World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
42638
World Ranking
2060
National Ranking
1125

Overview

Richard L. Proia is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with significant contributions in molecular biology, physiology, neurology, cell biology, and immunology.

The scientist's work primarily focuses on the following research topics:

  • Sphingolipid Metabolism and Signaling
  • Lysosomal Storage Disorders Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cellular Transport and Secretion
  • Lipid Membrane Structure and Behavior
  • Endoplasmic Reticulum Stress and Disease
  • Ion Transport and Channel Regulation

Richard L. Proia has published extensively in well-known venues, demonstrating a focus on both basic and translational biology. Frequent publication venues for their work include:

  • The FASEB Journal
  • Molecular Genetics and Metabolism
  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation Research

Their recent papers illustrate an emphasis on endothelial signaling, sphingolipid biology, genetics, and vascular integrity. Selected publications include:

  • Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke, 2020, Circulation Research
  • Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta, 2020, eLife
  • Programming to S1PR1 + Endothelial Cells Promotes Restoration of Vascular Integrity, 2021, Circulation Research
  • A genome-wide CRISPR/Cas9 screen reveals that the aryl hydrocarbon receptor stimulates sphingolipid levels, 2020, Journal of Biological Chemistry
  • Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease, 2020, Cellular Signalling

Collaboration is also a significant aspect of their work, with frequent co-authors including:

  • Mari Kono
  • Colleen Byrnes
  • Galina Tuymetova
  • Hongling Zhu
  • Cynthia J. Tifft

Overall, Richard L. Proia's body of work contributes toward understanding biochemical and molecular mechanisms underlying cellular function and disease, particularly in contexts involving lipid signaling and neurodegeneration.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

    Mehrdad Matloubian;Charles G. Lo;Guy Cinamon;Matthew J. Lesneski

  • Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

    Yujing Liu;Ryuichi Wada;Tadashi Yamashita;Yide Mi

  • Lysosomal Glycosphingolipid Recognition by NKT Cells

    Dapeng Zhou;Jochen Mattner;Carlos Cantu;Nicolas Schrantz

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Essential role for sphingosine kinases in neural and vascular development.

    Kiyomi Mizugishi;Tadashi Yamashita;Ana Olivera;Georgina F. Miller

  • The alliance of sphingosine-1-phosphate and its receptors in immunity

    Juan Rivera;Richard L. Proia;Ana Olivera

  • Enhanced insulin sensitivity in mice lacking ganglioside GM3

    Tadashi Yamashita;Akira Hashiramoto;Martin Haluzik;Hiroki Mizukami

  • A vital role for glycosphingolipid synthesis during development and differentiation

    Tadashi Yamashita;Ryuichi Wada;Teiji Sasaki;Chuxia Deng

  • Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

    Masaru Ishii;Jackson G. Egen;Frederick Klauschen;Martin Meier-Schellersheim

  • Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

    Maria L. Allende;Jennifer L. Dreier;Suzanne Mandala;Richard L. Proia

  • Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

    Richard L. Proia;Timothy Hla

  • Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

    Maria L. Allende;Teiji Sasaki;Hiromichi Kawai;Ana Olivera

  • Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone

    Guy Cinamon;Mehrdad Matloubian;Matthew J Lesneski;Ying Xu

  • Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

    Kazunori Sango;Shoji Yamanaka;Shoji Yamanaka;Alexander Hoffmann;Yasuharu Okuda

  • The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis

    Mari Kono;Yide Mi;Yujing Liu;Teiji Sasaki

  • Prevention of Lysosomal Storage in Tay-Sachs Mice Treated with N-Butyldeoxynojirimycin

    F M Platt;G R Neises;G Reinkensmeier;M J Townsend

  • Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

    Kazim A. Sheikh;Ji Sun;Yujing Liu;Hiromichi Kawai

  • G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

    Maria L. Allende;Tadashi Yamashita;Richard L. Proia

  • Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

    Charles G. Lo;Ying Xu;Richard L. Proia;Jason G. Cyster

Frequent Co-Authors

Timothy Hla
Timothy Hla Harvard University
Konrad Sandhoff
Konrad Sandhoff University of Bonn
Kinuko Suzuki
Kinuko Suzuki University of North Carolina at Chapel Hill
Ana Olivera
Ana Olivera National Institutes of Health
Jacqueline N. Crawley
Jacqueline N. Crawley University of California, Davis
Teresa M. Dunn
Teresa M. Dunn Uniformed Services University of the Health Sciences
Juan Rivera
Juan Rivera National Institutes of Health
Chu-Xia Deng
Chu-Xia Deng University of Macau
Evelina Gatti
Evelina Gatti Aix-Marseille University
Christer Betsholtz
Christer Betsholtz Uppsala University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Richard L. Proia

Trending Scientists