World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
87
Citations
26596
World Ranking
2837
National Ranking
1457

Overview

Hugh Rosen is affiliated with the Scripps Research Institute in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, neuroscience, and medicine with a focus on molecular mechanisms and cellular processes.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Neuroscience

Within these broad areas, their subfields of study cover:

  • Molecular Biology
  • Physiology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Cell Biology

Rosen's work is particularly concentrated on topics such as:

  • Sphingolipid Metabolism and Signaling
  • Pain Mechanisms and Treatments
  • Neuropeptides and Animal Physiology
  • Lipid Membrane Structure and Behavior
  • Sleep and Wakefulness Research
  • Ion channel regulation and function
  • Endoplasmic Reticulum Stress and Disease

Their recent publications illustrate a focus on neurobiology and immunological mechanisms:

  • "Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance," 2022, Brain
  • "Opposing Effects on Descending Control of Nociception by µ and κ Opioid Receptors in the Anterior Cingulate Cortex," 2023, Anesthesiology
  • "The riddle of the Sphinx: why sphingosine-1-phosphate may help define molecular mechanisms underlying risk stratification for serious COVID-19 infections," 2020, EMBO Molecular Medicine
  • "S1P1 Contributes to Endotoxin-enhanced B-Cell Functions Involved in Hypersensitivity Pneumonitis," 2020, American Journal of Respiratory Cell and Molecular Biology
  • "The discovery and development of the sphingosine 1-phosphate receptor modulator ozanimod in ulcerative colitis," 2024, Advances in pharmacology

The frequent coauthors with whom Rosen collaborates include:

  • Edita Navratilova
  • Miguel Guerrero
  • Volker Neugebauer
  • Frank Porreca
  • Hisakatsu Ito

Publication venues where Rosen has contributed multiple times reflect the interdisciplinary nature of their research:

  • Brain
  • Anesthesiology
  • EMBO Molecular Medicine
  • American Journal of Respiratory Cell and Molecular Biology
  • Advances in pharmacology

Best Publications

  • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

    Suzanne Mandala;Richard Hajdu;James Bergstrom;Elizabeth Quackenbush

  • Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

    Hugh Rosen;Edward J. Goetzl

  • Crystal Structure of a Lipid G Protein–Coupled Receptor

    Michael A. Hanson;Christopher B. Roth;Euijung Jo;Mark T. Griffith

  • Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection

    John R. Teijaro;Kevin B. Walsh;Stuart M. Cahalan;Daniel M. Fremgen

  • Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve.

    E. R. Lunn;V. H. Perry;M. C. Brown;H. Rosen

  • Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

    M. Germana Sanna;Jiayu Liao;Euijung Jo;Christopher Alfonso

  • Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy.

    Qian Gong;Qinglin Ou;Shiming Ye;Wyne P. Lee

  • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

    Nicolas Fazilleau;Louise J McHeyzer-Williams;Hugh Rosen;Michael G McHeyzer-Williams

  • Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

    Hui Zheng;Daniel Fletcher;Wieslaw Kozak;Minghao Jiang

  • Sphingosine 1-Phosphate Receptor Signaling

    Hugh Rosen;Pedro J. Gonzalez-Cabrera;M. Germana Sanna;Steven Brown

  • Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P 1 antagonist in vivo

    M Germana Sanna;Sheng-Kai Wang;Pedro J Gonzalez-Cabrera;Pedro J Gonzalez-Cabrera;Anthony Don

  • Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

    Thomas Blankenstein;Zheng Hong Qin;K Uberla;Werner Muller

  • Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo.

    H Rosen;S Gordon

  • The Antifungal Echinocandin Caspofungin Acetate Kills Growing Cells of Aspergillus fumigatus In Vitro

    J. C. Bowman;P. Scott Hicks;M. B. Kurtz;H. Rosen

  • Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

    M. Forrest;S.-Y. Sun;R. Hajdu;J. Bergstrom

  • The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.

    Raymond C. Stevens;Vadim Cherezov;Vsevolod Katritch;Ruben Abagyan

  • Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

    Tsui-Fen Chou;Steve J. Brown;Dmitriy Minond;Brian E. Nordin

  • Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

    Frank Niessen;Florence Schaffner;Christian Furlan-Freguia;Rafal Pawlinski

  • Two-site binding of C5a by its receptor: An alternative binding paradigm for G protein-coupled receptors

    S J Siciliano;T E Rollins;J DeMartino;Z Konteatis

  • Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

    Sindy H Wei;Hugh Rosen;Melanie P Matheu;M Germana Sanna

Frequent Co-Authors

Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
Michael B. A. Oldstone
Michael B. A. Oldstone Scripps Research Institute
William R. Roush
William R. Roush Scripps Research Institute
John R. Teijaro
John R. Teijaro Scripps Research Institute
Jerold Chun
Jerold Chun Sanford Burnham Prebys Medical Discovery Institute
Siamon Gordon
Siamon Gordon University of Oxford
Jeffrey J. Hale
Jeffrey J. Hale MSD (United States)
Raymond J. Deshaies
Raymond J. Deshaies California Institute of Technology
Yoshihiro Kawaoka
Yoshihiro Kawaoka University of Tokyo
Michael D. Cameron
Michael D. Cameron Scripps Research Institute

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