World's Best Scientists 2026 revealed!

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Microbiology

D-Index
101
Citations
36970
World Ranking
386
National Ranking
176

Research.com Recognitions

  • 2011 - Prize of the Foundation for Polish Science - Nagroda Fundacji na rzecz Nauki Polskiej for the characterization of a new family of bacterial proteases and for demonstration of their role in the development of periodontal disease

Overview

Jan Potempa is affiliated with the University of Louisville in the United States and has made significant contributions to research primarily in the fields of Medicine, Dentistry, and Biochemistry, Genetics and Molecular Biology. Their work spans subfields such as Periodontics, Molecular Biology, Immunology, Public Health, Environmental and Occupational Health, and Infectious Diseases.

Potempa's research extensively covers topics related to oral health, particularly focusing on oral microbiology and periodontitis. Other prominent research topics include oral health pathology and treatment, streptococcal infections and treatments, immune response and inflammation, oral and gingival health research, HIV/AIDS oral health manifestations, and antimicrobial peptides and activities.

Frequent co-authors in Potempa's publications include Joanna Kozieł, Barbara Potempa, Jan J. Enghild, Ewelina Dobosz, and Ewa Bielecka.

Some of the venues where Potempa has most frequently published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • mBio
  • Molecular Oral Microbiology
  • The Journal of Immunology

Recent notable papers by Potempa include:

  • Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential, 2020, Clinical Epigenetics
  • The Role of Gingival Fibroblasts in the Pathogenesis of Periodontitis, 2023, Journal of Dental Research
  • Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis, 2020, Nature Microbiology
  • Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis, 2020, FEBS Journal
  • Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions, 2023, Cell

Potempa was awarded the Prize of the Foundation for Polish Science (Nagroda Fundacji na rzecz Nauki Polskiej) in 2011 for the characterization of a new family of bacterial proteases and the demonstration of their role in the development of periodontal disease.

Best Publications

  • Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

    Stephen S. Dominy;Casey Lynch;Florian Ermini;Malgorzata Benedyk

  • The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

    J Potempa;E Korzus;J Travis

  • Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis

    Natalia Wegner;Robin Wait;Aneta Sroka;Sigrun Eick

  • Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus-Derived Proteinases

    Magdalena Sieprawska-Lupa;Piotr Mydel;Katarzyna Krawczyk;Kinga Wójcik

  • A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages

    Malgorzata Kubica;Krzysztof Guzik;Joanna Koziel;Miroslaw Zarebski

  • Role of bacterial proteinases in matrix destruction and modulation of host responses

    Jan Potempa;Agnieszka Banbula;Jim Travis

  • Purification, Characterization, and Sequence Analysis of a Potential Virulence Factor from Porphyromonas gingivalis, Peptidylarginine Deiminase

    Walker T. McGraw;Jan Potempa;David Farley;James Travis

  • The case for periodontitis in the pathogenesis of rheumatoid arthritis

    Jan Potempa;Piotr Mydel;Joanna Koziel

  • Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon’s knife to a meat chopper‐like brutal degradation of proteins

    Yonghua Guo;Ky-Anh Nguyen;Jan Potempa

  • Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins.

    R. Pike;W. McGraw;J. Potempa;J. Travis

  • Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes.

    Jan Potempa;Aneta Sroka;Takahisa Imamura;James Travis

  • Corruption of innate immunity by bacterial proteases.

    Jan Potempa;Robert Neil Pike

  • New method for typing Staphylococcus aureus strains: multiple-locus variable-number tandem repeat analysis of polymorphism and genetic relationships of clinical isolates.

    Artur Sabat;Jolanta Krzyszton-Russjan;Wojciech Strzalka;Renata Filipek

  • The role and regulation of the extracellular proteases of Staphylococcus aureus.

    Lindsey Shaw;Ewa Golonka;Jan Potempa;Simon J. Foster

  • Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer

    Shegan Gao;Shuoguo Li;Zhikun Ma;Shuo Liang

  • The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function.

    Anna M. Lasica;Miroslaw Ksiazek;Miroslaw Ksiazek;Mariusz Madej;Jan Potempa;Jan Potempa

  • The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain.

    J Potempa;R Pike;J Travis

  • Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD).

    Katarzyna J. Maresz;Annelie Hellvard;Annelie Hellvard;Aneta Sroka;Karina Adamowicz

  • Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis.

    Z Chen;J Potempa;A Polanowski;M Wikstrom

  • Are bacterial proteinases pathogenic factors

    Jemes Travis;Jan Potempa;Hiroshi Maeda

  • Staphylococcus aureus Proteases Degrade Lung Surfactant Protein A Potentially Impairing Innate Immunity of the Lung

    Tomasz Kantyka;Krzysztof Pyrc;Milosz Gruca;Jan Smagur

Frequent Co-Authors

James Travis
James Travis University of Georgia
Jan J. Enghild
Jan J. Enghild Aarhus University
Robert N. Pike
Robert N. Pike La Trobe University
Krzysztof Pyrc
Krzysztof Pyrc Jagiellonian University
Anna M. Blom
Anna M. Blom Lund University
Patrick J. Venables
Patrick J. Venables University of Oxford
Kristian Riesbeck
Kristian Riesbeck Lund University
Richard J. Lamont
Richard J. Lamont University of Louisville
Peter Garred
Peter Garred University of Copenhagen
Anton Sculean
Anton Sculean University of Bern

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