D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 85 Citations 29,472 273 World Ranking 7448 National Ranking 686

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Enzyme

David A. Lomas mainly investigates COPD, Internal medicine, Biochemistry, Protein structure and Familial encephalopathy with neuroserpin inclusion bodies. His biological study spans a wide range of topics, including Exacerbation, Immunology, Biomarker, Prospective cohort study and Surrogate endpoint. His research integrates issues of Physical therapy and Pathology in his study of Internal medicine.

The various areas that David A. Lomas examines in his Biochemistry study include Molecular biology, Toxicity and Alpha 1-antitrypsin deficiency. His Protein structure research includes elements of Drug design, Crystallography, Protein folding, Stereochemistry and Reactive center. His Familial encephalopathy with neuroserpin inclusion bodies research is multidisciplinary, incorporating elements of Biophysics and Neuroserpin.

His most cited work include:

  • Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease (1876 citations)
  • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature (1046 citations)
  • The mechanism of Z alpha 1-antitrypsin accumulation in the liver. (881 citations)

What are the main themes of his work throughout his whole career to date?

David A. Lomas spends much of his time researching COPD, Internal medicine, Immunology, Serpin and Biochemistry. His work deals with themes such as Genome-wide association study, Single-nucleotide polymorphism, Pulmonary disease, Exacerbation and Physical therapy, which intersect with COPD. His Internal medicine research is multidisciplinary, relying on both Gastroenterology and Pathology.

His research in Serpin intersects with topics in Serine, Neuroserpin, Familial encephalopathy with neuroserpin inclusion bodies, Point mutation and Protein structure. David A. Lomas works mostly in the field of Neuroserpin, limiting it down to concerns involving Endoplasmic reticulum and, occasionally, Mutant and Intracellular. As a part of the same scientific family, David A. Lomas mostly works in the field of Alpha 1-antitrypsin deficiency, focusing on Molecular biology and, on occasion, Secretion.

He most often published in these fields:

  • COPD (37.94%)
  • Internal medicine (30.04%)
  • Immunology (19.76%)

What were the highlights of his more recent work (between 2016-2021)?

  • COPD (37.94%)
  • Internal medicine (30.04%)
  • Fluticasone propionate (7.31%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include COPD, Internal medicine, Fluticasone propionate, Vilanterol and Exacerbation. His studies deal with areas such as Genome-wide association study, Immunology, Lung, Genetic association and Treatment response as well as COPD. His Immunology research includes themes of Phenotype and Pulmonary fibrosis.

His Internal medicine study frequently links to other fields, such as Gastroenterology. His studies in Fluticasone propionate integrate themes in fields like Clinical trial and Hazard ratio. He has researched Exacerbation in several fields, including Dual therapy, Disease and Lung function.

Between 2016 and 2021, his most popular works were:

  • Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD (398 citations)
  • Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis (170 citations)
  • FULFIL Trial: Once-Daily Triple Therapy for Patients with Chronic Obstructive Pulmonary Disease (163 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Enzyme

His scientific interests lie mostly in COPD, Internal medicine, Fluticasone propionate, Vilanterol and Exacerbation. The study incorporates disciplines such as Genome-wide association study, Inflammation, Immunology, Genetic association and Physical therapy in addition to COPD. His Immunology study combines topics from a wide range of disciplines, such as Population study, Lung, Allele, Haplotype and Risk factor.

David A. Lomas works mostly in the field of Genetic association, limiting it down to topics relating to Genetic epidemiology and, in certain cases, Cohort and Chromosome 19, as a part of the same area of interest. The Internal medicine study combines topics in areas such as Gastroenterology and Single-nucleotide polymorphism. His Fluticasone propionate research incorporates elements of Inhaler and Budesonide, Formoterol.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease

John R. Hurst;Jørgen Vestbo;Jørgen Vestbo;Antonio Anzueto;Nicholas Locantore.
The New England Journal of Medicine (2010)

2885 Citations

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

Gary A. Silverman;Phillip I. Bird;Robin W. Carrell;Frank C. Church.
Journal of Biological Chemistry (2001)

1464 Citations

Characterisation of COPD heterogeneity in the ECLIPSE cohort

Àlvar Agustí;Peter Ma Calverley;Bartolome R Celli;Harvey O Coxson.
Respiratory Research (2010)

1307 Citations

The mechanism of Z alpha 1-antitrypsin accumulation in the liver.

D A Lomas;D L Evans;J T Finch;R W Carrell.
Nature (1992)

1125 Citations

Changes in forced expiratory volume in 1 second over time in copd

Jørgen Vestbo;Jørgen Vestbo;Lisa D. Edwards;Paul D. Scanlon;Julie C. Yates.
The New England Journal of Medicine (2011)

933 Citations

Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Identification of Biologic Clusters and Their Biomarkers

Mona Bafadhel;Susan McKenna;Sarah Terry;Vijay Mistry.
American Journal of Respiratory and Critical Care Medicine (2011)

905 Citations

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.

Alvar Agustí;Lisa D. Edwards;Stephen I. Rennard;William MacNee.
PLOS ONE (2012)

800 Citations

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

Sreekumar G. Pillai;Dongliang Ge;Guohua Zhu;Xiangyang Kong.
PLOS Genetics (2009)

737 Citations

Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE).

J Vestbo;W Anderson;H O Coxson;C Crim.
European Respiratory Journal (2008)

680 Citations

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

Kosuke Yusa;S. Tamir Rashid;Helene Strick-Marchand;Helene Strick-Marchand;Ignacio Varela.
Nature (2011)

667 Citations

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