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Immunology

D-Index
41
Citations
25762
World Ranking
4902
National Ranking
317

Overview

Ludger Klein is affiliated with Ludwig-Maximilians-Universität München in Germany. Their primary research fields are Immunology and Microbiology, with a focus also on Biochemistry, Genetics, and Molecular Biology. Within these broader fields, their work spans subfields including Immunology, Molecular Biology, Epidemiology, Neurology, and Endocrine and Autonomic Systems.

The scientist's research emphasizes several main topics, notably T-cell and B-cell Immunology, Immune Cell Function and Interaction, and Immunotherapy and Immune Responses. Additional topics covered in their work include Biochemical and Molecular Research, Cytomegalovirus and herpesvirus research, Neuroinflammation and Neurodegeneration Mechanisms, and IL-33, ST2, and ILC Pathways.

Ludger Klein has published across several scientific venues. Frequent publication platforms include:

  • Nature Immunology
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zeitschrift für Gastroenterologie
  • Nature Communications

The scientist has collaborated regularly with several coauthors, notably Elisabetta Petrozziello, Simon Grassmann, Sebastian Jarosch, Veit R. Buchholz, and Dirk H. Busch.

Selected recent publications by Ludger Klein include:

  • Antigen presentation for central tolerance induction, 2024, Nature Reviews Immunology
  • B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4, 2024, Nature
  • LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development, 2022, Autophagy
  • Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection, 2020, Nature Immunology
  • Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation, 2020, Nature Communications

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

    Mark S. Anderson;Emily S. Venanzi;Ludger Klein;Zhibin Chen

  • Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).

    Ludger Klein;Bruno Kyewski;Paul M. Allen;Kristin A. Hogquist

  • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

    Jens Derbinski;Antje Schulte;Bruno Kyewski;Ludger Klein;Ludger Klein

  • Origin of regulatory T cells with known specificity for antigen

    Irina Apostolou;Adelaida Sarukhan;Ludger Klein;Harald von Boehmer

  • A CENTRAL ROLE FOR CENTRAL TOLERANCE

    Bruno Kyewski;Ludger Klein

  • Selection of Foxp3 + regulatory T cells specific for self antigen expressed and presented by Aire + medullary thymic epithelial cells

    Katharina Aschenbrenner;Louise M D'Cruz;Louise M D'Cruz;Elisabeth H Vollmann;Elisabeth H Vollmann;Maria Hinterberger

  • Antigen presentation in the thymus for positive selection and central tolerance induction

    Ludger Klein;Maria Hinterberger;Gerald Wirnsberger;Bruno Kyewski

  • Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling.

    Louise M D'Cruz;Ludger Klein

  • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

    Jelena Nedjic;Martin Aichinger;Martin Aichinger;Jan Emmerich;Jan Emmerich;Noboru Mizushima

  • In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro.

    Ludger Klein;Khashayarsha Khazaie;Harald von Boehmer

  • Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

    Ludger Klein;Ludger Klein;Matthias Klugmann;Klaus Armin Nave;Vincent K. Tuohy

  • Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

    J. Christoph Vahl;Christoph Drees;Klaus Heger;Sylvia Heink

  • Autonomous role of medullary thymic epithelial cells in central CD4 + T cell tolerance

    Maria Hinterberger;Martin Aichinger;Olivia Prazeres da Costa;David Voehringer

  • Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

    Tomoyoshi Yamano;Jelena Nedjic;Maria Hinterberger;Madlen Steinert

  • Thymic selection revisited: how essential is it?

    Harald von Boehmer;Iannis Aifantis;Fotini Gounari;Orly Azogui

  • Promiscuous gene expression and central T-cell tolerance: more than meets the eye

    Bruno Kyewski;Jens Derbinski;Jörn Gotter;Ludger Klein

  • Cutting Edge: Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-Deficient Mice

    Marianne Jansson;Vily Panoutsakopoulou;Jessica Baker;Ludger Klein

  • Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

    Ludger Klein;Ellen A. Robey;Chyi-Song Hsieh

  • CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium.

    Ludger Klein;Thomas Klein;Ulrich Rüther;Bruno Kyewski

Frequent Co-Authors

Bruno Kyewski
Bruno Kyewski German Cancer Research Center
Harald von Boehmer
Harald von Boehmer Harvard University
Noboru Mizushima
Noboru Mizushima University of Tokyo
Albert R. La Spada
Albert R. La Spada University of California, Irvine
Tomoyoshi Nozaki
Tomoyoshi Nozaki University of Tokyo
Pascale Cossart
Pascale Cossart Institut Pasteur
Diane Mathis
Diane Mathis Harvard University
Vladimir Benes
Vladimir Benes European Molecular Biology Laboratory
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine
Enza Maria Valente
Enza Maria Valente University of Pavia

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