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Don J. Mahuran

Don J. Mahuran

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
9259
World Ranking
17620
National Ranking
614

Overview

Don J. Mahuran is affiliated with the University of Toronto in Canada, engaging primarily in research at the intersection of medicine and molecular biology. Their work spans several subfields including physiology, epidemiology, molecular biology, organic chemistry, and neurology.

The research topics Mahuran has focused on include lysosomal storage disorders, glycosylation and glycoproteins, carbohydrate chemistry and synthesis, Parkinson's disease mechanisms and treatments, Alzheimer's disease research and treatments, cytomegalovirus and herpesvirus research, as well as mosquito-borne diseases and control.

Among the recent papers authored or co-authored by Mahuran are:

  • Ambroxol as a Treatment for Parkinson Disease Dementia, 2025, published in JAMA Neurology
  • Letter to the Editor, 2020, published in Molecular Therapy
  • Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease, 2020, published in UNC Libraries
  • In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside, 2020, published in UNC Libraries
  • Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo, 2020, published in UNC Libraries

Frequent publication venues for Mahuran's work include UNC Libraries, JAMA Neurology, and Molecular Therapy.

The scientist works collaboratively with several peers, with frequent coauthors including Steven J. Gray, Brian L. Mark, Subha Karumuthil-Melethil, and Patrick Thompson.

Best Publications

  • Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

    Stephen H. Pasternak;Richard D. Bagshaw;Marianne Guiral;Sunqu Zhang

  • Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease.

    Gustavo H.B. Maegawa;Michael B. Tropak;Justin D. Buttner;Brigitte A. Rigat

  • Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.

    Dapeng Zhou;Carlos Cantu;Yuval Sagiv;Nicolas Schrantz

  • Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients

    Michael B. Tropak;Stephen P. Reid;Marianne Guiral;Stephen G. Withers

  • Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    Brian L. Mark;Don J. Mahuran;Maia M. Cherney;Dalian Zhao

  • Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

    R G Korneluk;D J Mahuran;K Neote;M H Klavins

  • A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle

    Richard D. Bagshaw;Don J. Mahuran;John W. Callahan

  • Crystallographic Structure of Human β-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis

    M. Joanne Lemieux;Brian L. Mark;Maia M. Cherney;Stephen G. Withers

  • Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis

    Gustavo H.B. Maegawa;Michael Tropak;Justin Buttner;Tracy Stockley

  • The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of β‐glucosidase

    Richie Khanna;Elfrida R. Benjamin;Lee Pellegrino;Adriane Schilling

  • VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy

    Nivetha Ramachandran;Iulia Munteanu;Iulia Munteanu;Peixiang Wang;Alessandra Ruggieri

  • The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

    Stephen Howard Pasternak;John William Callahan;Don Joseph Mahuran

  • Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase.

    B F O'Dowd;F Quan;H F Willard;A M Lamhonwah

  • Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11.

    Benoît Renvoisé;Jaerak Chang;Rajat Singh;Sayuri Yonekawa

  • High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones

    Michael B. Tropak;Jan E. Blanchard;Stephen G. Withers;Eric D. Brown

  • Isofagomine induced stabilization of glucocerebrosidase.

    Gregory J. Kornhaber;Michael B. Tropak;Gustavo H. Maegawa;Steven J. Tuske

  • The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes.

    Richard D. Bagshaw;John W. Callahan;Don J. Mahuran

  • Molecular heterogeneity in the infantile and juvenile forms of Sandhoff disease (O-variant GM2 gangliosidosis).

    B F O'Dowd;M H Klavins;H F Willard;R Gravel

  • Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

    D J Mahuran;K Neote;M H Klavins;A Leung

  • Identification of the Gene Encoding the Enzyme Deficient in Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C)

    Xiaolian Fan;Huiwen Zhang;Sunqu Zhang;Richard D. Bagshaw

Frequent Co-Authors

Stephen G. Withers
Stephen G. Withers University of British Columbia
Michael N. G. James
Michael N. G. James University of Alberta
Hannu Kalimo
Hannu Kalimo University of Helsinki
Cameron Ackerley
Cameron Ackerley University of Toronto
Ichizo Nishino
Ichizo Nishino Tokyo Medical University
Carlo Minetti
Carlo Minetti University of Genoa
Berge A. Minassian
Berge A. Minassian The University of Texas Southwestern Medical Center
Bjarne Udd
Bjarne Udd University of Helsinki
Brian F. O'Dowd
Brian F. O'Dowd Centre for Addiction and Mental Health
Nicolas Lévy
Nicolas Lévy Aix-Marseille University

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