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D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
7754
World Ranking
18091
National Ranking
27

Overview

Jan Konvalinka is affiliated with the Czech Academy of Sciences in the Czech Republic. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Molecular Biology, Epidemiology, Oncology, Radiology, Nuclear Medicine and Imaging, and Infectious Diseases.

The scientist's work covers several key topics including Influenza Virus Research Studies, RNA and protein synthesis mechanisms, Peptidase Inhibition and Analysis, Monoclonal and Polyclonal Antibodies Research, Bioactive Compounds and Antitumor Agents, Neuropeptides and Animal Physiology, and Protein Structure and Dynamics.

Frequent coauthors collaborating with Jan Konvalinka include:

  • Pavel Majer
  • Pavel Šácha
  • Milan Kožíšek
  • Aleš Machara
  • Kateřina Radilová

Common publication venues for their research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Journal of Medicinal Chemistry
  • Journal of Biological Chemistry
  • ChemMedChem
  • Journal of Medicinal Chemistry

Some recent papers authored or coauthored by Jan Konvalinka include:

  • Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications, 2020, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  • Viral proteases as therapeutic targets, 2022, Molecular Aspects of Medicine
  • Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors, 2020, European Journal of Medicinal Chemistry
  • Predicting Effects of Site-Directed Mutagenesis on Enzyme Kinetics by QM/MM and QM Calculations: A Case of Glutamate Carboxypeptidase II, 2022, The Journal of Physical Chemistry B
  • Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery, 2021, Journal of Medicinal Chemistry

Best Publications

  • From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease

    Petr Cígler;Petr Cígler;Milan Kožíšek;Pavlína Řezáčová;Pavlína Řezáčová;Jíří Brynda

  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

    Jeroen R Mesters;Cyril Barinka;Weixing Li;Takashi Tsukamoto

  • THE SPACER PEPTIDE BETWEEN HUMAN IMMUNODEFICIENCY VIRUS CAPSID AND NUCLEOCAPSID PROTEINS IS ESSENTIAL FOR ORDERED ASSEMBLY AND VIRAL INFECTIVITY

    H G Kräusslich;M Fäcke;A M Heuser;J Konvalinka

  • Sensitive, soluble chromogenic substrates for HIV-1 proteinase.

    A D Richards;L H Phylip;W G Farmerie;P E Scarborough

  • A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism.

    Monique Nijhuis;Noortje M van Maarseveen;Stephane Lastere;Pauline Schipper

  • Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes.

    Pavlína Rezácová;Jana Pokorná;Jana Pokorná;Jirí Brynda;Milan Kozísek;Milan Kozísek

  • An Active-Site Mutation in the Human Immunodeficiency Virus Type 1 Proteinase (PR) Causes Reduced PR Activity and Loss of PR-Mediated Cytotoxicity without Apparent Effect on Virus Maturation and Infectivity

    J Konvalinka;M A Litterst;R Welker;H Kottler

  • Expression of glutamate carboxypeptidase II in human brain.

    Sácha P;Zámecník J;Barinka C;Hlouchová K;Hlouchová K

  • Retroviral proteases and their roles in virion maturation.

    Jan Konvalinka;Hans-Georg Kräusslich;Hans-Georg Kräusslich;Barbara Müller

  • Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity.

    Kvido Strísovský;Jana Jirásková;Adriana Mikulová;Lubomír Rulísek

  • Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.

    Cyril Barinka;Markéta Rinnová;Pavel Šácha;Camilo Rojas

  • Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites.

    Jonathan T. Griffiths;Lowri H. Phylip;Jan Konvalinka;Petr Strop

  • A reliable docking/scoring scheme based on the semiempirical quantum mechanical PM6-DH2 method accurately covering dispersion and H-bonding: HIV-1 protease with 22 ligands.

    Jindrich Fanfrlík;Agnieszka K Bronowska;Jan Rezác;Ondrej Prenosil

  • Current and Novel Inhibitors of HIV Protease.

    Jana Pokorná;Ladislav Machala;Pavlína Řezáčová;Jan Konvalinka

  • Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity

    Cyril Barinka;Pavel Sácha;Pavel Sácha;Jan Sklenár;Jan Sklenár;Petr Man;Petr Man

  • MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

    Lieselotte Vande Walle;Lieselotte Vande Walle;Irma B Stowe;Pavel Sacha;Bettina L Lee

  • Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.

    Milan Kozísek;Petr Cígler;Martin Lepsík;Jindrich Fanfrlík

  • Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

    Cyril Barinka;Miroslava Rovenská;Petra Mlcochová;Klára Hlouchová

  • Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate.

    Kvido Střı́šovský;Kvido Střı́šovský;Jana Jirásková;Jana Jirásková;Cyril Bařinka;Cyril Bařinka;Pavel Majer

  • Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein.

    J Konvalinka;M Löchelt;H Zentgraf;R M Flügel

Frequent Co-Authors

Hans-Georg Kräusslich
Hans-Georg Kräusslich Heidelberg University
Barbara Müller
Barbara Müller University Hospital Heidelberg
Barbara S. Slusher
Barbara S. Slusher Johns Hopkins University School of Medicine
Tomáš Etrych
Tomáš Etrych Czech Academy of Sciences
Pavel Hobza
Pavel Hobza Czech Academy of Sciences
Lubomír Rulíšek
Lubomír Rulíšek Czech Academy of Sciences
Vladimír Král
Vladimír Král University of Chemistry and Technology
John Kay
John Kay Cardiff University
Ben M. Dunn
Ben M. Dunn University of Florida
Maria G. Masucci
Maria G. Masucci Karolinska Institute

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