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Don J. Mahuran

Don J. Mahuran

University of Toronto
Canada

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
9259
World Ranking
17620
National Ranking
614

Don J. Mahuran publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Don J. Mahuran sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 193 publications — 47th percentile

47% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Don J. Mahuran D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Don J. Mahuran sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 50 D-Index — 11th percentile

11% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Don J. Mahuran is affiliated with the University of Toronto in Canada, engaging primarily in research at the intersection of medicine and molecular biology. Their work spans several subfields including physiology, epidemiology, molecular biology, organic chemistry, and neurology.

The research topics Mahuran has focused on include lysosomal storage disorders, glycosylation and glycoproteins, carbohydrate chemistry and synthesis, Parkinson's disease mechanisms and treatments, Alzheimer's disease research and treatments, cytomegalovirus and herpesvirus research, as well as mosquito-borne diseases and control.

Among the recent papers authored or co-authored by Mahuran are:

  • Ambroxol as a Treatment for Parkinson Disease Dementia, 2025, published in JAMA Neurology
  • Letter to the Editor, 2020, published in Molecular Therapy
  • Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease, 2020, published in UNC Libraries
  • In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside, 2020, published in UNC Libraries
  • Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo, 2020, published in UNC Libraries

Frequent publication venues for Mahuran's work include UNC Libraries, JAMA Neurology, and Molecular Therapy.

The scientist works collaboratively with several peers, with frequent coauthors including Steven J. Gray, Brian L. Mark, Subha Karumuthil-Melethil, and Patrick Thompson.

Best Publications

  • Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

    Stephen H. Pasternak;Richard D. Bagshaw;Marianne Guiral;Sunqu Zhang

  • Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease.

    Gustavo H.B. Maegawa;Michael B. Tropak;Justin D. Buttner;Brigitte A. Rigat

  • Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.

    Dapeng Zhou;Carlos Cantu;Yuval Sagiv;Nicolas Schrantz

  • Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients

    Michael B. Tropak;Stephen P. Reid;Marianne Guiral;Stephen G. Withers

  • Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    Brian L. Mark;Don J. Mahuran;Maia M. Cherney;Dalian Zhao

  • Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

    R G Korneluk;D J Mahuran;K Neote;M H Klavins

  • A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle

    Richard D. Bagshaw;Don J. Mahuran;John W. Callahan

  • Crystallographic Structure of Human β-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis

    M. Joanne Lemieux;Brian L. Mark;Maia M. Cherney;Stephen G. Withers

  • Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis

    Gustavo H.B. Maegawa;Michael Tropak;Justin Buttner;Tracy Stockley

  • The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of β‐glucosidase

    Richie Khanna;Elfrida R. Benjamin;Lee Pellegrino;Adriane Schilling

  • VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy

    Nivetha Ramachandran;Iulia Munteanu;Iulia Munteanu;Peixiang Wang;Alessandra Ruggieri

  • The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

    Stephen Howard Pasternak;John William Callahan;Don Joseph Mahuran

  • Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase.

    B F O'Dowd;F Quan;H F Willard;A M Lamhonwah

  • Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11.

    Benoît Renvoisé;Jaerak Chang;Rajat Singh;Sayuri Yonekawa

  • High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones

    Michael B. Tropak;Jan E. Blanchard;Stephen G. Withers;Eric D. Brown

  • Isofagomine induced stabilization of glucocerebrosidase.

    Gregory J. Kornhaber;Michael B. Tropak;Gustavo H. Maegawa;Steven J. Tuske

  • The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes.

    Richard D. Bagshaw;John W. Callahan;Don J. Mahuran

  • Molecular heterogeneity in the infantile and juvenile forms of Sandhoff disease (O-variant GM2 gangliosidosis).

    B F O'Dowd;M H Klavins;H F Willard;R Gravel

  • Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

    D J Mahuran;K Neote;M H Klavins;A Leung

  • Identification of the Gene Encoding the Enzyme Deficient in Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C)

    Xiaolian Fan;Huiwen Zhang;Sunqu Zhang;Richard D. Bagshaw

Frequent Co-Authors

Stephen G. Withers
Stephen G. Withers University of British Columbia
Michael N. G. James
Michael N. G. James University of Alberta
Hannu Kalimo
Hannu Kalimo University of Helsinki
Cameron Ackerley
Cameron Ackerley University of Toronto
Ichizo Nishino
Ichizo Nishino Tokyo Medical University
Carlo Minetti
Carlo Minetti University of Genoa
Berge A. Minassian
Berge A. Minassian The University of Texas Southwestern Medical Center
Bjarne Udd
Bjarne Udd University of Helsinki
Brian F. O'Dowd
Brian F. O'Dowd Centre for Addiction and Mental Health
Nicolas Lévy
Nicolas Lévy Aix-Marseille University

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Best Scientists Citing Don J. Mahuran

Konrad Sandhoff

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Stephen G. Withers

Stephen G. Withers

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Publications: 38

David J. Vocadlo

David J. Vocadlo

Simon Fraser University

Publications: 29

Gurdyal S. Besra

Gurdyal S. Besra

University of Birmingham

Publications: 27

Ellen Sidransky

Ellen Sidransky

National Institutes of Health

Publications: 24

Terry D. Butters

Terry D. Butters

University of Oxford

Publications: 24

Luc Teyton

Luc Teyton

Scripps Research Institute

Publications: 20

José M. García Fernández

José M. García Fernández

University of Seville

Publications: 20

Carmen Ortiz Mellet

Carmen Ortiz Mellet

University of Seville

Publications: 20

Johannes M. F. G. Aerts

Johannes M. F. G. Aerts

Leiden University

Publications: 20

Frances M. Platt

Frances M. Platt

University of Oxford

Publications: 20

Louis Hermo

Louis Hermo

McGill University

Publications: 19

Mitchell Kronenberg

Mitchell Kronenberg

University of California, San Diego

Publications: 18

Gennaro De Libero

Gennaro De Libero

University Hospital of Basel

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University of Toyama

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