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Microbiology

D-Index
58
Citations
10174
World Ranking
3477
National Ranking
1373

Overview

Jonathan Leis is affiliated with Northwestern University in the United States. Their research primarily spans medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. The subfields of their work include epidemiology, virology, immunology, molecular biology, and plant science.

The scientist's recent publications focus largely on viral mechanisms and treatments, especially for herpesvirus and HIV. Some of the notable papers authored by Leis include:

  • Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells, 2021, Journal of Virology
  • Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Selection of functional mutations in the U5-IR stem and loop regions of the Rous sarcoma virus genome, 2020, UNC Libraries

Their work involves collaboration with several frequent co-authors, including Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath, and Michael L. Johnson.

Leis has contributed to research published in several venues with multiple publications across the Journal of Virology, bioRxiv (Cold Spring Harbor Laboratory), and UNC Libraries.

Key research topics associated with Jonathan Leis include:

  • Herpesvirus Infections and Treatments
  • HIV Research and Treatment
  • Cytomegalovirus and herpesvirus research
  • Interferon and immune responses
  • Viral Infectious Diseases and Gene Expression in Insects
  • Plant Virus Research Studies
  • Virus-based gene therapy research

Best Publications

  • Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag

    Lynn VerPlank;Fadila Bouamr;Tracy J. LaGrassa;Beth Agresta

  • Crystal structure of a retroviral protease proves relationship to aspartic protease family.

    Maria Miller;Mariusz Jaskólski;J. K. Mohana Rao;Jonathan Leis

  • The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro.

    Richard A. Katz;George Merkel;Joseph Kulkosky;Jonathan Leis

  • Standardized and simplified nomenclature for proteins common to all retroviruses.

    J Leis;D Baltimore;J M Bishop;J Coffin

  • The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration.

    M Katzman;R A Katz;A M Skalka;J Leis

  • An assembly domain of the Rous sarcoma virus Gag protein required late in budding.

    John W. Wills;Craig E. Cameron;Craig E. Cameron;Carol B. Wilson;Yan Xiang

  • Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells

    Alexandra Kikonyogo;Fadila Bouamr;Marcy L. Vana;Yan Xiang

  • Retroviral DNA Integration

    Patrick Hindmarsh;Jonathan Peter Leis

  • Molecular modeling of the HIV-1 protease and its substrate binding site.

    Irene T. Weber;Maria Miller;Mariusz Jaskólski;Jonathan Leis

  • Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain.

    Yan Xiang;Craig E. Cameron;John W. Wills;Jonathan Leis

  • Characterization of eukaryotic initiation factor 4A, a protein involved in ATP-dependent binding of globin mRNA.

    J. A. Grifo;S. M. Tahara;J. P. Leis;M. A. Morgan

  • Site-Directed Mutagenesis Using Overlap Extension PCR

    Ashok Aiyar;Yan Xiang;Jonathan Leis

  • The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process

    Andrew Pincetic;Zhizhou Kuang;Eun Joo Seo;Jonathan Leis

  • Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcription.

    Ashok Aiyar;David Cobrinik;Zheng Ge;Hsing-Jien Kung

  • Mechanism of Action of Ribonuclease H Isolated from Avian Myeloblastosis Virus and Escherichia coli

    Jonathan P. Leis;Ira Berkower;Jerard Hurwitz

  • Development of drug resistance to HIV-1 protease inhibitors.

    Todd Ridky;Jonathan Leis

  • HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro

    Patrick Hindmarsh;Todd Ridky;Ray Reeves;Mark Andrake

  • A retroviral RNA secondary structure required for efficient initiation of reverse transcription.

    David Cobrinik;Laverne Soskey;Jonathan Leis

  • Modification of the megaprimer method of PCR mutagenesis: improved amplification of the final product.

    Ashok Aiyar;J. Leis

  • Synthetic peptides as substrates and inhibitors of a retroviral protease

    Moshe Kotler;Richard A. Katz;Waleed Danho;Jonathan Leis

Frequent Co-Authors

Craig E. Cameron
Craig E. Cameron University of North Carolina at Chapel Hill
Anna Marie Skalka
Anna Marie Skalka Fox Chase Cancer Center
Richard A. Katz
Richard A. Katz Fox Chase Cancer Center
Alexander Wlodawer
Alexander Wlodawer National Institutes of Health
Xiang-Dong Fu
Xiang-Dong Fu Westlake University
Jerard Hurwitz
Jerard Hurwitz Memorial Sloan Kettering Cancer Center
Mariusz Jaskolski
Mariusz Jaskolski Adam Mickiewicz University in Poznań
Terry D. Copeland
Terry D. Copeland National Institutes of Health
Irene T. Weber
Irene T. Weber Georgia State University
John W. Wills
John W. Wills Pennsylvania State University

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