World's Best Scientists 2026 revealed!
Leoš Shivaya Valášek

Leoš Shivaya Valášek

D-Index & Metrics

Molecular Biology

D-Index
42
Citations
6000
World Ranking
3033
National Ranking
6

Overview

Leoš Shivaya Valášek is affiliated with the Czech Academy of Sciences in the Czech Republic. Their research predominantly spans the field of Biochemistry, Genetics and Molecular Biology, specifically focusing on Molecular Biology, Cell Biology, Genetics, Parasitology, and Epidemiology.

The main topics of their scientific work include:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Genomics and Phylogenetic Studies
  • RNA regulation and disease
  • CRISPR and Genetic Engineering
  • Molecular Biology Techniques and Applications

Valášek has published extensively, contributing significantly to several high-impact venues. Frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nucleic Acids Research
  • Nature Structural & Molecular Biology
  • Cell Reports

Some notable recent papers include:

  • "Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes" (2020, Molecular Cell)
  • "Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment" (2023, Nature)
  • "Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts" (2020, Cell Reports)
  • "Increased expression of tryptophan and tyrosine tRNAs elevates stop codon readthrough of reporter systems in human cell lines" (2021, Nucleic Acids Research)
  • "Selective footprinting of 40S and 80S ribosome subpopulations (Sel-TCP-seq) to study translation and its control" (2022, Nature Protocols)

The coauthors who have collaborated most frequently with Valášek are:

  • Anna Herrmannová
  • Petra Beznosková
  • Zdeněk Paris
  • Julius Lukeš
  • Mahabub Pasha Mohammad

Best Publications

  • Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

    Tomáš Groušl;Pavel Ivanov;Ivana Frydlová;Pavla Vašicová

  • Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.

    Leoš Valášek;Klaus H. Nielsen;Fan Zhang;Christie A. Fekete

  • The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo

    Leoš Valášek;Amy A. Mathew;Byung-Sik Shin;Klaus H. Nielsen

  • eIF3a cooperates with sequences 5′ of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA

    Béla Szamecz;Edit Rutkai;Lucie Cuchalová;Vanda Munzarová

  • Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo.

    Leoš Valášek;Klaus H. Nielsen;Alan G. Hinnebusch

  • Eukaryotic Translation Initiation Factor 3 (eIF3) and eIF2 Can Promote mRNA Binding to 40S Subunits Independently of eIF4G in Yeast

    Antonina V. Jivotovskaya;Leoš Valášek;Alan G. Hinnebusch;Klaus H. Nielsen

  • 'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs).

    Leos Shivaya Valásek

  • A Unique ISR Program Determines Cellular Responses to Chronic Stress

    Bo-Jhih Guan;Vincent van Hoef;Raul Jobava;Orna Elroy-Stein

  • Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.

    Katsura Asano;Anath Shalev;Lon Phan;Klaus Nielsen

  • The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning

    Lucie Cuchalová;Tomáš Kouba;Anna Herrmannová;István Dányi

  • A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNAiMet

    Lon Phan;Lori W. Schoenfeld;Leoš Valášek;Klaus H. Nielsen

  • Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding.

    Leoš Valášek;Lon Phan;Lori W. Schoenfeld;Věra Valášková

  • Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control.

    Klaus H Nielsen;Béla Szamecz;Leoš Valášek;Antonina Jivotovskaya

  • The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons

    Wen-Ling Chiu;Susan Wagner;Anna Herrmannová;Laxminarayana Burela

  • Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells.

    Petra Beznosková;Lucie Cuchalová;Susan Wagner;Christopher J. Shoemaker

  • Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle.

    Leoš Shivaya Valášek;Jakub Zeman;Susan Wagner;Petra Beznosková

  • Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes

    Susan Wagner;Susan Wagner;Anna Herrmannová;Vladislava Hronová;Stanislava Gunišová

  • Translation initiation factor eIF3 promotes programmed stop codon readthrough

    Petra Beznosková;Susan Wagner;Myrte Esmeralda Jansen;Tobias von der Haar

  • Translation reinitiation relies on the interaction between eIF3a/TIF32 and progressively folded cis-acting mRNA elements preceding short uORFs.

    Vanda Munzarová;Josef Pánek;Stanislava Gunišová;István Dányi

  • Please do not recycle! Translation reinitiation in microbes and higher eukaryotes

    Stanislava Gunišová;Vladislava Hronová;Mahabub Pasha Mohammad;Alan G Hinnebusch

Frequent Co-Authors

Alan G. Hinnebusch
Alan G. Hinnebusch National Institutes of Health
Jon R. Lorsch
Jon R. Lorsch National Institutes of Health
Lauriane Kuhn
Lauriane Kuhn Centre national de la recherche scientifique, CNRS
Thomas Preiss
Thomas Preiss Australian National University
Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University
Ross D. Hannan
Ross D. Hannan Australian National University
Ola Larsson
Ola Larsson Science for Life Laboratory
Ivan Topisirovic
Ivan Topisirovic McGill University
Fan Zhang
Fan Zhang University of British Columbia
Petr Novák
Petr Novák ETH Zurich

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Molecular Biology in the USA opens doors to a variety of advanced online degrees and interesting career options. For students seeking to supplement their biosciences background with skills in mental health or psychology, there are accelerated programs designed for busy schedules. For example, you can consider a 1 year master's in psychology online to quickly gain expertise in human behavior and cognitive processes.

If your interest lies in supporting mental wellness, a fastest online counseling degree could help build a rewarding career as a counselor in clinical or educational settings.

For those curious about the intersection of biology, psychology, and law, you might ask: what can i do with a masters in forensic psychology? This specialty explores the role of psychology in the legal system, offering careers in criminal investigations, courtrooms, and beyond.

If working with children or adolescents fascinates you, an online child psychology degree could lead to specialized roles in schools, clinics, or research institutions. These pathways allow Molecular Biology graduates to apply their scientific background to diverse professions, expanding both knowledge and career possibilities.

Best Scientists Citing Leoš Shivaya Valášek

Trending Scientists