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Genetics

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122
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Molecular Biology

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122
Citations
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241
National Ranking
144

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • 2018 - Fellow, National Academy of Inventors
  • 2016 - Fellow of the American Academy of Arts and Sciences

Overview

Adrian R. Krainer is affiliated with the Cold Spring Harbor Laboratory in the United States. Their research spans several fields, primarily focused on Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. The scientist's subfields of study include Molecular Biology, Genetics, Surgery, Cellular and Molecular Neuroscience, and Physiology.

Their research topics encompass a range of subjects related to RNA biology and genetic disorders. Key topics are:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Neurogenetic and Muscular Disorders Research
  • Hereditary Neurological Disorders
  • Biomedical Ethics and Regulation
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery

Adrian R. Krainer's recent publications include the following papers:

  • "SnapShot: Splicing Alterations in Cancer" (2020) in Cell
  • "Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model" (2020) in Nucleic Acids Research
  • "Recurrent SRSF2 mutations in MDS affect both splicing and NMD" (2020) in Genes & Development
  • "Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia" (2021) in Nature Communications
  • "Evidence generation and reproducibility in cell and gene therapy research: A call to action" (2021) in Molecular Therapy - Methods & Clinical Development

The scientist has collaborated frequently with several colleagues, including:

  • Krishanu Bhowmick
  • Srinivasan Dasarathy
  • Lopa Mishra
  • Xiyan Xiang
  • Keith A. Crandall

Adrian R. Krainer has published multiple times in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cancer Research, Gastroenterology, and Cell.

Recognition for their work includes membership in the National Academy of Sciences as of 2020, fellowship in the National Academy of Inventors awarded in 2018, and fellowship in the American Academy of Arts and Sciences since 2016.

Best Publications

  • Listening to silence and understanding nonsense: exonic mutations that affect splicing

    Luca Cartegni;Shern L. Chew;Adrian R. Krainer

  • ESEfinder: A web resource to identify exonic splicing enhancers.

    Luca Cartegni;Jinhua Wang;Zhengwei Zhu;Michael Q. Zhang

  • RNA therapeutics: beyond RNA interference and antisense oligonucleotides

    Ryszard Kole;Adrian R. Krainer;Sidney Altman

  • The human splicing code reveals new insights into the genetic determinants of disease

    Hui Y. Xiong;Babak Alipanahi;Babak Alipanahi;Leo J. Lee;Leo J. Lee;Hannes Bretschneider

  • The gene encoding the splicing factor SF2/ASF is a proto-oncogene

    Rotem Karni;Elisa de Stanchina;Scott W Lowe;Rahul Sinha

  • CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

    Ya Guo;Quan Xu;Quan Xu;Daniele Canzio;Jia Shou;Jia Shou

  • Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

    Akila Mayeda;Adrian R. Krainer

  • Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

    Barbara Ruskin;Adrian R. Krainer;Tom Maniatis;Michael R. Green

  • Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1

    Luca Cartegni;Adrian R. Krainer

  • Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

    Ewan Birney;Sanjay Kumar;Adrian R. Krainer

  • Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

    Adrian R. Krainer;Tom Maniatis;Barbara Ruskin;Michael R. Green

  • Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.

    Javier F. Cáceres;Stefan Stamm;David M. Helfman;Adrian R. Krainer

  • Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

    Yimin Hua;Kentaro Sahashi;Frank Rigo;Gene Hung

  • Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

    Yimin Hua;Timothy A. Vickers;Hazeem L. Okunola;C. Frank Bennett

  • Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

    Yimin Hua;Kentaro Sahashi;Gene Hung;Frank Rigo

  • Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins

    Hong Xiang Liu;Michael Zhang;Adrian R. Krainer

  • Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

    Adrian R. Krainer;Akila Mayeda;Diane Kozak;Georgia Binns

  • Pre-mRNA splicing in the new millennium

    Michelle L Hastings;Adrian R Krainer

  • A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

    Javier F. Cáceres;Gavin R. Screaton;Adrian R. Krainer

  • An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers

    Philip J. Smith;Chaolin Zhang;Chaolin Zhang;Jinhua Wang;Shern L. Chew

Frequent Co-Authors

Akila Mayeda
Akila Mayeda Fujita Health University
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
Frank Rigo
Frank Rigo Ionis Pharmaceuticals (United States)
Michael Q. Zhang
Michael Q. Zhang The University of Texas at Dallas
Javier F. Cáceres
Javier F. Cáceres University of Edinburgh
Senthil K. Muthuswamy
Senthil K. Muthuswamy Beth Israel Deaconess Medical Center
Brage S. Andresen
Brage S. Andresen University of Southern Denmark
David L. Spector
David L. Spector Cold Spring Harbor Laboratory
Rui-Ming Xu
Rui-Ming Xu Chinese Academy of Sciences
Katherine W. Klinger
Katherine W. Klinger Sanofi (United States)

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