World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
12997
World Ranking
13728
National Ranking
420

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Rui-Ming Xu is affiliated with the Chinese Academy of Sciences in China and specializes in biochemistry, genetics, and molecular biology. Their research focuses predominantly on molecular biology, with significant contributions spanning related subfields such as cancer research, electrical and electronic engineering, aerospace engineering, and plant science.

The scientist's main topics of work include:

  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • CCD and CMOS Imaging Sensors
  • CRISPR and Genetic Engineering
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • MicroRNA in disease regulation

Rui-Ming Xu has a record of publishing research in venues across multiple scientific journals, including:

  • Science
  • Sensors
  • Nucleic Acids Research
  • Genes & Development
  • bioRxiv (Cold Spring Harbor Laboratory)

Their collaborative work includes frequent co-authors such as Chao-Pei Liu, Qiumei Cao, Mingzhu Wang, Wensi Yang, and Zhiguo Zhang.

Notable recent papers by Rui-Ming Xu include:

  • A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy, 2021, Cell Discovery
  • DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands, 2020, Science Advances
  • Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation, 2020, Cell
  • Structural Basis for pri-miRNA Recognition by Drosha, 2020, Molecular Cell
  • Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation, 2022, Science

In recognition of contributions to science, Rui-Ming Xu was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

    Jinrong Min;Yi Zhang;Rui Ming Xu

  • Cryo-em study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units

    Feng Song;Ping Chen;Dapeng Sun;Mingzhu Wang

  • Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79

    Huck Hui Ng;Rui-Ming Xu;Yi Zhang;Kevin Struhl

  • Recognition of Histone H3 Lysine-4 Methylation by the Double Tudor Domain of JMJD2A

    Ying Huang;Jia Fang;Mark T. Bedford;Yi Zhang

  • Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.

    Jinrong Min;Qin Feng;Zhizhong Li;Yi Zhang

  • Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication

    Junhong Han;Hui Zhou;Bruce Horazdovsky;Kangling Zhang

  • Crystal Structure of a SIR2 Homolog–NAD Complex

    Jinrong Min;Joseph Landry;Rolf Sternglanz;Rui Ming Xu

  • Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA

    Jianzhong Ding;Mariko K. Hayashi;Ying Zhang;Ying Zhang;Lisa Manche

  • The postsynaptic density proteins homer and shank form a polymeric network structure

    Mariko Hayashi;Chunyan Tang;Chiara Verpelli;Radhakrishnan Narayanan

  • A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase.

    James P.J. Chong;Mariko K. Hayashi;Martha N. Simon;Rui Ming Xu

  • The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

    Yan Li;Patrick Trojer;Chong-Feng Xu;Peggie Cheung

  • Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

    Jianzhong Jiang;Ying Zhang;Adrian R. Krainer;Rui-Ming Xu

  • CRYSTAL STRUCTURE OF CASEIN KINASE-1, A PHOSPHATE-DIRECTED PROTEIN KINASE

    Rui-Ming Xu;G. Carmel;R. M. Sweet;J. Kuret

  • Structure of a Bmi-1-Ring1B Polycomb Group Ubiquitin Ligase Complex

    Zhizhong Li;Ru Cao;Ming Wang;Michael P. Myers

  • The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.

    Dong Fang;Haiyun Gan;Jeong Heon Lee;Jing Han

  • A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

    Chuanhe Yu;Haiyun Gan;Albert Serra-Cardona;Lin Zhang

  • Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

    Duanfang Cao;Mingzhu Wang;Xiayang Qiu;Dongxiang Liu

  • Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity.

    Junhong Han;Hui Zhou;Zhizhong Li;Rui Ming Xu

  • hnRNP A1 associates with telomere ends and stimulates telomerase activity.

    Qing Shuo Zhang;Lisa Manche;Rui Ming Xu;Adrian R. Krainer

  • The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation

    Qi Qiao;Yan Li;Zhi Chen;Mingzhu Wang

Frequent Co-Authors

Zhiguo Zhang
Zhiguo Zhang Columbia University
Jinrong Min
Jinrong Min Structural Genomics Consortium
Adrian R. Krainer
Adrian R. Krainer Cold Spring Harbor Laboratory
Xiaodong Cheng
Xiaodong Cheng The University of Texas MD Anderson Cancer Center
Huilin Li
Huilin Li Van Andel Institute
Yi Zhang
Yi Zhang Harvard University
Carlo Sala
Carlo Sala University of Milan
Rolf Sternglanz
Rolf Sternglanz Stony Brook University
Danny Reinberg
Danny Reinberg University of Miami
Zihe Rao
Zihe Rao Tsinghua University

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