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James C. Whisstock

James C. Whisstock

D-Index & Metrics

Molecular Biology

D-Index
89
Citations
25968
World Ranking
762
National Ranking
21

Research.com Recognitions

  • 2018 - Australian Laureate Fellow
  • 2010 - Gottschalk Medal, Australian Academy of Science

Overview

James C. Whisstock is a researcher affiliated with Monash University in Australia. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a substantial contribution to Medicine. Within these broader fields, their focus areas include Molecular Biology, Immunology, Cancer Research, Structural Biology, and Cell Biology.

The scientist's research covers several main topics, including:

  • Protease and Inhibitor Mechanisms
  • Advanced Electron Microscopy Techniques and Applications
  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research
  • Machine Learning in Bioinformatics
  • Electron and X-Ray Spectroscopy Techniques
  • Advanced Proteomics Techniques and Applications

James C. Whisstock has published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ChemMedChem
  • Journal of Structural Biology
  • Nature Communications
  • Nature Structural & Molecular Biology

Frequent co-authors in their work include Ruby H. P. Law, Charles Bayly-Jones, Laura D'Andrea, Hariprasad Venugopal, and Alex de Marco.

Selected recent papers authored or co-authored by James C. Whisstock include:

  • Automated cryo-lamella preparation for high-throughput in-situ structural biology, 2020, Journal of Structural Biology
  • Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities, 2020, Nature Communications
  • The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins: EVOLUTION, MECHANISM OF INHIBITION, NOVEL FUNCTIONS, AND A REVISED NOMENCLATURE, 2021, UNC Libraries
  • The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1, 2021, Nature Structural & Molecular Biology
  • Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector, 2020, Frontiers in Immunology

James C. Whisstock has been recognized with awards including the Australian Laureate Fellow in 2018 and the Gottschalk Medal from the Australian Academy of Science in 2010.

Best Publications

  • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

    Gary A. Silverman;Phillip I. Bird;Robin W. Carrell;Frank C. Church

  • Perforin and granzymes: function, dysfunction and human pathology

    Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani

  • Prediction of protein function from protein sequence and structure.

    James C. Whisstock;Arthur M. Lesk

  • An overview of the serpin superfamily

    Ruby H P Law;Qingwei Zhang;Sheena McGowan;Ashley Maurice Buckle

  • Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

    James A. Irving;Robert N. Pike;Arthur M. Lesk;James C. Whisstock

  • The structural basis for membrane binding and pore formation by lymphocyte perforin

    Ruby H P Law;Natalya Lukoyanova;Ilia Voskoboinik;Ilia Voskoboinik;Tom T Caradoc-Davies

  • IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

    Claudia A Nold-Petry;Camden Y Lo;Ina Rudloff;Kirstin D Elgass

  • A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

    Lars Kjer-Nielsen;Craig S. Clements;Anthony W. Purcell;Andrew G. Brooks

  • A Common Fold Mediates Vertebrate Defense and Bacterial Attack

    Carlos J. Rosado;Ashley M. Buckle;Ruby H. P. Law;Rebecca E. Butcher;Rebecca E. Butcher

  • The MACPF/CDC family of pore-forming toxins.

    Carlos Joaquim Rosado;Stephanie Kondos;Tara Elaina Bull;Michael Kuiper

  • T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.

    Fleur Elizabeth Tynan;Scott R Burrows;Ashley Maurice Buckle;Craig Steven Clements

  • Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

    Jamie Lopez;Jamie Lopez;Olivia Susanto;Misty Jenkins;Misty Jenkins;Natalya Lukoyanova

  • Conservation within the myosin motor domain: implications for structure and function.

    M Jamie Tv Cope;James Whisstock;Ivan Rayment;John Kendrick-Jones

  • Glycoprotein Ib-IX-V.

    Robert Keith Andrews;Elizabeth Ellen Gardiner;Yang Shen;James C Whisstock

  • GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

    G Fenalti;R.H.P Law;A.M Buckle;C Langendorf

  • Perforin: structure, function, and role in human immunopathology

    Ilia Voskoboinik;Michelle Anne Dunstone;Katherine Baran;James Whisstock

  • The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

    Hayley J Newton;Jaclyn S Pearson;Luminita Badea;Michelle Kelly

  • The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site

    Richard Skinner;Jan Pieter Abrahams;James C. Whisstock;Arthur M. Lesk

  • Functional insights from the distribution and role of homopeptide repeat-containing proteins.

    Noel Garry Faux;Stephen Paul Bottomley;Arthur M Lesk;James Alexander Irving

  • Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions

    C A van der Weyden;S A Pileri;S A Pileri;A L Feldman;J Whisstock

Frequent Co-Authors

Robert N. Pike
Robert N. Pike La Trobe University
Stephen P. Bottomley
Stephen P. Bottomley Monash University
Ashley M. Buckle
Ashley M. Buckle Monash University
Phillip I. Bird
Phillip I. Bird Monash University
Joseph A. Trapani
Joseph A. Trapani Peter MacCallum Cancer Centre
Ilia Voskoboinik
Ilia Voskoboinik Peter MacCallum Cancer Centre
Arthur M. Lesk
Arthur M. Lesk Pennsylvania State University
Jamie Rossjohn
Jamie Rossjohn Monash University
Jiangning Song
Jiangning Song Monash University
Julian I. Rood
Julian I. Rood Monash University

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