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Christian Gespach

Christian Gespach

D-Index & Metrics

Medicine

D-Index
75
Citations
16683
World Ranking
19222
National Ranking
644

Overview

Christian Gespach is affiliated with Sorbonne University in France and works primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research spans several subfields, including Molecular Biology, Cancer Research, Biomedical Engineering, Biophysics, and Oncology.

The scientist's work addresses a range of topics, such as 3D Printing in Biomedical Research, Cell Image Analysis Techniques, Cancer Cells and Metastasis, Hippo pathway signaling and YAP/TAZ, Lipid metabolism and biosynthesis, Ubiquitin and proteasome pathways, and Cancer-related molecular mechanisms research.

Among their recent publications are:

  • "MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity" (2021, Nature Methods)
  • "Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells" (2021, Molecular Cancer Research)
  • "CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells" (2020, Oncotarget)

Gespach frequently collaborates with researchers including Arne Peirsman, Eva Blondeel, Tasdiq Ahmed, Jasper Anckaert, and Dominique Audenaert.

Their research has been published in various scientific venues, predominantly:

  • Nature Methods
  • Molecular Cancer Research
  • Oncotarget

Best Publications

  • Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac.

    Olivier De Wever;Quang-Dé Nguyen;Leen Van Hoorde;Marc Bracke

  • Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

    Azeddine Atfi;Si Ham Djelloul;Eric Chastre;Roger Davis

  • Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers.

    Michèle Sabbah;Shahin Emami;Gérard Redeuilh;Sylvia Julien

  • Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

    Laetitia Mazelin;Agnès Bernet;Christelle Bonod-Bidaud;Laurent Pays

  • Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

    Jordan P;Brazåo R;Boavida Mg;Gespach C

  • Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis

    Yasmine Touil;Wassila Igoudjil;Matthieu Corvaisier;Anne-Frederique Dessein

  • Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways

    Samir Attoub;Veerle Noe;Luciano Pirola;Erik Bruyneel

  • Antitumor activity of oxaliplatin in combination with 5-fluorouracil and the thymidylate synthase inhibitor AG337 in human colon, breast and ovarian cancers

    E Raymond;C Buquet-Fagot;S Djelloul;J Mester

  • Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front.

    Olivier De Wever;Patrick Pauwels;Bram De Craene;Michèle Sabbah

  • Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis

    An Hendrix;Dawn Maynard;Patrick Pauwels;Geert Braems

  • Loss of sst2 Somatostatin Receptor Gene Expression in Human Pancreatic and Colorectal Cancer

    Louis Buscail;Nathalie Saint-Laurent;Eric Chastre;Jean-Christophe Vaillant

  • Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes.

    Henri Porte;Eric Chastre;Sophie Prevot;Bernard Nordlinger

  • The role of bile acids in carcinogenesis.

    Philip R. Debruyne;Erik A. Bruyneel;Xuedong Li;Amazia Zimber

  • Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Isolation of the peptide.

    D. Bataille;K. Tatemoto;C. Gespach;H. Jörnvall

  • Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding

    Olivier De Wever;Wendy Westbroek;An Verloes;Nele Bloemen

  • Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa.

    Thierry André;Larissa Kotelevets;Jean-Christophe Vaillant;Anne Marie Coudray

  • Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. Phenotypic and immune characterization of the MODE-K cell line.

    Karine Vidal;Isabelle Grosjean;Jean-Pierre Revillard;Christian Gespach

  • Nuclear bodies and compartments: functional roles and cellular signalling in health and disease.

    Amazia Zimber;Quang-Dé Nguyen;Christian Gespach

  • Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling

    Astrid De Boeck;Patrick Pauwels;Karen Hensen;Jean-Luc Rummens

  • Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum

    D. Bataille;K. Tatemoto;C. Gespach;H. Jörnvall

Frequent Co-Authors

Olivier De Wever
Olivier De Wever Ghent University
Marc Bracke
Marc Bracke Ghent University
Erik Bruyneel
Erik Bruyneel Ghent University
Marc Mareel
Marc Mareel Ghent University Hospital
Erik Bruyneel
Erik Bruyneel Ghent University Hospital
Eric Raymond
Eric Raymond St. Joseph Hospital
Patrick Pauwels
Patrick Pauwels University of Antwerp
Ivan Bièche
Ivan Bièche Institute Curie
Nicole Vaysse
Nicole Vaysse Centre Hospitalier Universitaire de Toulouse

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