His primary scientific interests are in Perforin, Cell biology, Granzyme, MACPF and Cytotoxic T cell. His Perforin study often links to related topics such as Cell membrane. His research in Cell biology intersects with topics in Immune checkpoint, T cell, Regulator and MHC class I.
His Granzyme research includes elements of Pore forming protein, Programmed cell death and Plasma membrane repair. His MACPF research incorporates elements of Protein structure, Granzyme B and Perforin Deficiency. His studies deal with areas such as Exocytosis, Cell and Immunology as well as Cytotoxic T cell.
Ilia Voskoboinik spends much of his time researching Perforin, Cytotoxic T cell, Cell biology, Granzyme and Immunology. Ilia Voskoboinik combines subjects such as Granzyme B, Gene mutation and Lymphocyte with his study of Perforin. His Cytotoxic T cell research is multidisciplinary, relying on both Tumor necrosis factor alpha, Cancer research, Immune system and Effector.
Ilia Voskoboinik focuses mostly in the field of Cell biology, narrowing it down to matters related to Biochemistry and, in some cases, Copper deficiency. His Granzyme research also works with subjects such as
Ilia Voskoboinik mostly deals with Perforin, Cytotoxic T cell, Cancer research, Membrane and Cell biology. To a larger extent, Ilia Voskoboinik studies Immunology with the aim of understanding Perforin. He works in the field of Cytotoxic T cell, namely Granzyme.
As a member of one scientific family, Ilia Voskoboinik mostly works in the field of Granzyme, focusing on Proteases and, on occasion, Cell culture, Programmed cell death, Molecular biology and Granzyme B. His Cancer research research incorporates themes from Inhibitor of apoptosis, Antigen and Effector. In his study, Plasma membrane organization is inextricably linked to Immune system, which falls within the broad field of Cell biology.
His main research concerns Cytotoxic T cell, Perforin, Cancer research, Cell biology and Granzyme. His Cytotoxic T cell research incorporates elements of Chimeric antigen receptor and Immunotherapy. Ilia Voskoboinik connects Perforin with DNA vaccination in his research.
The concepts of his Cancer research study are interwoven with issues in Tumor necrosis factor alpha, Inhibitor of apoptosis, T cell, Apoptosis and Antigen. His Cell biology research integrates issues from Natural killer T cell, Plasma membrane organization and Immune system.
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Perforin and granzymes: function, dysfunction and human pathology
Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2015)
Perforin-mediated target-cell death and immune homeostasis
Ilia Voskoboinik;Ilia Voskoboinik;Mark J. Smyth;Mark J. Smyth;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2006)
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
Marian L Burr;Marian L Burr;Marian L Burr;Christina E Sparbier;Yih-Chih Chan;James C Williamson.
The structural basis for membrane binding and pore formation by lymphocyte perforin
Ruby H P Law;Natalya Lukoyanova;Ilia Voskoboinik;Ilia Voskoboinik;Tom T Caradoc-Davies.
A Common Fold Mediates Vertebrate Defense and Bacterial Attack
Carlos J. Rosado;Ashley M. Buckle;Ruby H. P. Law;Rebecca E. Butcher;Rebecca E. Butcher.
The MACPF/CDC family of pore-forming toxins.
Carlos Joaquim Rosado;Stephanie Kondos;Tara Elaina Bull;Michael Kuiper.
Cellular Microbiology (2008)
Molecular mechanisms of copper homeostasis.
J. Camakaris;I. Voskoboinik;J.F. Mercer.
Biochemical and Biophysical Research Communications (1999)
Perforin: structure, function, and role in human immunopathology
Ilia Voskoboinik;Michelle Anne Dunstone;Katherine Baran;James Whisstock.
Immunological Reviews (2010)
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
Jamie Lopez;Jamie Lopez;Olivia Susanto;Misty Jenkins;Misty Jenkins;Natalya Lukoyanova.
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.
Ilia Voskoboinik;Marie-Claude Thia;Jamie Fletcher;Annette Ciccone.
Journal of Biological Chemistry (2005)
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