World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
70
Citations
18509
World Ranking
5822
National Ranking
1787

Biology and Biochemistry

D-Index
70
Citations
18747
World Ranking
6965
National Ranking
3207

Overview

Irene T. Weber is affiliated with Georgia State University in the United States. Their research primarily focuses on medicine and the intersecting fields of immunology and microbiology. Within these domains, their work has a strong emphasis on infectious diseases, virology, and epidemiology, with additional interests in materials chemistry and molecular biology.

The scientist's research centers significantly on HIV/AIDS drug development and treatment, covering related areas such as HIV research and treatment, Pneumocystis jirovecii pneumonia detection and therapy, enzyme structure and function, hepatitis C virus research, amino acid enzymes, and metabolism.

Recent notable papers by Irene T. Weber include:

  • HIV Protease: Historical Perspective and Current Research, 2021, Viruses
  • Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone, 2020, Biochemical and Biophysical Research Communications
  • Evolution of drug resistance in HIV protease, 2020, BMC Bioinformatics
  • Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies, 2020, Journal of Medicinal Chemistry
  • Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance, 2022, Chemical Communications

The scientist has frequently published in the following venues:

  • Biochemical and Biophysical Research Communications
  • Journal of Molecular Graphics and Modelling
  • Viruses
  • BMC Bioinformatics
  • Journal of Medicinal Chemistry

Collaborative research is a significant aspect of their work. Frequent co-authors include:

  • Arun K. Ghosh
  • Johnson Agniswamy
  • Hiroaki Mitsuya
  • Yuan-Fang Wang
  • Robert W. Harrison

The scientist's substantial body of work contributes to understanding drug resistance mechanisms in HIV protease, the design of new HIV-1 protease inhibitors, and the broader field of infectious disease treatment. Their research integrates computational methods, biochemical approaches, and structural biology to investigate enzyme functionality and antiviral drug efficacy.

Best Publications

  • Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

    Alexander Wlodawer;Maria Miller;Mariusz Jaskólski;Bangalore K. Sathyanarayana

  • The structure of the E. coli recA protein monomer and polymer.

    Randall M. Story;Irene T. Weber;Irene T. Weber;Thomas A. Steitz

  • Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 A resolution.

    Irene T. Weber;Thomas A. Steitz

  • Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro

    Yasuhiro Koh;Hirotomo Nakata;Kenji Maeda;Hiromi Ogata

  • Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

    E T Baldwin;I T Weber;R St Charles;J C Xuan

  • Model structure of decorin and implications for collagen fibrillogenesis.

    Irene T. Weber;Robert W. Harrison;Renato V. Iozzo

  • Structure and function of epidermal growth factor-like regions in proteins

    Ettore Appella;Irene T. Weber;Francesco Blasi

  • Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.

    G. Velho;H. Blanché;M. Vaxillaire;C. Bellanné-Chantelot

  • Iron-Based Metal–Organic Frameworks MIL-88B and NH2-MIL-88B: High Quality Microwave Synthesis and Solvent-Induced Lattice “Breathing”

    Mingyan Ma;Angélique Bétard;Irene Weber;Noura Saad Al-Hokbany

  • Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.

    Arun K. Ghosh;Bruno D. Chapsal;Irene T. Weber;Hiroaki Mitsuya

  • Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.

    M Stoffel;P Froguel;J Takeda;H Zouali

  • High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.

    Yunfeng Tie;Peter I. Boross;Peter I. Boross;Yuan-Fang Wang;Laquasha Gaddis

  • Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP.

    D B McKay;I T Weber;T A Steitz

  • Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

    M. Gidh-Jain;J. Takeda;L. Z. Xu;A. J. Lange

  • Molecular modeling of the HIV-1 protease and its substrate binding site.

    Irene T. Weber;Maria Miller;Mariusz Jaskólski;Jonathan Leis

  • Geometric criteria of hydrogen bonds in proteins and identification of "bifurcated" hydrogen bonds.

    Ivan Y. Torshin;Irene T. Weber;Robert W. Harrison

  • Glucokinase Mutations, Insulin Secretion, and Diabetes Mellitus

    G I Bell;S J Pilkis;I T Weber;K S Polonsky

  • HIV-1 Protease: Structural Perspectives on Drug Resistance

    Irene T. Weber;Johnson Agniswamy

  • Crystallographic studies on the activity of glycogen phosphorylase b.

    I. T. Weber;L. N. Johnson;K. S. Wilson;D. G. R. Yeates

  • Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.

    Arun K. Ghosh;David D. Anderson;Irene T. Weber;Hiroaki Mitsuya

  • Model of specific complex between catabolite gene activator protein and B-DNA suggested by electrostatic complementarity.

    Irene T. Weber;Thomas A. Steitz

Frequent Co-Authors

Robert J. Harrison
Robert J. Harrison Murdoch University
Arun K. Ghosh
Arun K. Ghosh Purdue University West Lafayette
Hiroaki Mitsuya
Hiroaki Mitsuya Kumamoto University
John M. Louis
John M. Louis National Institutes of Health
Andrey Kovalevsky
Andrey Kovalevsky Oak Ridge National Laboratory
Jonathan Leis
Jonathan Leis Northwestern University
Stephen Oroszlan
Stephen Oroszlan National Institutes of Health
Terry D. Copeland
Terry D. Copeland National Institutes of Health
Craig E. Cameron
Craig E. Cameron University of North Carolina at Chapel Hill
Thomas A. Steitz
Thomas A. Steitz Yale University

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