World's Best Scientists 2026 revealed!

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Medicine

D-Index
82
Citations
24444
World Ranking
16126
National Ranking
501

Overview

Mikio Shoji is affiliated with Hirosaki University in Japan, with a primary research focus in the field of Medicine. Within this broad discipline, their work spans multiple subfields including Physiology, Psychiatry and Mental Health, Neurology, Molecular Biology, and Orthopedics and Sports Medicine. Shoji's research covers a range of topics such as Alzheimer's disease research and treatments, dementia and cognitive impairment research, muscle activation and electromyography studies, body composition measurement techniques, sports performance and training, amyloidosis diagnosis and treatment, and functional brain connectivity studies.

The scientist has contributed to several recent papers, including:

  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease, 2020, Nature Medicine
  • Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease, 2020, Biological Psychiatry
  • Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study, 2021, The Lancet Neurology
  • Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN), 2023, Nature Neuroscience
  • Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease, 2021, Neurology

Frequent collaborators in Shoji's work include Takeshi Kawarabayashi, Takumi Nakamura, Masamitsu Takatama, Yoshio Ikeda, and Naoko Nakahata. The number of joint publications ranges from 8 to 23 with these coauthors.

The research outputs from Shoji are often published in well-known scientific venues. The most frequent publication venues are:

  • Journal of Alzheimer's Disease
  • Alzheimer's & Dementia
  • Frontiers in Physiology
  • Internal Medicine
  • Journal of the Neurological Sciences

The scientist's work significantly relates to the study of neurodegenerative diseases, particularly focusing on Alzheimer's disease mechanisms, biomarkers, and clinical associations. This includes exploration of amyloid and tau pathologies and their clinical impacts on personality and cognition. Shoji's interdisciplinary approach bridges the understanding between neurological impairments and their physiological and molecular underpinnings, as seen in the range of topics including muscle activation and body composition, which align with broader concerns of aging and neurological health.

Best Publications

  • Production of the Alzheimer amyloid β protein by normal proteolytic processing

    Mikio Shoji;Todd E. Golde;Jorge Ghiso;Tobun T. Cheung

  • Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

    Takeshi Kawarabayashi;Takeshi Kawarabayashi;Linda H. Younkin;Takaomi C. Saido;Mikio Shoji

  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

    Oliver Preische;Oliver Preische;Stephanie A. Schultz;Anja Apel;Anja Apel;Jens Kuhle

  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.

    Nicolas R Barthélemy;Yan Li;Nelly Joseph-Mathurin;Brian A Gordon

  • Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2

    M C Moreira;S Klur;M Watanabe;A H Nemeth

  • Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

    Suzanne Wahrle;Pritam Das;Andrew C. Nyborg;Chris McLendon

  • Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan

    M. Kanai;E. Matsubara;K. Isoe;K. Urakami

  • Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

    Takeshi Kawarabayashi;Mikio Shoji;Linda H. Younkin;Lin Wen-Lang

  • Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

    Etsuro Matsubara;Tara Bryant-Thomas;Javier Pacheco Quinto;Tracey L. Henry

  • A protein secretion system linked to bacteroidete gliding motility and pathogenesis

    Keiko Sato;Mariko Naito;Hideharu Yukitake;Hideki Hirakawa

  • Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer’s disease

    Yasumasa Ohyagi;Hideaki Asahara;De Hua Chui;Yuko Tsuruta

  • A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by β protein immunostaining

    H. Yamaguchi;S. Hirai;M. Morimatsu;M. Shoji

  • Determination of the Genome Sequence of Porphyromonas gingivalis Strain ATCC 33277 and Genomic Comparison with Strain W83 Revealed Extensive Genome Rearrangements in P. gingivalis

    Mariko Naito;Hideki Hirakawa;Atsushi Yamashita;Naoya Ohara

  • Diffuse type of senile plaques in the brains of Alzheimer-type dementia.

    H. Yamaguchi;S. Hirai;M. Morimatsu;M. Shoji

  • Combination assay of CSF Tau, Aβ1-40 and Aβ1-42(43) as a biochemical marker of Alzheimer's disease

    Mikio Shoji;Etsuro Matsubara;Mitsuyasu Kanai;Mitsunori Watanabe

  • Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.

    Yasuo Harigaya;Takaomi C. Saido;Christopher B. Eckman;Cristian Mihail Prada

  • JNK activation is associated with intracellular β-amyloid accumulation

    Mikio Shoji;Noboru Iwakami;Sousuke Takeuchi;Masaaki Waragai

  • Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease.

    Y. Harigaya;M. Shoji;T. Shirao;S. Hirai

  • Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia

    Masanori Iwai;Keiko Sato;Nobuhiko Omori;Isao Nagano

  • α1‐Antichymotrypsin as a possible biochemical marker for Alzheimer‐type dementia

    Etsuro Matsubara;Shunsaku Hirai;Masakuni Amari;Mikio Shoji

Frequent Co-Authors

Koji Abe
Koji Abe Okayama University
Koji Nakayama
Koji Nakayama Nagasaki University
Hiroyuki Arai
Hiroyuki Arai University of Tokyo
Yasuo Ihara
Yasuo Ihara Doshisha University
Yasuto Itoyama
Yasuto Itoyama Tohoku University
Ryozo Kuwano
Ryozo Kuwano Niigata University
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Masatoshi Takeda
Masatoshi Takeda Izumi University

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