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David J. Vocadlo

David J. Vocadlo

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
27230
World Ranking
6514
National Ranking
234

Overview

David J. Vocadlo is affiliated with Simon Fraser University in Canada and focuses on research in biochemistry, genetics, and molecular biology, with significant contributions across medicine and chemistry. Their work spans several key subfields such as molecular biology, organic chemistry, physiology, cell biology, and immunology.

The scientist's research primarily addresses topics including carbohydrate chemistry and synthesis, glycosylation and glycoproteins research, lysosomal storage disorders research, cellular transport and secretion, galectins and cancer biology, biochemical and molecular research, and monoclonal and polyclonal antibodies research.

Frequent collaboration partners include Matthew C. Deen, G.J. Davies, Sha Zhu, Yanping Zhu, and Matthew G. Alteen.

Publications by David J. Vocadlo have appeared notably in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Angewandte Chemie International Edition, Angewandte Chemie, and the Journal of the American Chemical Society.

Recent papers demonstrate a focus on O-GlcNAcase inhibition and its biological effects as well as methodological advances in protein modification analysis. These include:

  • MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy, 2020, Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils, 2020, FEBS Journal
  • Monitoring and modulating O-GlcNAcylation: assays and inhibitors of O-GlcNAc processing enzymes, 2021, Current Opinion in Structural Biology
  • Precision Mapping of O-Linked N-Acetylglucosamine Sites in Proteins Using Ultraviolet Photodissociation Mass Spectrometry, 2020, Journal of the American Chemical Society
  • Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome, 2022, Journal of the American Chemical Society

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

    Scott A Yuzwa;Matthew S Macauley;Julia E Heinonen;Xiaoyang Shan

  • Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

    David J. Vocadlo;Gideon J. Davies;Gideon J. Davies;Roger Laine;Stephen G. Withers

  • A chemical approach for identifying O-GlcNAc-modified proteins in cells

    David J. Vocadlo;Howard C. Hang;Eun Ju Kim;John A. Hanover

  • Increasing O -GlcNAc slows neurodegeneration and stabilizes tau against aggregation

    Scott A Yuzwa;Xiaoyang Shan;Matthew S Macauley;Matthew S Macauley;Thomas Clark

  • Mechanistic insights into glycosidase chemistry.

    David J Vocadlo;Gideon J Davies

  • O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

    Matthew S. Macauley;Garrett E. Whitworth;Aleksandra W. Debowski;Danielle Chin

  • O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

    Christina M. Ferrer;Thomas P. Lynch;Valerie L. Sodi;John N. Falcone

  • Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.

    Brian L. Mark;David J. Vocadlo;Spencer Knapp;Barbara L. Triggs-Raine

  • NAG-thiazoline, An N-Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation

    Spencer Knapp;David Vocadlo;Zhinong Gao;Brian Kirk

  • Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

    Tracey M Gloster;Wesley F Zandberg;Julia E Heinonen;David L Shen

  • The emerging link between O-GlcNAc and Alzheimer disease.

    Yanping Zhu;Xiaoyang Shan;Scott A. Yuzwa;David J. Vocadlo

  • Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells

    Zhiyuan Ma;David J. Vocadlo;Keith Vosseller

  • O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

    Scott A. Yuzwa;David J. Vocadlo

  • Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)

    Donald A. R. Sinclair;Monika Syrzycka;Matthew S. Macauley;Tara Rastgardani

  • Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

    Rebecca J Dennis;Edward J Taylor;Matthew S Macauley;Keith A Stubbs

  • Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

    Tracey M Gloster;David J Vocadlo

  • HCF-1 is cleaved in the active site of O-GlcNAc transferase.

    Michael B. Lazarus;Jiaoyang Jiang;Vaibhav Kapuria;Tanja Bhuiyan

  • Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

    Garrett E. Whitworth;Matthew S. Macauley;Keith A. Stubbs;Rebecca J. Dennis

  • O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

    David J Vocadlo

Frequent Co-Authors

Gideon J. Davies
Gideon J. Davies University of York
Stephen G. Withers
Stephen G. Withers University of British Columbia
Alisdair B. Boraston
Alisdair B. Boraston University of Victoria
Harold G. Selnick
Harold G. Selnick MSD (United States)
Robert D. Burke
Robert D. Burke University of Victoria
Mirjam Czjzek
Mirjam Czjzek Sorbonne University
Michael N. G. James
Michael N. G. James University of Alberta
Antonio Oliver
Antonio Oliver Instituto de Salud Carlos III
Spencer Knapp
Spencer Knapp Rutgers, The State University of New Jersey
James C. Paton
James C. Paton University of Adelaide

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