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Neuroscience

D-Index
55
Citations
14131
World Ranking
4653
National Ranking
2096

Overview

Miguel A. Pappolla is affiliated with The University of Texas Medical Branch at Galveston in the United States. Their research covers multiple aspects of medicine, biochemistry, genetics, and molecular biology, with particular focus on neurodegenerative diseases and related physiological mechanisms.

Their recent academic contributions include studies on Alzheimer's disease, pain management, and neurodegeneration. Notable papers published by Miguel A. Pappolla are:

  • "Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease," 2021, Neurobiology of Disease
  • "Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia," 2021, Pain Physician
  • "Oxidative Stress in Alzheimer's Disease: The Shortcomings of Antioxidant Therapies," 2024, Journal of Alzheimer s Disease

Co-authorship is a significant aspect of their scientific work, frequently collaborating with researchers such as Kumar Sambamurti, Xiang Fang, Burkhard Pöeggeler, George Perry, and Sandeep Kumar Singh. These collaborations have contributed to advancing knowledge in areas overlapping neuroscience and molecular biology.

The scholar's research emphasizes several main topics including:

  • Alzheimer's disease research and treatments
  • Tryptophan and brain disorders
  • Diet and metabolism studies
  • Gut microbiota and health
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Neuroinflammation and Neurodegeneration Mechanisms

They have published extensively in journals that focus on neurological and biochemical sciences. The most frequent venues for their research publications include:

  • Journal of Alzheimer s Disease
  • Alzheimer s & Dementia
  • International Journal of Molecular Sciences
  • Preprints.org
  • Pain Physician

Miguel A. Pappolla's work spans several subfields of study such as physiology, molecular biology, neurology, biological psychiatry, and surgery. The integration of these disciplines supports their exploration of complex interactions underlying neurodegenerative conditions and metabolic disorders.

Best Publications

  • Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

    Lorenzo M. Refolo;Miguel A. Pappolla;Brian Malester;John LaFrancois

  • RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer's Disease

    Akihiko Nunomura;George Perry;Miguel A. Pappolla;Ramon Wade

  • Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

    Mark A. Smith;Keisuke Hirai;Karen Hsiao;Miguel A. Pappolla

  • A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

    L. M. Refolo;Miguel Pappolla;J. LaFrancois;B. Malester

  • Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide

    Miguel A. Pappolla;Melisa Sos;Rawhi A. Omar;Roger J. Bick

  • Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

    Miguel Pappolla;R. A. Omar;K. S. Kim;N. K. Robakis

  • Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo

    M. A. Pappolla;Y. J. Chyan;R. A. Omar;K. Hsiao

  • Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid *

    Yau Jan Chyan;Burkhard Poeggeler;Rawhi A. Omar;Daniel G. Chain

  • Inhibition of Alzheimer β-Fibrillogenesis by Melatonin

    Miguel Pappolla;Peter Bozner;Claudio Soto;Haiyan Shao

  • Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

    Akihiko Nunomura;Akihiko Nunomura;George Perry;Miguel A. Pappolla;Robert P. Friedland

  • Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

    Miguel Pappolla;T. K. Bryant-Thomas;D. Herbert;J. Pacheco

  • Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

    Etsuro Matsubara;Tara Bryant-Thomas;Javier Pacheco Quinto;Tracey L. Henry

  • Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer's Disease

    Robert J. Baranello;Krishna L. Bharani;Vasudevaraju Padmaraju;Nipun Chopra

  • Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

    Youssef Zaim Wadghiri;Einar M. Sigurdsson;Marcin Sadowski;James I. Elliott

  • An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease.

    Miguel Pappolla;Y. J. Chyan;B. Poeggeler;B. Frangione

  • Luteinizing hormone modulates cognition and amyloid-β deposition in Alzheimer APP transgenic mice

    Gemma Casadesus;Kate M. Webber;Craig S. Atwood;Miguel A. Pappolla

  • Statin therapy for Alzheimer's disease: will it work?

    Suzana S. Petanceska;Steven DeRosa;Vicki Olm;Nichole Diaz

  • Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease

    Paul E. Bendheim;Burkhard Poeggeler;Eyal Neria;Vivi Ziv

  • Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease.

    Rawhi A. Omar;Y.-J. Chyan;Anne C. Andorn;Burkhart Poeggeler

  • Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the alzheimer amyloid Aβ peptidet

    Burkhard Poeggeler;Leticia Miravalle;Michael G. Zagorski;Thomas Wisniewski

  • Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

    K. Sambamurti;J. Shioi;J. P. Anderson;Miguel Pappolla

Frequent Co-Authors

Kumar Sambamurti
Kumar Sambamurti Medical University of South Carolina
Karen Duff
Karen Duff University College London
Nicolas G. Bazan
Nicolas G. Bazan Louisiana State University
Mary Sano
Mary Sano Icahn School of Medicine at Mount Sinai
Christina L. Williams
Christina L. Williams Duke University
Inge Grundke-Iqbal
Inge Grundke-Iqbal University of York
Stephen D. Schmidt
Stephen D. Schmidt National Institutes of Health
Claudio Soto
Claudio Soto The University of Texas Health Science Center at Houston
Walter J. Lukiw
Walter J. Lukiw Louisiana State University

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