2026 Robert N. Pike: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	70	7078	6527	179	177	221	15917

Research.com Recognitions

2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Robert N. Pike is affiliated with La Trobe University in Australia. Their research spans several fields related to medicine, biochemistry, genetics, molecular biology, immunology, and microbiology, with a focus on both broad and specialized topics within these disciplines.

The primary fields of study associated with Robert N. Pike include:

Medicine
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology

Within these areas, their subfields of study concentrate on:

Immunology
Hematology
Genetics
Periodontics
Physiology

Key topics addressed in their research encompass:

Blood Coagulation and Thrombosis Mechanisms
Complement system in diseases
Oral microbiology and periodontitis research
Adenosine and Purinergic Signaling
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Protease and Inhibitor Mechanisms
Escherichia coli research studies

Robert N. Pike's recent publications cover a range of topics and demonstrate collaboration with various co-authors. Their papers include:

"Mapping the binding site of C1-inhibitor for polyanion cofactors," 2020, Molecular Immunology
"Effect of a protease-activated receptor-2 antagonist (GB88) on inflammation-related loss of alveolar bone in periodontal disease," 2023, Journal of Periodontal Research
"The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity," 2025, Gut Microbes
"Molecular Interactions Required for Activation of Complement Component C2 Include Exosites Located on the Serine Protease Domain of C1s and Mannose-Binding Lectin Associated Protease-2," 2024, The Journal of Immunology

Frequent co-authors in these projects have been:

Lakshmi C. Wijeyewickrema
Lilian Hor
Jing Pan
Nidhish Francis
Reza Sanaei

The venues where Robert N. Pike's work has been published include:

Journal of Periodontal Research
Molecular Immunology
Gut Microbes
The Journal of Immunology

Best Publications

The anticoagulant activation of antithrombin by heparin.

Lei Jin;Jan Pieter Abrahams;Jan Pieter Abrahams;Richard Skinner;Maurice Petitou

892
Citations
An overview of the serpin superfamily

Ruby H P Law;Qingwei Zhang;Sheena McGowan;Ashley Maurice Buckle

825
Citations
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

James A. Irving;Robert N. Pike;Arthur M. Lesk;James C. Whisstock

755
Citations
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Stephen Scally;Jan Petersen;Soi Cheng Cheng Law;Nadine Lee Dudek

494
Citations
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins.

R. Pike;W. McGraw;J. Potempa;J. Travis

415
Citations
Corruption of innate immunity by bacterial proteases.

Jan Potempa;Robert Neil Pike

343
Citations
PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites

Jiangning Song;Jiangning Song;Hao Tan;Andrew J. Perry;Tatsuya Akutsu

335
Citations
A Common Fold Mediates Vertebrate Defense and Bacterial Attack

Carlos J. Rosado;Ashley M. Buckle;Ruby H. P. Law;Rebecca E. Butcher;Rebecca E. Butcher

335
Citations
The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain.

J Potempa;R Pike;J Travis

322
Citations
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

G Fenalti;R.H.P Law;A.M Buckle;C Langendorf

288
Citations
Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity.

Afrodite Lourbakos;Yu Ping Yuan;Alison L. Jenkins;James Travis

283
Citations
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion

Afrodite Lourbakos;Jan Potempa;James Travis;Michael R. D'Andrea

276
Citations
Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis.

J. Travis;R. Pike;Takahisa Imamura;J. Potempa

245
Citations
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.

Takahisa Imamura;Robert N. Pike;Jan Potempa;James Travis

243
Citations
The X-ray crystal structure of full-length human plasminogen

Ruby H.P. Law;Tom Caradoc-Davies;Nathan Cowieson;Anita J. Horvath

232
Citations
Molecular Cloning and Structural Characterization of the Arg-gingipain Proteinase of Porphyromonas gingivalis: BIOSYNTHESIS AS A PROTEINASE-ADHESIN POLYPROTEIN

Nadine Pavloff;Jan Potempa;Robert N. Pike;Vaclav Prochazka

226
Citations
Antithrombin: in control of coagulation.

Noelene Sheila Quinsey;Ainsley L Greedy;Stephen Paul Bottomley;James C Whisstock

213
Citations
Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes

Jan Potempa;Robert Pike;James Travis

212
Citations
Cleavage and activation of proteinase‐activated receptor‐2 on human neutrophils by gingipain‐R from Porphyromonas gingivalis

Afrodite Lourbakos;Carla Chinni;Philip E Thompson;Jan Potempa

197
Citations
Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans

Robert Neil Pike;Ashley Maurice Buckle;Bernard Le Bonniec;Frank C Church

170
Citations