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Chemistry

D-Index
42
Citations
6459
World Ranking
17531
National Ranking
4289

Overview

Spencer Knapp is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily spans the fields of Chemistry, Biochemistry, Genetics and Molecular Biology, and Materials Science. Within these areas, they have contributed notably to subfields such as Organic Chemistry, Materials Chemistry, Molecular Biology, Infectious Diseases, and Biochemistry.

The scientist's work engages with several main research topics including Synthesis and Catalytic Reactions, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Quinazolinone synthesis and applications, Synthesis and biological activity, HIV/AIDS drug development and treatment, as well as Biochemical and Molecular Research.

Recent publications by Spencer Knapp include:

  • Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials (2020, Bioorganic & Medicinal Chemistry)
  • Incorporation of an Isohexide Subunit Improves the Drug-like Properties of Bioactive Compounds (2023, ACS Medicinal Chemistry Letters)
  • Incorporation of an Isohexide Subunit into the Endochin-like Quinolone Scaffold (2024, Molecules)
  • Stereoelectronic Features of a Complex Ketene Dimerization Reaction (2021, Molecules)
  • A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly (2023, Journal of Inorganic Biochemistry)

The scientist frequently collaborates with a number of coauthors, including Thomas J. Emge, Robert D. Barrows, Paul R. Rablen, R. Kiplin Guy, and Jared T. Hammill. These collaborations reflect in the coauthored publications across various chemistry and biochemistry topics.

The prominent venues where Spencer Knapp has published their research include The Cambridge Structural Database, Molecules, Bioorganic & Medicinal Chemistry, ACS Medicinal Chemistry Letters, and the Journal of Inorganic Biochemistry. The largest number of publications appear in The Cambridge Structural Database, followed by contributions to Molecules and other specialized journals.

Best Publications

  • Synthesis of Complex Nucleoside Antibiotics

    Spencer. Knapp

  • Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.

    Brian L. Mark;David J. Vocadlo;Spencer Knapp;Barbara L. Triggs-Raine

  • NAG-thiazoline, An N-Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation

    Spencer Knapp;David Vocadlo;Zhinong Gao;Brian Kirk

  • Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    Brian L. Mark;Don J. Mahuran;Maia M. Cherney;Dalian Zhao

  • (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

    María Belén Jiménez-Díaz;Daniel Ebert;Yandira Salinas;Anupam Pradhan

  • A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin

    Chad Slawson;T. Lakshmanan;Spencer Knapp;Gerald Warren Hart

  • Synthesis and reactions of iodo lactams

    Spencer Knapp;Anthony T. Levorse

  • Synthesis of C-aryl glycosides

    Carlos Jaramillo;Spencer Knapp

  • Preparation, structure, and properties of pseudotetrahedral, D2d complexes of copper(II), nickel(II), cobalt(II), copper(I), and zinc(II) with the geometrically constraining bidentate ligand 2,2'-bis(2-imidazolyl)biphenyl. Examination of electron self-exchange for the Cu(I)/Cu(II) pair

    Spencer Knapp;Terence P. Keenan;Xiaohua Zhang;Ronald Fikar

  • Two Modes of Self-Coordinating Edge-over-Edge Zn(II) Porphyrin Dimerization: A Structural and Spectroscopic Comparison†

    Robert T. Stibrany;Jayasree Vasudevan;Spencer Knapp;Joseph A. Potenza

  • Amino alcohol and amino sugar synthesis by benzoylcarbamate cyclization

    Spencer Knapp;Paivi J. Kukkola;Shashi Sharma;T. G. Murali Dhar

  • Novel synthesis of enamines by iridium-catalyzed dehydrogenation of tertiary amines

    Xiawei Zhang;Amy Fried;Spencer Knapp;Alan S. Goldman

  • Synthesis of α-GalNAc Thioconjugates from an α-GalNAc Mercaptan

    Spencer Knapp;David S. Myers

  • Intramolecular amino delivery reactions for the synthesis of valienamine and analogues

    Spencer Knapp;Andrew B.J. Naughton;T.G. Murali Dhar

  • Electrophilic aromatic selenylation: new OPRT inhibitors.

    Mohannad Abdo;Yong Zhang;Vern L. Schramm;Spencer Knapp

  • Radical routes to indolizidines. Synthesis of (-)-slaframine

    Spencer Knapp;Frank S. Gibson

  • Biomimetic seleninates and selenonates.

    Mohannad Abdo;Spencer Knapp

  • New reactions of selenocarboxylates.

    Spencer Knapp;Etzer Darout

  • Synthesis of hypusine and other polyamines using dibenzyltriazones for amino protection

    Spencer Knapp;Jeffrey J. Hale;Margarita Bastos;Audrey Molina

  • A procedure for iodolactamization

    Spencer Knapp;Karen E. Rodriques;Anthony T. Levorse;Raphael M. Ornaf

  • Synthesis of capuramycin

    Spencer Knapp;Santosh R. Nandan

Frequent Co-Authors

Harvey J. Schugar
Harvey J. Schugar Rutgers, The State University of New Jersey
Thomas J. Emge
Thomas J. Emge Rutgers, The State University of New Jersey
Stephen G. Withers
Stephen G. Withers University of British Columbia
David J. Vocadlo
David J. Vocadlo Simon Fraser University
R. Kiplin Guy
R. Kiplin Guy University of Kentucky
Michael N. G. James
Michael N. G. James University of Alberta
Jerrold Meinwald
Jerrold Meinwald Cornell University
Susan A. Charman
Susan A. Charman Monash University
Dennis E. Kyle
Dennis E. Kyle University of Georgia
David A. Fidock
David A. Fidock Columbia University

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