David A. Lomas mainly investigates COPD, Internal medicine, Biochemistry, Protein structure and Familial encephalopathy with neuroserpin inclusion bodies. His biological study spans a wide range of topics, including Exacerbation, Immunology, Biomarker, Prospective cohort study and Surrogate endpoint. His research integrates issues of Physical therapy and Pathology in his study of Internal medicine.
The various areas that David A. Lomas examines in his Biochemistry study include Molecular biology, Toxicity and Alpha 1-antitrypsin deficiency. His Protein structure research includes elements of Drug design, Crystallography, Protein folding, Stereochemistry and Reactive center. His Familial encephalopathy with neuroserpin inclusion bodies research is multidisciplinary, incorporating elements of Biophysics and Neuroserpin.
David A. Lomas spends much of his time researching COPD, Internal medicine, Immunology, Serpin and Biochemistry. His work deals with themes such as Genome-wide association study, Single-nucleotide polymorphism, Pulmonary disease, Exacerbation and Physical therapy, which intersect with COPD. His Internal medicine research is multidisciplinary, relying on both Gastroenterology and Pathology.
His research in Serpin intersects with topics in Serine, Neuroserpin, Familial encephalopathy with neuroserpin inclusion bodies, Point mutation and Protein structure. David A. Lomas works mostly in the field of Neuroserpin, limiting it down to concerns involving Endoplasmic reticulum and, occasionally, Mutant and Intracellular. As a part of the same scientific family, David A. Lomas mostly works in the field of Alpha 1-antitrypsin deficiency, focusing on Molecular biology and, on occasion, Secretion.
His primary areas of investigation include COPD, Internal medicine, Fluticasone propionate, Vilanterol and Exacerbation. His studies deal with areas such as Genome-wide association study, Immunology, Lung, Genetic association and Treatment response as well as COPD. His Immunology research includes themes of Phenotype and Pulmonary fibrosis.
His Internal medicine study frequently links to other fields, such as Gastroenterology. His studies in Fluticasone propionate integrate themes in fields like Clinical trial and Hazard ratio. He has researched Exacerbation in several fields, including Dual therapy, Disease and Lung function.
His scientific interests lie mostly in COPD, Internal medicine, Fluticasone propionate, Vilanterol and Exacerbation. The study incorporates disciplines such as Genome-wide association study, Inflammation, Immunology, Genetic association and Physical therapy in addition to COPD. His Immunology study combines topics from a wide range of disciplines, such as Population study, Lung, Allele, Haplotype and Risk factor.
David A. Lomas works mostly in the field of Genetic association, limiting it down to topics relating to Genetic epidemiology and, in certain cases, Cohort and Chromosome 19, as a part of the same area of interest. The Internal medicine study combines topics in areas such as Gastroenterology and Single-nucleotide polymorphism. His Fluticasone propionate research incorporates elements of Inhaler and Budesonide, Formoterol.
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Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
John R. Hurst;Jørgen Vestbo;Jørgen Vestbo;Antonio Anzueto;Nicholas Locantore.
The New England Journal of Medicine (2010)
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
Gary A. Silverman;Phillip I. Bird;Robin W. Carrell;Frank C. Church.
Journal of Biological Chemistry (2001)
Characterisation of COPD heterogeneity in the ECLIPSE cohort
Àlvar Agustí;Peter Ma Calverley;Bartolome R Celli;Harvey O Coxson.
Respiratory Research (2010)
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
D A Lomas;D L Evans;J T Finch;R W Carrell.
Nature (1992)
Changes in forced expiratory volume in 1 second over time in copd
Jørgen Vestbo;Jørgen Vestbo;Lisa D. Edwards;Paul D. Scanlon;Julie C. Yates.
The New England Journal of Medicine (2011)
Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Identification of Biologic Clusters and Their Biomarkers
Mona Bafadhel;Susan McKenna;Sarah Terry;Vijay Mistry.
American Journal of Respiratory and Critical Care Medicine (2011)
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.
Alvar Agustí;Lisa D. Edwards;Stephen I. Rennard;William MacNee.
PLOS ONE (2012)
A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
Sreekumar G. Pillai;Dongliang Ge;Guohua Zhu;Xiangyang Kong.
PLOS Genetics (2009)
Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE).
J Vestbo;W Anderson;H O Coxson;C Crim.
European Respiratory Journal (2008)
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
Kosuke Yusa;S. Tamir Rashid;Helene Strick-Marchand;Helene Strick-Marchand;Ignacio Varela.
Nature (2011)
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