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Biology and Biochemistry

D-Index
66
Citations
15910
World Ranking
8651
National Ranking
3881

Overview

Lance Wells is affiliated with the University of Georgia in the United States and focuses research efforts primarily in the field of Biochemistry, Genetics and Molecular Biology, with significant contributions to Molecular Biology, Immunology, Infectious Diseases, Organic Chemistry, and Spectroscopy. Their work spans several specialized topics, including Glycosylation and Glycoproteins Research, Carbohydrate Chemistry and Synthesis, Galectins and Cancer Biology, SARS-CoV-2 and COVID-19 Research, vaccines and immunoinformatics approaches, Biochemical and Molecular Research, and Plant and Fungal Interactions Research.

Recent scholarly output includes notable papers such as:

  • Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor (2020) published in Cell Host & Microbe
  • Four chromosome scale genomes and a pan-genome annotation to accelerate pecan tree breeding (2021) published in Nature Communications
  • An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase (2020) published in European Journal of Human Genetics
  • Regulating the Regulators: Mechanisms of Substrate Selection of the O-GlcNAc Cycling Enzymes OGT and OGA (2021) published in Glycobiology
  • Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes (2020) published in PLoS Genetics

Wells collaborates frequently with several co-authors, among whom are Peng Zhao, Jeremy L. Praissman, Kelley W. Moremen, Robert Bridger, and Michael Tiemeyer, reflecting ongoing partnerships in related research areas.

Their research findings appear regularly in specific scientific venues, including:

  • Journal of Biological Chemistry (10 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (9 publications)
  • Glycobiology (4 publications)
  • Molecular & Cellular Proteomics (4 publications)
  • Nature Communications (3 publications)

Throughout their career, Wells has concentrated on advancing knowledge related to glycosylation processes, viral receptor interactions, and molecular mechanisms underpinning genetic and immune system function. The interdisciplinary nature of these studies situates them at the interface of molecular biology and disease research, particularly in areas related to infectious diseases and biochemical pathway regulation.

Best Publications

  • RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

    Caryn R. Hale;Peng Zhao;Sara Olson;Michael O. Duff

  • Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

    Lance Wells;Keith Vosseller;Gerald W. Hart

  • Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins CLONING AND CHARACTERIZATION OF A NEUTRAL, CYTOSOLIC β-N-ACETYLGLUCOSAMINIDASE FROM HUMAN BRAIN

    Yuan Gao;Lance Wells;Frank I. Comer;Glendon J. Parker

  • Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

    Keith Vosseller;Lance Wells;M. Daniel Lane;Gerald Warren Hart

  • Mapping Sites of O-GlcNAc Modification Using Affinity Tags for Serine and Threonine Post-translational Modifications

    Lance Wells;Keith Vosseller;Robert N. Cole;Janet M. Cronshaw

  • Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.

    Peng Zhao;Jeremy L. Praissman;Oliver C. Grant;Yongfei Cai

  • O-Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding

    Takako Yoshida-Moriguchi;Liping Yu;Stephanie H. Stalnaker;Sarah Davis

  • Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine.

    Frank I. Comer;Keith Vosseller;Lance Wells;Mary Ann Accavitti

  • Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins FURTHER CHARACTERIZATION OF THE NUCLEOCYTOPLASMIC β-N-ACETYLGLUCOSAMINIDASE, O-GlcNAcase

    Lance Wells;Yuan Gao;James A. Mahoney;Keith Vosseller

  • Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo

    Kazuhiro Aoki;Mindy Perlman;Jae-Min Lim;Rebecca Cantu

  • A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance.

    L. Wells;K. Vosseller;Gerald Warren Hart

  • O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar.

    Lance Wells;Gerald Warren Hart

  • O-GlcNAc : a regulatory post-translational modification

    Lance Wells;Stephen A Whelan;Gerald W Hart

  • O-GlcNAc Transferase Is in a Functional Complex with Protein Phosphatase 1 Catalytic Subunits

    Lance Wells;Lisa K. Kreppel;Frank I. Comer;Brian E. Wadzinski

  • Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc

    Chin Fen Teo;Sampat Ingale;Margreet A Wolfert;Galal A Elsayed;Galal A Elsayed

  • Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii

    Matthew A. Humbard;Hugo V. Miranda;Jae-Min Lim;David J. Krause

  • Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol

    Keith Vosseller;Kirk C. Hansen;Robert J. Chalkley;Jonathan C. Trinidad

  • Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

    Tongqing Zhou;Nicole A. Doria-Rose;Cheng Cheng;Guillaume B.E. Stewart-Jones

  • Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment.

    Peng Zhao;Rosa Viner;Chin Fen Teo;Geert-Jan Boons

  • Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification.

    Keith Vosseller;Kaoru Sakabe;Lance Wells;Gerald Warren Hart

Frequent Co-Authors

Gerald W. Hart
Gerald W. Hart University of Georgia
Kelley W. Moremen
Kelley W. Moremen University of Georgia
Geert-Jan Boons
Geert-Jan Boons University of Georgia
Robert J. Woods
Robert J. Woods University of Georgia
Parastoo Azadi
Parastoo Azadi University of Georgia
Kevin P. Campbell
Kevin P. Campbell University of Iowa
William S. York
William S. York University of Georgia
Ron Orlando
Ron Orlando University of Georgia
James C. Paulson
James C. Paulson Scripps Research Institute
Stanley F. Nelson
Stanley F. Nelson University of California, Los Angeles

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