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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
13942
World Ranking
9719
National Ranking
4278

Overview

Nikolaos K. Robakis is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. The main topics of their work focus on Alzheimer's disease research and treatments, computational drug discovery methods, and neurodegenerative disease mechanisms.

Their recent publications include:

  • The amyloid cascade hypothesis: an updated critical review (2023, Brain)
  • The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes (2023, Journal of Alzheimer s Disease)
  • Passive Alzheimer's immunotherapy: A promising or uncertain option? (2023, Ageing Research Reviews)
  • Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit (2024, Ageing Research Reviews)
  • Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling (2022, Nature Cell Biology)

Frequent co-authors collaborating with Nikolaos K. Robakis include:

  • Kasper P. Kepp
  • Anastasios Georgakopoulos
  • Poul Flemming Høilund-Carlsen
  • Stefano L. Sensi
  • Bryce Vissel

Robakis's research is frequently published in venues such as:

  • Ageing Research Reviews
  • Alzheimer s & Dementia
  • Brain
  • Journal of Alzheimer s Disease
  • Molecular Psychiatry

Their subfields of study highlight expertise in molecular biology, physiology, computational theory and mathematics, neurology, and cellular and molecular neuroscience. Key research topics explored include Alzheimer's disease research and treatments, computational drug discovery methods, cholinesterase and neurodegenerative diseases, amyloidosis diagnosis and treatment outcomes, angiogenesis and VEGF in cancer, neuroinflammation and neurodegeneration mechanisms, and dementia and cognitive impairment research.

Best Publications

  • A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions

    Philippe Marambaud;Junichi Shioi;Geo Serban;Anastasios Georgakopoulos

  • Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

    Nikolaos K. Robakis;Narayanarao Ramakrishna;Gloria Wolfe;Henryk M. Wisniewski

  • A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

    Philippe Marambaud;Paul H Wen;Anindita Dutt;Junichi Shioi

  • Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

    Miguel Pappolla;R. A. Omar;K. S. Kim;N. K. Robakis

  • Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome.

    Nikolaos K. Robakis;Henryk M. Wisniewski;Edmund C. Jenkins;Evelyn A. Devine-Gage

  • Alzheimer's disease: a re-examination of the amyloid hypothesis

    Rachael L. Neve;Nikolaos K. Robakis

  • Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

    Sanjay W. Pimplikar;Ralph A. Nixon;Nikolaos K. Robakis;Jie Shen

  • PS1 activates PI3K thus inhibiting GSK‐3 activity and tau overphosphorylation: effects of FAD mutations

    Lia Baki;Junichi Shioi;Paul Wen;Zhiping Shao

  • Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells.

    John P. Anderson;Fred S. Esch;Pamela S. Keim;Kumar Sambamurti

  • Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

    Anastasios Georgakopoulos;Philippe Marambaud;Spiros Efthimiopoulos;Junichi Shioi

  • A Role for Noncoding Variation in Schizophrenia

    Panos Roussos;Amanda C. Mitchell;Georgios Voloudakis;John F. Fullard

  • Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.

    Lia Baki;Philippe Marambaud;Spiros Efthimiopoulos;Anastasios Georgakopoulos

  • The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

    Paul H. Wen;Patrick R. Hof;Xiaoping Chen;Karen Gluck

  • Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling.

    Anastasios Georgakopoulos;Claudia Litterst;Enrico Ghersi;Lia Baki

  • Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

    K. Sambamurti;J. Shioi;J. P. Anderson;Miguel Pappolla

  • A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease.

    P. G. Vallet;R. Guntern;P. R. Hof;J. Golaz

  • Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains.

    R J Kascsak;R Rubenstein;P A Merz;R I Carp

  • Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues

    Nikolaos K. Robakis;Prithvi R. Sawh;Gloria C. Wolfe;Richard Rubenstein

  • Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor

    Claudia Litterst;Anastasios Georgakopoulos;Junichi Shioi;Enrico Ghersi

  • Nerve and epidermal growth factors induce the release of the Alzheimer Amyloid precursor from PC 12 cell cultures

    Lawrence M. Refolo;Steven R.J. Salton;John P. Anderson;Pankaj Mehta

Frequent Co-Authors

Philippe Marambaud
Philippe Marambaud Feinstein Institute for Medical Research
Vahram Haroutunian
Vahram Haroutunian Icahn School of Medicine at Mount Sinai
Gregory A. Elder
Gregory A. Elder Icahn School of Medicine at Mount Sinai
Menelas N. Pangalos
Menelas N. Pangalos AstraZeneca (United Kingdom)
Patrick R. Hof
Patrick R. Hof Icahn School of Medicine at Mount Sinai
Henryk M. Wisniewski
Henryk M. Wisniewski University of York
Rachael L. Neve
Rachael L. Neve Harvard University
Constantin Bouras
Constantin Bouras University of Geneva
Panos Roussos
Panos Roussos Icahn School of Medicine at Mount Sinai
Miguel A. Pappolla
Miguel A. Pappolla The University of Texas Medical Branch at Galveston

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