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D-Index & Metrics

Medicine

D-Index
77
Citations
17724
World Ranking
18566
National Ranking
9247

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Donald A. McClain is affiliated with Wake Forest University in the United States and has contributed extensively to research primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several specialized subfields, including Physiology, Molecular Biology, Hematology, Surgery, and Endocrinology, Diabetes and Metabolism.

The scientist's research topics cover a range of areas relevant to metabolic and physiological processes. These include:

  • Iron Metabolism and Disorders
  • Adipose Tissue and Metabolism
  • Metabolism, Diabetes, and Cancer
  • Receptor Mechanisms and Signaling
  • Diet and metabolism studies
  • Hemoglobinopathies and Related Disorders
  • Folate and B Vitamins Research

Frequent scholarly collaborators include Dalane W. Kitzman, Xiaoqiang Sun, Jing Cao, David Zhao, and Che Ping Cheng, each having coauthored multiple publications with McClain.

Published works appear in a variety of academic journals, with a notable presence in:

  • Circulation
  • Diabetes
  • Nature Reviews Endocrinology
  • The Journals of Gerontology Series A
  • Annual Review of Physiology

Examples of recent scholarly papers include:

  • "Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis" (2020) published in The Journals of Gerontology Series A
  • "Iron and the Pathophysiology of Diabetes" (2022) published in Annual Review of Physiology
  • "Consensus Statement on the definition and classification of metabolic hyperferritinaemia" (2023) published in Nature Reviews Endocrinology
  • "Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway" (2020) published in The American Journal of the Medical Sciences
  • "The Academic Learning Health System: A Framework for Integrating the Multiple Missions of Academic Medical Centers" (2023) published in Academic Medicine

Donald A. McClain has been recognized as a Member of the Association of American Physicians. The scientist remains active in their research domain without known affiliations to book publications.

Best Publications

  • Iron and diabetes risk.

    Judith A. Simcox;Donald A. McClain;Donald A. McClain

  • A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

    D A McClain;H Maegawa;J Lee;T J Dull

  • Functionally distinct insulin receptors generated by tissue-specific alternative splicing

    Luitgard Mosthaf;Kathleen Grako;Thomas J. Dull;Lisa Coussens

  • MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

    Christine M Kusminski;William L Holland;Kai Sun;Jiyoung Park

  • Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

    Darrell D. Belke;Sandrine Betuing;Martin J. Tuttle;Christophe Graveleau

  • Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

    Leon F. Hebert;Marc C. Daniels;Jianxin Zhou;Errol D. Crook

  • Hexosamines and Insulin Resistance

    Donald A McClain;Errol D Crook

  • A genetic mechanism for Tibetan high-altitude adaptation

    Felipe R. Lorenzo;Chad Huff;Chad Huff;Mikko Myllymäki;Benjamin Olenchock

  • Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

    Donald A. McClain;William A. Lubas;Robert C. Cooksey;Mark Hazel

  • Adipocyte iron regulates adiponectin and insulin sensitivity

    J. Scott Gabrielsen;Yan Gao;Judith A. Simcox;Jingyu Huang

  • The Role of mPer2 Clock Gene in Glucocorticoid and Feeding Rhythms

    Shutong Yang;Aiyi Liu;Adam Weidenhammer;Robert C. Cooksey

  • A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling *

    Adam R. Wende;Paul J. Schaeffer;Glendon J. Parker;Christoph Peter Gerhard Zechner

  • Oxidative stress, β-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis

    Robert C. Cooksey;Hani A. Jouihan;Richard S. Ajioka;Mark W. Hazel

  • Recipes for Creating Animal Models of Diabetic Cardiovascular Disease

    Willa Hsueh;E. Dale Abel;Jan L. Breslow;Nobuyo Maeda

  • Hexosamines as mediators of nutrient sensing and regulation in diabetes

    Donald A. McClain

  • Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces.

    Ravinder Nagpal;Shaohua Wang;Leah C. Solberg Woods;Osborne Seshie

  • Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.

    Donald A. McClain;Andrew J. Paterson;Mark D. Roos;Xiping Wei

  • Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

    J. David Symons;Shawna L. McMillin;Christian Riehle;Jason Tanner

  • Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes.

    José Manuel Fernández-Real;Donald McClain;Donald McClain;Melania Manco

  • Muscle damage and muscle remodeling: no pain, no gain?

    Kyle L. Flann;Paul C. Lastayo;Donald A. McClain;Mark Hazel

Frequent Co-Authors

Jerrold M. Olefsky
Jerrold M. Olefsky University of California, San Diego
Dalane W. Kitzman
Dalane W. Kitzman Wake Forest University
E. Dale Abel
E. Dale Abel University of California, Los Angeles
Gerald M. Edelman
Gerald M. Edelman Neurosciences Institute
James P. Kushner
James P. Kushner University of Utah
Victor R. Gordeuk
Victor R. Gordeuk University of Illinois at Chicago
Jack T. Rogers
Jack T. Rogers Harvard University
Robert R. Henry
Robert R. Henry University of California, San Diego
Hariom Yadav
Hariom Yadav University of South Florida
Jinchuan Xing
Jinchuan Xing Rutgers, The State University of New Jersey

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