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D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
38308
World Ranking
2395
National Ranking
1271

Overview

Jorge Ghiso is affiliated with New York University in the United States and has contributed extensively to research in medicine, with a particular focus on Alzheimer's disease and related neurological conditions. Their work spans biochemistry, genetics, and molecular biology, with significant engagement in physiology and molecular biology as subfields.

The scientist's research primarily addresses Alzheimer's disease research and treatments, alongside related topics such as dementia and cognitive impairment, nuclear receptors and signaling, genomics, phytochemicals, oxidative stress, computational drug discovery methods, clusterin in disease pathology, and epigenetics and DNA methylation.

Recent publications include:

  • Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain (2020, Molecular Psychiatry)
  • Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage (2020, Alzheimer s Research & Therapy)
  • Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis (2020, Aging Cell)
  • N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer's disease (2020, Neuropathology and Applied Neurobiology)
  • "Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain" (2020, bioRxiv (Cold Spring Harbor Laboratory))

Frequent co-authors include Agueda Rostagno, John Hardy, André Strydom, Dean Nižetić, and Tammaryn Lashley, reflecting collaborative work across various aspects of neuroscience and neurodegenerative research.

Common publication venues for Jorge Ghiso's work are The FASEB Journal, Molecular Psychiatry, Alzheimer s Research & Therapy, Neuropathology and Applied Neurobiology, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Production of the Alzheimer amyloid β protein by normal proteolytic processing

    Mikio Shoji;Todd E. Golde;Jorge Ghiso;Tobun T. Cheung

  • RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.

    Rashid Deane;Shi Du Yan;Ram Kumar Submamaryan;Barbara LaRue

  • Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

    Masayoshi Shibata;Shinya Yamada;S. Ram Kumar;Miguel Calero

  • Amyloid ion channels: A common structural link for protein-misfolding disease

    Arjan Quist;Ivo Doudevski;Hai Lin;Rushana Azimova

  • Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

    Melanie Meyer-Luehmann;Janaky Coomaraswamy;Tristan Bolmont;Tristan Bolmont;Stephan Kaeser

  • A stop-codon mutation in the BRI gene associated with familial British dementia

    Ruben Vidal;Blas Frangione;Agueda Rostagno;Simon Mead

  • Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid *

    Yau Jan Chyan;Burkhard Poeggeler;Rawhi A. Omar;Daniel G. Chain

  • Inhibition of Alzheimer β-Fibrillogenesis by Melatonin

    Miguel Pappolla;Peter Bozner;Claudio Soto;Haiyan Shao

  • Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).

    Jorge Ghiso;Olafur Jensson;Blas Frangione

  • Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

    B V Zlokovic;C L Martel;E Matsubara;J G McComb

  • Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

    Etsuro Matsubara;Tara Bryant-Thomas;Javier Pacheco Quinto;Tracey L. Henry

  • A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

    Ruben Vidal;Tamas Révész;Agueda Rostagno;Eugene Kim

  • The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.

    J. Ghiso;E. Matsubara;A. Koudinov;Nam Ho Choi-Miura

  • Apolipoprotein E : binding to soluble Alzheimer's β-amyloid

    T. Wisniewski;A. Golabek;E. Matsubara;J. Ghiso

  • Fate of Cerebrospinal Fluid‐Borne Amyloid β‐Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries

    J.-F. Ghersi-Egea;P. D. Gorevic;J. Ghiso;B. Frangione

  • Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

    J. B. Mackic;M. Stins;J. McComb;M. Calero

  • Apolipoprotein J (clusterin) and Alzheimer's disease.

    Miguel Calero;Agueda Rostagno;Etsuro Matsubara;Berislav Zlokovic

  • Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

    Takahiko Tokuda;Miguel Calero;Etsuro Matsubara;Ruben Vidal

  • Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke

    Blas Frangione;Jorge Ghiso

Frequent Co-Authors

Blas Frangione
Blas Frangione New York University
Tamas Revesz
Tamas Revesz University College London
Gordon T. Plant
Gordon T. Plant University College London
Janice L. Holton
Janice L. Holton University College London
Thomas Wisniewski
Thomas Wisniewski New York University
Berislav V. Zlokovic
Berislav V. Zlokovic University of Southern California
Miguel A. Pappolla
Miguel A. Pappolla The University of Texas Medical Branch at Galveston
Thomas A. Neubert
Thomas A. Neubert New York University
Frances Prelli
Frances Prelli New York University
Asok Kumar
Asok Kumar Nathan Kline Institute for Psychiatric Research

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