2018 - Australian Laureate Fellow
2010 - Gottschalk Medal, Australian Academy of Science
James C. Whisstock mainly investigates Biochemistry, Protein structure, Cell biology, Perforin and Serpin. His Biochemistry research incorporates elements of Biophysics and In vivo. James C. Whisstock has researched Protein structure in several fields, including Theoretical computer science, Protein secondary structure, Peptide sequence, Conformational change and Reactive center.
The various areas that James C. Whisstock examines in his Cell biology study include Inflammation, Receptor, Immune system and Platelet. His research on Perforin also deals with topics like
His primary areas of study are Biochemistry, Cell biology, Serpin, Protein structure and Perforin. His study in Protease, Enzyme, Proteases, Peptide sequence and Binding site falls within the category of Biochemistry. His studies in Enzyme integrate themes in fields like Amino acid, Plasmodium falciparum and Aminopeptidase.
He combines subjects such as Drosophila melanogaster, Drosophila Protein, Secretion and Cell membrane with his study of Cell biology. His research integrates issues of Crystallography, Molecular biology and Biophysics, Conformational change in his study of Serpin. His Complement membrane attack complex research extends to Perforin, which is thematically connected.
His primary scientific interests are in Cell biology, Perforin, Complement membrane attack complex, MACPF and Plasmin. His biological study spans a wide range of topics, including Drosophila melanogaster and Drosophila Protein. Cytotoxic T cell and Biochemistry are the subject areas of his Perforin study.
His work carried out in the field of Biochemistry brings together such families of science as Pathogen and Myeloma protein. James C. Whisstock has included themes like Biophysics, Macrophage and Transmembrane protein in his Complement membrane attack complex study. His MACPF research includes themes of Pore forming protein and Cholesterol-dependent cytolysin.
His primary areas of investigation include Perforin, Cell biology, MACPF, Genetics and Biophysics. As part of his research on Perforin, studies on Cytotoxic T cell and Biochemistry are part of the effort. Many of his research projects under Cytotoxic T cell are closely connected to Electron microscope with Electron microscope, tying the diverse disciplines of science together.
His Cell biology research is multidisciplinary, incorporating perspectives in Mutation, Cell, Liver infection and Hepatocyte growth factor. His MACPF research focuses on subjects like Granzyme B, which are linked to Natural killer cell, Secretion, Degranulation and Endoplasmic reticulum. His Biophysics study integrates concerns from other disciplines, such as Nanotechnology, Protein domain, Membrane, Membrane protein and Complement membrane attack complex.
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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
Gary A. Silverman;Phillip I. Bird;Robin W. Carrell;Frank C. Church.
Journal of Biological Chemistry (2001)
Prediction of protein function from protein sequence and structure.
James C. Whisstock;Arthur M. Lesk.
Quarterly Reviews of Biophysics (2003)
Perforin and granzymes: function, dysfunction and human pathology
Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2015)
MUSTANG: a multiple structural alignment algorithm.
Arun Siddhartha Konagurthu;James C Whisstock;Peter J Stuckey;Arthur M Lesk.
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
James A. Irving;Robert N. Pike;Arthur M. Lesk;James C. Whisstock.
Genome Research (2000)
An overview of the serpin superfamily
Ruby H P Law;Qingwei Zhang;Sheena McGowan;Ashley Maurice Buckle.
Genome Biology (2006)
The structural basis for membrane binding and pore formation by lymphocyte perforin
Ruby H P Law;Natalya Lukoyanova;Ilia Voskoboinik;Ilia Voskoboinik;Tom T Caradoc-Davies.
A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity
Lars Kjer-Nielsen;Craig S. Clements;Anthony W. Purcell;Andrew G. Brooks.
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.
Adrienne W Paton;Travis Clarke Beddoe;Cheleste M Thorpe;James Whisstock.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Claudia A Nold-Petry;Camden Y Lo;Ina Rudloff;Kirstin D Elgass.
Nature Immunology (2015)
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