Rolf Hilgenfeld

Overview

Best Publications

• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

  Linlin Zhang;Daizong Lin;Xinyuanyuan Sun;Ute Curth

  3248
  Citations

• Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs

  Kanchan Anand;John Ziebuhr;Parvesh Wadhwani;Jeroen R. Mesters

  2019
  Citations

• The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

  Haitao Yang;Maojun Yang;Yi Ding;Yiwei Liu

  1100
  Citations

• C-h⋯π-interactions in proteins

  Maria Brandl;Manfred S. Weiss;Andreas Jabs;Jürgen Sühnel

  837
  Citations

• Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

  Haitao Yang;Weiqing Xie;Xiaoyu Xue;Xiaoyu Xue;Kailin Yang;Kailin Yang

  773
  Citations

• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

  Jian Lei;Yuri Kusov;Rolf Hilgenfeld

  759
  Citations

• Crystal structure of active elongation factor Tu reveals major domain rearrangements

  Harald Berchtold;Ludmila Reshetnikova;Ludmila Reshetnikova;Christian O. A. Reiser;Norbert K. Schirmer

  751
  Citations

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  Rolf Hilgenfeld

  725
  Citations

• Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.

  Kanchan Anand;Gottfried J. Palm;Jeroen R. Mesters;Stuart G. Siddell

  706
  Citations

• α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

  Linlin Zhang;Daizong Lin;Yuri Kusov;Yong Nian

  564
  Citations

• The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

  Susanne Pfefferle;Julia Schöpf;Manfred Kögl;Caroline C. Friedel;Caroline C. Friedel

  459
  Citations

• Non-proline cis peptide bonds in proteins

  Andreas Jabs;Manfred S Weiss;Rolf Hilgenfeld

  422
  Citations

• Accessory proteins of SARS-CoV and other coronaviruses

  Ding Xiang Liu;To Sing Fung;Kelvin Kian Long Chong;Aditi Shukla

  421
  Citations

• Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

  Michela Bollati;Karin Alvarez;René Assenberg;Cécile Baronti

  416
  Citations

• From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.

  Rolf Hilgenfeld;Malik Peiris

  408
  Citations

• Utility of homology models in the drug discovery process.

  Alexander Hillisch;Luis Felipe Pineda;Rolf Hilgenfeld

  401
  Citations

• Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.

  Jian Lei;Guido Hansen;Christoph Nitsche;Christian D. Klein

  363
  Citations

• Conformational Antagonism between Opposing Active Sites in a Bifunctional RelA/SpoT Homolog Modulates (p)ppGpp Metabolism during the Stringent Response

  Tanis Hogg;Undine Mechold;Horst Malke;Mike Cashel

  360
  Citations

• Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

  Jeroen R Mesters;Cyril Barinka;Weixing Li;Takashi Tsukamoto

  352
  Citations

• X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.

  Sebastian Günther;Patrick Y. A. Reinke;Yaiza Fernández-García;Julia Lieske

  336
  Citations