World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
21689
World Ranking
5027
National Ranking
375

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Menelas N. Pangalos is affiliated with AstraZeneca in the United Kingdom and has contributed extensively to research primarily in medicine and biochemistry, genetics, and molecular biology. Their work spans several interrelated fields, focusing significantly on infectious diseases, genetics, and molecular biology.

The scientist's research interests are reflected in their documented subfields of study, which include infectious diseases, genetics, molecular biology, physiology, and cancer research. Their main topics of work further illustrate this focus, covering SARS-CoV-2 and COVID-19 research, genomics and rare diseases, genetic associations and epidemiology, COVID-19 clinical research studies, SARS-CoV-2 detection and testing, epigenetics and DNA methylation, and cancer genomics and diagnostics.

Menelas N. Pangalos has published in various reputable venues, with notable frequent publication outlets being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Genetics
  • The Lancet Respiratory Medicine
  • Science Translational Medicine

Among the recent papers associated with Pangalos are:

  • Rare variant contribution to human disease in 281,104 UK Biobank exomes (2021, Nature)
  • Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank (2021, Nature Genetics)
  • Efficacy and safety of intramuscular administration of tixagevimab-cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial (2022, The Lancet Respiratory Medicine)
  • The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans (2022, Science Translational Medicine)
  • Rare variant associations with plasma protein levels in the UK Biobank (2023, Nature)

Frequent collaborators in Pangalos's research include:

  • Ryan S. Dhindsa
  • Katherine R. Smith
  • Slavé Petrovski
  • Quanli Wang
  • Dimitrios Vitsios

The scientist holds the distinction of being a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

    David Cook;Dearg Brown;Robert Alexander;Ruth March

  • Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

    J. Steven Jacobsen;Chi-Cheng Wu;Jeffrey M. Redwine;Thomas A. Comery

  • Rapamycin alleviates toxicity of different aggregate-prone proteins.

    Zdenek Berger;Brinda Ravikumar;Fiona M. Menzies;Lourdes Garcia Oroz

  • Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory.

    Feng Liu;Mark Day;Luis C Muñiz;Daniel Bitran

  • Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

    Ying Gao;Dmitry V. Vasilyev;Maria Beatriz Goncalves;Fiona V. Howell

  • Drug development for CNS disorders: strategies for balancing risk and reducing attrition.

    Menelas N. Pangalos;Lee E. Schechter;Orest Hurko

  • Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.

    David R Riddell;Hua Zhou;Kevin Atchison;Helen K Warwick

  • Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.

    Andrew D. Medhurst;Gillian Rennie;Conrad G. Chapman;Helen Meadows

  • Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

    C. Jaillard;S. Harrison;B. Stankoff;M. S. Aigrot

  • Impact of a five-dimensional framework on R&D productivity at AstraZeneca

    Paul Morgan;Dean G Brown;Simon Lennard;Mark J Anderton

  • Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine.

    Ann R Falsey;Magdalena E Sobieszczyk;Ian Hirsch;Stephanie Sproule

  • mRNA distribution analysis of human TRPC family in CNS and peripheral tissues.

    Antonio Riccio;Andrew D Medhurst;Cesar Mattei;Rosemary E Kelsell

  • GABAB receptors: a new paradigm in G protein signaling.

    Andrés Couve;Stephen J. Moss;Menelas N. Pangalos

  • The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin.

    Verena Tretter;Tija C. Jacob;Jayanta Mukherjee;Jean-Marc Fritschy

  • Rare variant contribution to human disease in 281,104 UK Biobank exomes.

    Quanli Wang;Ryan S. Dhindsa;Keren Carss;Andrew R. Harper

  • The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

    David R. Riddell;Hua Zhou;Thomas A. Comery;Evguenia Kouranova

  • Acute γ-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease

    Thomas A. Comery;Robert L. Martone;Suzan Aschmies;Kevin P. Atchison

  • Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.

    Haydn M. Prosser;Catherine H. Gill;Warren D. Hirst;Evelyn Grau

  • The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models.

    Andrew D Medhurst;David C Harrison;Simon J Read;Colin A Campbell

  • GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

    Melanie J. Robbins;Andrew R. Calver;Alexander K. Filippov;Warren D. Hirst

Frequent Co-Authors

Stephen J. Moss
Stephen J. Moss Tufts University
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Andrew D. Randall
Andrew D. Randall University of Exeter
Nikolaos K. Robakis
Nikolaos K. Robakis Icahn School of Medicine at Mount Sinai
Jon T. Brown
Jon T. Brown University of Exeter
Jeannie Chin
Jeannie Chin Baylor College of Medicine
Philip G. Haydon
Philip G. Haydon Tufts University
Frank S. Walsh
Frank S. Walsh Wolfson Centre for Age-Related Diseases
Patrick Doherty
Patrick Doherty King's College London
Neil Upton
Neil Upton Transpharmation, UK

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