D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 7,960 101 World Ranking 16654 National Ranking 474

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Immune system

His primary scientific interests are in Perforin, Cell biology, Granzyme, MACPF and Cytotoxic T cell. His Perforin study often links to related topics such as Cell membrane. His research in Cell biology intersects with topics in Immune checkpoint, T cell, Regulator and MHC class I.

His Granzyme research includes elements of Pore forming protein, Programmed cell death and Plasma membrane repair. His MACPF research incorporates elements of Protein structure, Granzyme B and Perforin Deficiency. His studies deal with areas such as Exocytosis, Cell and Immunology as well as Cytotoxic T cell.

His most cited work include:

  • Perforin-mediated target-cell death and immune homeostasis (421 citations)
  • Perforin-mediated target-cell death and immune homeostasis (421 citations)
  • Perforin and granzymes: function, dysfunction and human pathology (399 citations)

What are the main themes of his work throughout his whole career to date?

Ilia Voskoboinik spends much of his time researching Perforin, Cytotoxic T cell, Cell biology, Granzyme and Immunology. Ilia Voskoboinik combines subjects such as Granzyme B, Gene mutation and Lymphocyte with his study of Perforin. His Cytotoxic T cell research is multidisciplinary, relying on both Tumor necrosis factor alpha, Cancer research, Immune system and Effector.

Ilia Voskoboinik focuses mostly in the field of Cell biology, narrowing it down to matters related to Biochemistry and, in some cases, Copper deficiency. His Granzyme research also works with subjects such as

  • Perforin Deficiency that connect with fields like Immune dysregulation,
  • Programmed cell death that intertwine with fields like Cell. His research investigates the connection between Immunology and topics such as Hemophagocytic lymphohistiocytosis that intersect with issues in Leukemia.

He most often published in these fields:

  • Perforin (108.76%)
  • Cytotoxic T cell (81.75%)
  • Cell biology (70.80%)

What were the highlights of his more recent work (between 2018-2021)?

  • Perforin (108.76%)
  • Cytotoxic T cell (81.75%)
  • Cancer research (16.79%)

In recent papers he was focusing on the following fields of study:

Ilia Voskoboinik mostly deals with Perforin, Cytotoxic T cell, Cancer research, Membrane and Cell biology. To a larger extent, Ilia Voskoboinik studies Immunology with the aim of understanding Perforin. He works in the field of Cytotoxic T cell, namely Granzyme.

As a member of one scientific family, Ilia Voskoboinik mostly works in the field of Granzyme, focusing on Proteases and, on occasion, Cell culture, Programmed cell death, Molecular biology and Granzyme B. His Cancer research research incorporates themes from Inhibitor of apoptosis, Antigen and Effector. In his study, Plasma membrane organization is inextricably linked to Immune system, which falls within the broad field of Cell biology.

Between 2018 and 2021, his most popular works were:

  • The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 (27 citations)
  • The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 (27 citations)
  • Antagonism of IAPs Enhances CAR T-cell Efficacy. (20 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Immune system

His main research concerns Cytotoxic T cell, Perforin, Cancer research, Cell biology and Granzyme. His Cytotoxic T cell research incorporates elements of Chimeric antigen receptor and Immunotherapy. Ilia Voskoboinik connects Perforin with DNA vaccination in his research.

The concepts of his Cancer research study are interwoven with issues in Tumor necrosis factor alpha, Inhibitor of apoptosis, T cell, Apoptosis and Antigen. His Cell biology research integrates issues from Natural killer T cell, Plasma membrane organization and Immune system.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2015)

808 Citations

Perforin-mediated target-cell death and immune homeostasis

Ilia Voskoboinik;Ilia Voskoboinik;Mark J. Smyth;Mark J. Smyth;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2006)

645 Citations

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr;Marian L Burr;Marian L Burr;Christina E Sparbier;Yih-Chih Chan;James C Williamson.
Nature (2017)

503 Citations

The structural basis for membrane binding and pore formation by lymphocyte perforin

Ruby H P Law;Natalya Lukoyanova;Ilia Voskoboinik;Ilia Voskoboinik;Tom T Caradoc-Davies.
Nature (2010)

412 Citations

A Common Fold Mediates Vertebrate Defense and Bacterial Attack

Carlos J. Rosado;Ashley M. Buckle;Ruby H. P. Law;Rebecca E. Butcher;Rebecca E. Butcher.
Science (2007)

314 Citations

The MACPF/CDC family of pore-forming toxins.

Carlos Joaquim Rosado;Stephanie Kondos;Tara Elaina Bull;Michael Kuiper.
Cellular Microbiology (2008)

311 Citations

Molecular mechanisms of copper homeostasis.

J. Camakaris;I. Voskoboinik;J.F. Mercer.
Biochemical and Biophysical Research Communications (1999)

281 Citations

Perforin: structure, function, and role in human immunopathology

Ilia Voskoboinik;Michelle Anne Dunstone;Katherine Baran;James Whisstock.
Immunological Reviews (2010)

254 Citations

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Jamie Lopez;Jamie Lopez;Olivia Susanto;Misty Jenkins;Misty Jenkins;Natalya Lukoyanova.
Blood (2013)

249 Citations

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

Ilia Voskoboinik;Marie-Claude Thia;Jamie Fletcher;Annette Ciccone.
Journal of Biological Chemistry (2005)

199 Citations

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