World's Best Scientists 2026 revealed!
Rolf Hilgenfeld

Rolf Hilgenfeld

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
27257
World Ranking
5477
National Ranking
396

Rolf Hilgenfeld publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Rolf Hilgenfeld sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 340 publications — 84th percentile

84% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Rolf Hilgenfeld D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Rolf Hilgenfeld sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 74 D-Index — 72nd percentile

72% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Rolf Hilgenfeld is affiliated with the University of Lübeck in Germany. Their research primarily spans the fields of Medicine and Computer Science, with a notable focus on Infectious Diseases and Computational Theory and Mathematics.

The core topics in their work include:

  • SARS-CoV-2 and COVID-19 Research
  • Computational Drug Discovery Methods
  • Synthesis and Biological Activity
  • COVID-19 Clinical Research Studies
  • Viral Infections and Immunology Research
  • RNA and Protein Synthesis Mechanisms
  • SARS-CoV-2 Detection and Testing

Hilgenfeld's research has been published in several venues, with a concentration in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Research Square (Research Square)
  • Science
  • Scientific Reports

Frequent coauthors in their publications include:

  • Linlin Zhang
  • Xinyuanyuan Sun
  • Johan Neyts
  • Dirk Jochmans
  • Wioletta Rut

Significant recent papers authored or coauthored by Hilgenfeld include:

  • Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors, 2020, Science
  • Therapeutic strategies for COVID-19: progress and lessons learned, 2023, Nature Reviews Drug Discovery
  • α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment, 2020, Journal of Medicinal Chemistry
  • X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease, 2021, Science
  • SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging, 2020, Nature Chemical Biology

Best Publications

  • Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

    Linlin Zhang;Daizong Lin;Xinyuanyuan Sun;Ute Curth

  • Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs

    Kanchan Anand;John Ziebuhr;Parvesh Wadhwani;Jeroen R. Mesters

  • The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

    Haitao Yang;Maojun Yang;Yi Ding;Yiwei Liu

  • C-h⋯π-interactions in proteins

    Maria Brandl;Manfred S. Weiss;Andreas Jabs;Jürgen Sühnel

  • Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

    Haitao Yang;Weiqing Xie;Xiaoyu Xue;Xiaoyu Xue;Kailin Yang;Kailin Yang

  • Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

    Jian Lei;Yuri Kusov;Rolf Hilgenfeld

  • Crystal structure of active elongation factor Tu reveals major domain rearrangements

    Harald Berchtold;Ludmila Reshetnikova;Ludmila Reshetnikova;Christian O. A. Reiser;Norbert K. Schirmer

  • From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

    Rolf Hilgenfeld

  • Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.

    Kanchan Anand;Gottfried J. Palm;Jeroen R. Mesters;Stuart G. Siddell

  • α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

    Linlin Zhang;Daizong Lin;Yuri Kusov;Yong Nian

  • The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

    Susanne Pfefferle;Julia Schöpf;Manfred Kögl;Caroline C. Friedel;Caroline C. Friedel

  • Non-proline cis peptide bonds in proteins

    Andreas Jabs;Manfred S Weiss;Rolf Hilgenfeld

  • Accessory proteins of SARS-CoV and other coronaviruses

    Ding Xiang Liu;To Sing Fung;Kelvin Kian Long Chong;Aditi Shukla

  • Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

    Michela Bollati;Karin Alvarez;René Assenberg;Cécile Baronti

  • From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.

    Rolf Hilgenfeld;Malik Peiris

  • Utility of homology models in the drug discovery process.

    Alexander Hillisch;Luis Felipe Pineda;Rolf Hilgenfeld

  • Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.

    Jian Lei;Guido Hansen;Christoph Nitsche;Christian D. Klein

  • Conformational Antagonism between Opposing Active Sites in a Bifunctional RelA/SpoT Homolog Modulates (p)ppGpp Metabolism during the Stringent Response

    Tanis Hogg;Undine Mechold;Horst Malke;Mike Cashel

  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

    Jeroen R Mesters;Cyril Barinka;Weixing Li;Takashi Tsukamoto

  • X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.

    Sebastian Günther;Patrick Y. A. Reinke;Yaiza Fernández-García;Julia Lieske

Frequent Co-Authors

Christian Betzel
Christian Betzel Universität Hamburg
Henry N. Chapman
Henry N. Chapman Universität Hamburg
Matthias Rarey
Matthias Rarey Universität Hamburg
Dušan Turk
Dušan Turk Jožef Stefan Institute
Johan Neyts
Johan Neyts Rega Institute for Medical Research
Hualiang Jiang
Hualiang Jiang Chinese Academy of Sciences
John Ziebuhr
John Ziebuhr University of Giessen
Bruno Coutard
Bruno Coutard Aix-Marseille University
Zihe Rao
Zihe Rao Tsinghua University
Bruno Canard
Bruno Canard Aix-Marseille University

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