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Molecular Biology

D-Index
75
Citations
24949
World Ranking
1182
National Ranking
612

Overview

Christopher U.T. Hellen is affiliated with SUNY Downstate Medical Center in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, cardiology and cardiovascular medicine, plant science, oncology, and infectious diseases.

Their work extensively covers topics such as:

  • RNA and protein synthesis mechanisms
  • Viral infections and immunology research
  • RNA modifications and cancer
  • RNA research and splicing
  • Plant virus research studies
  • RNA interference and gene delivery
  • RNA regulation and disease

Christopher U.T. Hellen has authored multiple research papers published in prominent scientific venues. Recent notable publications include:

  • "Extraction of mRNA from Stalled Ribosomes by the Ski Complex," 2020, Molecular Cell
  • "Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer," 2020, Viruses
  • "Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES," 2022, The EMBO Journal
  • "The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism," 2020, Cell Reports
  • "Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC," 2024, Nucleic Acids Research

Their frequent coauthors include:

  • Tatyana V. Pestova
  • Irina S. Abaeva
  • Yani Arhab
  • Zuben P. Brown
  • Joachim Frank

Christopher U.T. Hellen's publications are often found in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Viruses
  • Genes & Development
  • RNA

The combination of their fields of study and research topics highlights a focus on the mechanisms of RNA and protein synthesis, the molecular biology underlying viral infections, and the interplay between RNA modifications and cancer. Their research outputs contribute to advances in understanding RNA regulation, gene delivery systems, and viral translational mechanisms.

Best Publications

  • The mechanism of eukaryotic translation initiation and principles of its regulation

    Richard J. Jackson;Christopher U. T. Hellen;Tatyana V. Pestova

  • Internal ribosome entry sites in eukaryotic mRNA molecules

    Christopher U.T. Hellen;Peter Sarnow

  • Molecular mechanisms of translation initiation in eukaryotes.

    Tatyana V. Pestova;Victoria G. Kolupaeva;Ivan B. Lomakin;Evgeny V. Pilipenko

  • A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initation of hepatitis C and classical swine fever virus RNAs

    Tatyana V. Pestova;Ivan N. Shatsky;Simon P. Fletcher;Richard J. Jackson

  • Genetics of poliovirus.

    Eckard Wimmer;Christopher U. T. Hellen;Xuemei Cao

  • Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry

    T. V. Pestova;C. U. T. Hellen;I. N. Shatsky

  • Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

    Tatyana V. Pestova;Tatyana V. Pestova;Sergei I. Borukhov;Christopher U. T. Hellen

  • The joining of ribosomal subunits in eukaryotes requires eIF5B

    Tatyana V. Pestova;Ivan B. Lomakin;Joon H. Lee;Sang Ki Choi

  • Initiation of protein synthesis from the A site of the ribosome.

    Joan E Wilson;Tatyana V Pestova;Christopher U.T Hellen;Peter Sarnow

  • Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.

    T. V. Pestova;I. N. Shatsky;C. U. T. Hellen

  • A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.

    Christopher U. T. Hellen;Gary W. Witherell;Michael Schmid;Sang Hoon Shin

  • The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling

    Andrey V. Pisarev;Maxim A. Skabkin;Vera P. Pisareva;Olga V. Skabkina

  • A cell cycle-dependent protein serves as a template-specific translation initiation factor.

    Evgeny V. Pilipenko;Tatyana V. Pestova;Victoria G. Kolupaeva;Elena V. Khitrina

  • Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.

    Vera P Pisareva;Maxim A Skabkin;Christopher U T Hellen;Tatyana V Pestova

  • Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.

    Daria V. Sizova;Victoria G. Kolupaeva;Victoria G. Kolupaeva;Tatyana V. Pestova;Tatyana V. Pestova;Ivan N. Shatsky

  • Translation elongation after assembly of ribosomes on the Cricket paralysis virus internal ribosomal entry site without initiation factors or initiator tRNA.

    Tatyana V. Pestova;Christopher U.T. Hellen

  • Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP

    Anett Unbehaun;Sergei I. Borukhov;Christopher U.T. Hellen;Tatyana V. Pestova

  • Recycling of eukaryotic posttermination ribosomal complexes.

    Andrey V. Pisarev;Christopher U.T. Hellen;Tatyana V. Pestova;Tatyana V. Pestova

  • Termination and post-termination events in eukaryotic translation.

    Richard J Jackson;Christopher U T Hellen;Tatyana V Pestova

  • Cap-independent translation of picornavirus RNAs : structure and function of the internal ribosomal entry site

    Sung Key Jang;Tatyana V. Pestova;Christopher U.T. Hellen;Gary W. Witherell

Frequent Co-Authors

Tatyana V. Pestova
Tatyana V. Pestova SUNY Downstate Medical Center
Eckard Wimmer
Eckard Wimmer Stony Brook University
Ivan N. Shatsky
Ivan N. Shatsky Lomonosov Moscow State University
Gerhard Wagner
Gerhard Wagner Harvard University
Joachim Frank
Joachim Frank Columbia University
Anton A. Komar
Anton A. Komar Cleveland State University
Peter Sarnow
Peter Sarnow Stanford University
Marina V. Rodnina
Marina V. Rodnina Max Planck Society
Nahum Sonenberg
Nahum Sonenberg McGill University
Vadim I. Agol
Vadim I. Agol Lomonosov Moscow State University

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