells: evidence that the amino‐terminal basic region of the viral matrix protein is important for Gag processing but not for post‐entry nuclear import

    Ron A.M. Fouchier;Barbara E. Meyer;James H.M. Simon;Utz Fischer

  • Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.

    Hero Brahms;Lydie Meheus;Veronique De Brabandere;Utz Fischer

  • Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.

    Gunter Meister;Christian Eggert;Dirk Bühler;Hero Brahms

  • SMN tudor domain structure and its interaction with the Sm proteins.

    Philipp Selenko;Remco Sprangers;Gunter Stier;Dirk Bühler

  • Water channels in the plant plasma membrane cloned by immunoselection from a mammalian expression system

    Werner Kammerloher;Utz Fischer;Gerd P. Piechottka;Anton R. Schaffner

  • A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs.

    Gunter Meister;Dirk Bühler;Ramesh Pillai;Friedrich Lottspeich

  • Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA

    U. Fischer;S. Meyer;M. Teufel;C. Heckel

  • Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.

    Dirk Bühler;Veronica Raker;Reinhard Lührmann;Utz Fischer

  • A Role for the M9 Transport Signal of hnRNP A1 in mRNA Nuclear Export

    Elisa Izaurralde;Artur Jarmolowski;Christina Beisel;Iain W. Mattaj

  • X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

    H. Hu;S. A. Haas;J. Chelly;J. Chelly;H. Van Esch

  • An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus.

    Utz Fischer;Reinhard Lührmann

  • An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs

    Ashwin Chari;Monika M. Golas;Michael Klingenhäger;Nils Neuenkirchen

  • SMN-mediated assembly of RNPs: a complex story.

    Gunter Meister;Christian Eggert;Utz Fischer

  • Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

    Christoph Winkler;Christian Eggert;Dietmar Gradl;Gunter Meister

  • Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex

    Ron A. M. Fouchier;Barbara E. Meyer;James H. M. Simon;Utz Fischer

  • The SARS-CoV-2 RNA-protein interactome in infected human cells.

    Nora Schmidt;Caleb A. Lareau;Hasmik Keshishian;Sabina Ganskih

Frequent Co-Authors

Gunter Meister
Gunter Meister University of Regensburg
Sven Höfling
Sven Höfling University of Würzburg
Reinhard Lührmann
Reinhard Lührmann Max Planck Society
Gideon Dreyfuss
Gideon Dreyfuss University of Pennsylvania
Albert Sickmann
Albert Sickmann Leibniz Institute for Neurobiology
Christoph Winkler
Christoph Winkler National University of Singapore
Michael Sendtner
Michael Sendtner University of Würzburg
Michael H. Malim
Michael H. Malim King's College London
Aarno Palotie
Aarno Palotie University of Helsinki
Malte C. Gather
Malte C. Gather University of St Andrews

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