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D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
13684
World Ranking
15984
National Ranking
6638

Overview

Christian L. Lorson is affiliated with the University of Missouri in the United States and has contributed extensively to research in Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Molecular Biology, Infectious Diseases, Genetics, Cellular and Molecular Neuroscience, and Virology.

Their research topics cover a wide range of areas, including Neurogenetic and Muscular Disorders Research, SARS-CoV-2 and COVID-19 Research, RNA modifications and cancer, RNA Research and Splicing, COVID-19 Clinical Research Studies, Muscle Physiology and Disorders, and HIV Research and Treatment.

Christian L. Lorson has frequently collaborated with several researchers, notably Kamalendra Singh, Saathvik R. Kannan, Siddappa N. Byrareddy, Austin N. Spratt, and Monique A. Lorson. These collaborations have produced research articles and helped expand understanding in their shared fields.

Their recent papers include:

  • Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses (2021, Journal of Autoimmunity)
  • Infectivity of SARS-CoV-2: there Is Something More than D614G? (2020, Journal of Neuroimmune Pharmacology)
  • Mutations in the monkeypox virus replication complex: Potential contributing factors to the 2022 outbreak (2022, Journal of Autoimmunity)
  • Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents (2021, Expert Opinion on Therapeutic Patents)
  • Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants (2021, Computational and Structural Biotechnology Journal)

Christian L. Lorson's research has been published in several venues, with frequent contributions to Human Molecular Genetics, bioRxiv (Cold Spring Harbor Laboratory), Journal of Autoimmunity, JCI Insight, and International Journal of Molecular Sciences. Their work covers an extensive body of literature that informs both clinical and molecular approaches in their fields of study.

Best Publications

  • Induced pluripotent stem cells from a spinal muscular atrophy patient

    Allison D. Ebert;Junying Yu;Ferrill F. Rose;Virginia B. Mattis

  • A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

    Christian L. Lorson;Eric Hahnen;Elliot J. Androphy;Brunhilde Wirth

  • A Single Nucleotide Difference That Alters Splicing Patterns Distinguishes the SMA Gene SMN1 From the Copy Gene SMN2

    Umrao R. Monani;Christian L. Lorson;D. William Parsons;Thomas W. Prior

  • SMN oligomerization defect correlates with spinal muscular atrophy severity.

    Christian L. Lorson;John Strasswimmer;Jun Mei Yao;James D. Baleja

  • An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN.

    Christian L. Lorson;Elliot J. Androphy

  • Htra2-β1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

    Yvonne Hofmann;Christian L. Lorson;Stefan Stamm;Elliot J. Androphy

  • Spinal muscular atrophy: a motor neuron disorder or a multi‐organ disease?

    Monir Shababi;Christian L Lorson;Sabine S Rudnik-Schöneborn

  • Spinal muscular atrophy: mechanisms and therapeutic strategies

    Christian L. Lorson;Hansjorg Rindt;Monir Shababi

  • Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.

    Saathvik R. Kannan;Austin N. Spratt;Alisha R. Cohen;S. Hasan Naqvi

  • Cardiac defects contribute to the pathology of Spinal Muscular Atrophy models

    Monir Shababi;Javad Habibi;Hsiao T. Yang;Spencer M. Vale

  • Survival Motor Neuron Function in Motor Axons Is Independent of Functions Required for Small Nuclear Ribonucleoprotein Biogenesis

    Tessa L. Carrel;Michelle L. McWhorter;Eileen Workman;Honglai Zhang

  • A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy

    Umrao R. Monani;Matthew T. Pastore;Tatiana O. Gavrilina;Sibylle Jablonka

  • SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2β1

    Philip J. Young;Christine J. DiDonato;Diane Hu;Rashmi Kothary

  • A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels

    Elizabeth C. Wolstencroft;Virginia Mattis;Anna A. Bajer;Philip J. Young

  • A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy

    Philip J. Young;Patricia M. Day;Jianhua Zhou;Elliot J. Androphy

  • An in vivo reporter system for measuring increased inclusion of exon 7 in SMN2 mRNA: potential therapy of SMA

    ML Zhang;CL Lorson;EJ Androphy;J Zhou

  • Identification of Survival Motor Neuron as a Transcriptional Activator-Binding Protein

    John Strasswimmer;Christian L. Lorson;David E. Breiding;Jason J. Chen

  • Delivery of therapeutic agents through intracerebroventricular (ICV) and intravenous (IV) injection in mice.

    Jacqueline J. Glascock;Erkan Y. Osman;Tristan H. Coady;Ferrill F. Rose

  • Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy

    Travis D. Baughan;Alexa Dickson;Erkan Y. Osman;Christian L. Lorson

  • The Domain Encoded by Exon 2 of the Survival Motor Neuron Protein Mediates Nucleic Acid Binding

    Christian L. Lorson;Elliot J. Androphy

Frequent Co-Authors

Elliot J. Androphy
Elliot J. Androphy Indiana University
Arthur H.M. Burghes
Arthur H.M. Burghes The Ohio State University
Chien-Ping Ko
Chien-Ping Ko University of Southern California
Gregory D. Cuny
Gregory D. Cuny University of Houston
Rashmi Kothary
Rashmi Kothary Ottawa Hospital
Gary J. Bassell
Gary J. Bassell Emory University
Brunhilde Wirth
Brunhilde Wirth University of Cologne
Angus I. Lamond
Angus I. Lamond University of Dundee
A. Gregory Matera
A. Gregory Matera University of North Carolina at Chapel Hill
Glenn E. Morris
Glenn E. Morris Keele University

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