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Biology and Biochemistry
USA
2026

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Best Scientists

D-Index
165
Citations
94864
World Ranking
1052
National Ranking
624

Biology and Biochemistry

D-Index
169
Citations
98222
World Ranking
94
National Ranking
70

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Benjamin F. Cravatt is affiliated with the Scripps Research Institute in the United States. Their research spans multiple fields including biochemistry, genetics, molecular biology, and medicine, with a strong emphasis on molecular biology and organic chemistry. Their work also covers oncology, pharmacology, and immunology.

The main topics of Cravatt's research include:

  • Protein Degradation and Inhibitors
  • Click Chemistry and Applications
  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Cannabis and Cannabinoid Research
  • RNA modifications and cancer
  • Chemical Synthesis and Analysis

Frequent publication venues for Cravatt include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Chemical Biology
  • Journal of the American Chemical Society
  • ACS Chemical Biology
  • Cell chemical biology

Regular collaborators in their work are:

  • Bruno Melillo
  • Micah J. Niphakis
  • Daisuke Ogasawara
  • Gabriel M. Simon
  • Evert Njomen

Recent papers authored or co-authored by Cravatt include:

  • An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells, 2020, Cell
  • Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries, 2021, Nature Biotechnology
  • Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions, 2020, Cell Research
  • A proteome-wide atlas of lysine-reactive chemistry, 2021, Nature Chemistry
  • DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras, 2021, Journal of the American Chemical Society

Benjamin F. Cravatt has received the following professional recognitions:

  • Fellow of the American Academy of Arts and Sciences, 2016
  • Fellow of the American Association for the Advancement of Science (AAAS), 2007

Best Publications

  • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

    Benjamin F. Cravatt;Dan K. Giang;Stephen P. Mayfield;Dale L. Boger

  • Quantitative reactivity profiling predicts functional cysteines in proteomes

    Eranthie Weerapana;Chu Wang;Gabriel M. Simon;Florian Richter

  • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

    Benjamin F. Cravatt;Kristin Demarest;Matthew P. Patricelli;Michael H. Bracey

  • Activity-based protein profiling: The serine hydrolases

    Yongsheng Liu;Matthew P. Patricelli;Benjamin F. Cravatt

  • Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

    Benjamin F. Cravatt;Aaron T. Wright;John W. Kozarich

  • Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

    Anna E. Speers;Gregory C. Adam;Benjamin F. Cravatt

  • A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol

    Jacqueline Lorayne Blankman;Gabriel M. Simon;Benjamin F. Cravatt

  • Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

    Lindsey J. Macpherson;Adrienne E. Dubin;Michael J. Evans;Felix Marr;Felix Marr

  • Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

    Jonathan Z Long;Weiwei Li;Lamont Booker;James J Burston

  • Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

    Daniel K. Nomura;Jonathan Z. Long;Sherry Niessen;Heather S. Hoover

  • Profiling Enzyme Activities In Vivo Using Click Chemistry Methods

    Anna E Speers;Benjamin F Cravatt

  • How many human proteoforms are there

    Ruedi Aebersold;Jeffrey N. Agar;I. Jonathan Amster;Mark S. Baker

  • Proteome-wide covalent ligand discovery in native biological systems

    Keriann M. Backus;Bruno E. Correia;Kenneth M. Lum;Stefano Forli

  • The promise and peril of chemical probes.

    Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  • STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

    Michele K. McKinney;Benjamin F. Cravatt

  • The biological impact of mass-spectrometry-based proteomics

    Benjamin F. Cravatt;Gabriel M. Simon;John R. Yates

  • Chemical characterization of a family of brain lipids that induce sleep.

    Benjamin F. Cravatt;Oscar Prospero-Garcia;Gary Siuzdak;Norton B. Gilula

  • Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

    Daniel K. Nomura;Daniel K. Nomura;Bradley E. Morrison;Jacqueline L. Blankman;Jonathan Z. Long

  • Mechanism-based profiling of enzyme families.

    Michael J Evans;Benjamin F Cravatt

  • The endocannabinoid system drives neural progenitor proliferation

    Tania Aguado;Krisztina Monory;Javier Palazuelos;Nephi Stella

Frequent Co-Authors

Aron H. Lichtman
Aron H. Lichtman Virginia Commonwealth University
Dale L. Boger
Dale L. Boger Scripps Research Institute
Sherry Niessen
Sherry Niessen Pfizer (United States)
Hugh Rosen
Hugh Rosen Scripps Research Institute
Daniel K. Nomura
Daniel K. Nomura University of California, Berkeley
Alan Saghatelian
Alan Saghatelian Salk Institute for Biological Studies
Richard A. Lerner
Richard A. Lerner Scripps Research Institute
Eranthie Weerapana
Eranthie Weerapana Boston College
Ken Mackie
Ken Mackie Indiana University
Raymond C. Stevens
Raymond C. Stevens University of Southern California

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