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Biology and Biochemistry
China
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
39660
World Ranking
1881
National Ranking
46

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in China Leader Award

Overview

Zihe Rao is affiliated with Tsinghua University in China and has a research focus spanning medicine and biochemistry, genetics, and molecular biology. Their work includes significant contributions to infectious diseases, molecular biology, and epidemiology, with attention to computational theory and mathematics.

The scientist has contributed extensively to research on SARS-CoV-2 and COVID-19, along with viral infections and immunology, and computational drug discovery methods. Other important topics in their work cover viral gastroenteritis research and epidemiology, RNA and protein synthesis mechanisms, tuberculosis research and epidemiology, and bacteriophages and microbial interactions.

Notable recent papers authored or co-authored by Zihe Rao include:

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors, 2020, Nature
  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus, 2020, Science
  • Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, 2020, Science
  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 2020, Cell
  • Structural biology of SARS-CoV-2 and implications for therapeutic development, 2021, Nature Reviews Microbiology

Frequent co-authors in Zihe Rao's publications include:

  • Luke W. Guddat
  • Xiuna Yang
  • Haitao Yang
  • Zhiyong Lou
  • Yao Zhao

The scientist's work is often published in prominent venues such as:

  • Nature Communications
  • Protein & Cell
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell

Zihe Rao's primary fields of study are medicine and biochemistry, genetics, and molecular biology, with particular emphasis on subfields like infectious diseases, molecular biology, epidemiology, cardiology and cardiovascular medicine, and computational theory and mathematics.

Best Publications

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

    Zhenming Jin;Zhenming Jin;Xiaoyu Du;Yechun Xu;Yongqiang Deng

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus.

    Yan Gao;Yan Gao;Liming Yan;Yucen Huang;Fengjiang Liu

  • Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.

    Wenhao Dai;Wenhao Dai;Bing Zhang;Xia Ming Jiang;Haixia Su

  • The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

    Haitao Yang;Maojun Yang;Yi Ding;Yiwei Liu

  • Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II

    Fei Sun;Xia Huo;Yujia Zhai;Aojin Wang

  • Protein production and purification.

    S Gräslund

  • Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

    Haitao Yang;Weiqing Xie;Xiaoyu Xue;Xiaoyu Xue;Kailin Yang;Kailin Yang

  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.

    Quan Wang;Jiqin Wu;Haofeng Wang;Haofeng Wang;Yan Gao

  • Crystal structure of an avian influenza polymerase PA N reveals an endonuclease active site

    Puwei Yuan;Mark Bartlam;Zhiyong Lou;Shoudeng Chen

  • DWARF14 is a non-canonical hormone receptor for strigolactone

    Ruifeng Yao;Zhenhua Ming;Liming Yan;Suhua Li

  • Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

    Yuanyuan Ma;Lijie Wu;Neil Shaw;Yan Gao

  • Architecture of African swine fever virus and implications for viral assembly

    Nan Wang;Dongming Zhao;Jialing Wang;Yangling Zhang

  • A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

    Xiangxi Wang;Wei Peng;Jingshan Ren;Zhongyu Hu

  • Structures of Two Coronavirus Main Proteases : Implications for Substrate Binding and Antiviral Drug Design

    Xiaoyu Xue;Hongwei Yu;Haitao Yang;Haitao Yang;Fei Xue;Fei Xue

  • Structural Basis for the Recognition of Blood Group Trisaccharides by Norovirus

    Sheng Cao;Zhiyong Lou;Ming Tan;Yutao Chen

  • Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.

    Zhenming Jin;Zhenming Jin;Yao Zhao;Yuan Sun;Bing Zhang

  • The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.

    Zihe Rao;P. Handford;M. Mayhew;V. Knott

  • Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

    Zhe Lv;Yong Qiang Deng;Qing Ye;Lei Cao

  • Structural biology of SARS-CoV-2 and implications for therapeutic development.

    Haitao Yang;Zihe Rao

  • Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.

    Zhihui Jia;Liming Yan;Zhilin Ren;Lijie Wu

Frequent Co-Authors

Mark Bartlam
Mark Bartlam Nankai University
Zhiyong Lou
Zhiyong Lou Tsinghua University
George F. Gao
George F. Gao Chinese Center For Disease Control and Prevention
Luke W. Guddat
Luke W. Guddat University of Queensland
David I. Stuart
David I. Stuart University of Oxford
Elizabeth E. Fry
Elizabeth E. Fry University of Oxford
Yanhui Xu
Yanhui Xu Shanghai Medical College of Fudan University
Luet-Lok Wong
Luet-Lok Wong University of Oxford
Yao Zhao
Yao Zhao Beijing Jiaotong University
Qiang Gao
Qiang Gao Beihang University

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